CRCGN012_HEPG2_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

157 genes differentially expressed following the CRCGN012_HEPG2_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
ABHD4 abhydrolase domain containing 4 7.68141
TXNRD1 thioredoxin reductase 1 7.52012
HMOX1 heme oxygenase 1 5.19898
UGDH UDP-glucose 6-dehydrogenase 5.17139
KLHL21 kelch-like family member 21 5.16418
LCN2 lipocalin 2 5.07961
H2BC12 H2B clustered histone 12 4.83315
FOSL1 FOS-like antigen 1 4.76262
SQSTM1 sequestosome 1 4.72782
PRR15L proline rich 15-like 4.52211
RPP38 ribonuclease P/MRP 38kDa subunit 4.21991
NOSIP nitric oxide synthase interacting protein 4.03936
TIAM1 T-cell lymphoma invasion and metastasis 1 3.78019
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.76976
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.71158
RPL39L ribosomal protein L39-like 3.5343
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.52452
TEX10 testis expressed 10 3.51386
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.50415
NOTCH1 notch 1 3.4862
ATP11B ATPase, class VI, type 11B 3.47165
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.45864
SMIM40 small integral membrane protein 40 3.43144
CIAO3 cytosolic iron-sulfur assembly component 3 3.39377
KEAP1 kelch-like ECH-associated protein 1 3.39239
ADGRE5 adhesion G protein-coupled receptor E5 3.34672
ZW10 zw10 kinetochore protein 3.31915
CCL2 chemokine (C-C motif) ligand 2 3.22475
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.19104
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.06378
ANXA1 annexin A1 3.0483
TATDN2 TatD DNase domain containing 2 3.03421
GCLM glutamate-cysteine ligase, modifier subunit 3.03112
CDPF1 cysteine-rich, DPF motif domain containing 1 3.00066
TERF2IP telomeric repeat binding factor 2, interacting protein 2.95519
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.94524
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.94371
TIMP2 TIMP metallopeptidase inhibitor 2 2.92577
SOD1 superoxide dismutase 1, soluble 2.92362
MCOLN1 mucolipin 1 2.91056
ALAS1 5'-aminolevulinate synthase 1 2.90537
CSK c-src tyrosine kinase 2.8871
TMEM50A transmembrane protein 50A 2.87386
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.85359
BAG3 BCL2-associated athanogene 3 2.84668
CHMP6 charged multivesicular body protein 6 2.83817
HSPA1A heat shock 70kDa protein 1A 2.80396
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.78244
TUBB6 tubulin, beta 6 class V 2.7757
GADD45A growth arrest and DNA-damage-inducible, alpha 2.7449
TBPL1 TBP-like 1 2.73082
GSTZ1 glutathione S-transferase zeta 1 2.72842
TMEM109 transmembrane protein 109 2.70749
MVP major vault protein 2.68583
BACE2 beta-site APP-cleaving enzyme 2 2.66657
GABARAPL1 GABA(A) receptor-associated protein like 1 2.63906
TBC1D31 TBC1 domain family, member 31 2.6308
CTSL cathepsin L 2.60242
SFTPB surfactant protein B 2.5336
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.40391
BLCAP bladder cancer associated protein 2.40086
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.32573
ZNF586 zinc finger protein 586 2.31819
TWF2 twinfilin actin binding protein 2 2.28798
PEX11A peroxisomal biogenesis factor 11 alpha 2.24413
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.21623
LRP10 low density lipoprotein receptor-related protein 10 2.20873
SLC38A6 solute carrier family 38, member 6 2.2046
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.19193
BIRC2 baculoviral IAP repeat containing 2 2.18074
TXNL4B thioredoxin-like 4B 2.16561
MYLK myosin light chain kinase 2.15654
FRS2 fibroblast growth factor receptor substrate 2 2.15621
NAP1L2 nucleosome assembly protein 1-like 2 2.15094
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.15038
BANP BTG3 associated nuclear protein 2.14815
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.13403
RAD51C RAD51 paralog C 2.13396
GPATCH8 G patch domain containing 8 2.13368
H2BC21 H2B clustered histone 21 2.11684
CBR1 carbonyl reductase 1 2.11288
DDHD2 DDHD domain containing 2 2.10848
RRAGA Ras-related GTP binding A 2.0818
RNASE7 ribonuclease, RNase A family, 7 2.06855
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.06467
FECH ferrochelatase 2.0602
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.05963
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.0593
AATF apoptosis antagonizing transcription factor 2.03548
RIPK4 receptor-interacting serine-threonine kinase 4 2.02031
PIR pirin (iron-binding nuclear protein) 2.01576
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.00431
RXYLT1 ribitol xylosyltransferase 1 2.00191

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.6781
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.76957
LDHD lactate dehydrogenase D -6.71169
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.58101
NT5DC2 5'-nucleotidase domain containing 2 -5.26656
PCCB propionyl CoA carboxylase, beta polypeptide -4.72901
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.41756
FGFR4 fibroblast growth factor receptor 4 -4.4122
TSPAN4 tetraspanin 4 -4.37461
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.25719
TRIB3 tribbles pseudokinase 3 -4.11383
COG2 component of oligomeric golgi complex 2 -4.05163
MRPS16 mitochondrial ribosomal protein S16 -4.02241
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.92592
PGM1 phosphoglucomutase 1 -3.92239
TCEAL4 transcription elongation factor A (SII)-like 4 -3.86296
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -3.86064
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.85691
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.74727
INTS3 integrator complex subunit 3 -3.38559
OXA1L oxidase (cytochrome c) assembly 1-like -3.29086
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.23651
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.18517
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.06945
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.04973
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.94965
GET1 guided entry of tail-anchored proteins factor 1 -2.94267
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.91475
CCNB2 cyclin B2 -2.86172
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.70589
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.6943
TOP2A topoisomerase (DNA) II alpha 170kDa -2.6784
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.53577
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.5275
NNT nicotinamide nucleotide transhydrogenase -2.47321
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.44662
HMGA2 high mobility group AT-hook 2 -2.41464
HYOU1 hypoxia up-regulated 1 -2.39664
USP6NL USP6 N-terminal like -2.35377
MRPL16 mitochondrial ribosomal protein L16 -2.33383
BCKDK branched chain ketoacid dehydrogenase kinase -2.32976
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.32973
VAV3 vav 3 guanine nucleotide exchange factor -2.31472
ACADVL acyl-CoA dehydrogenase, very long chain -2.28547
ICAM1 intercellular adhesion molecule 1 -2.25341
ILK integrin-linked kinase -2.25189
RBM15B RNA binding motif protein 15B -2.21888
NISCH nischarin -2.20607
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.12072
DUSP6 dual specificity phosphatase 6 -2.12066
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.10092
SSBP2 single-stranded DNA binding protein 2 -2.08186
PHACTR1 phosphatase and actin regulator 1 -2.07277
TCEAL1 transcription elongation factor A (SII)-like 1 -2.06079
RFTN1 raftlin, lipid raft linker 1 -2.06036
ANKRD10 ankyrin repeat domain 10 -2.05984
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.05536
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.04097
CD58 CD58 molecule -2.0407
ZNF274 zinc finger protein 274 -2.03547
STK25 serine/threonine kinase 25 -2.02191
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.02165
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.01397