CRCGN012_HEPG2_24H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN012_HEPG2_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 8.68639
LCN2 lipocalin 2 7.69276
TXNRD1 thioredoxin reductase 1 7.31922
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.87821
ADGRE5 adhesion G protein-coupled receptor E5 6.72935
NOTCH1 notch 1 6.05498
UGDH UDP-glucose 6-dehydrogenase 5.6824
HMOX1 heme oxygenase 1 4.72718
FOSL1 FOS-like antigen 1 4.53004
CHN1 chimerin 1 4.49287
H2BC12 H2B clustered histone 12 4.42125
SQSTM1 sequestosome 1 4.12476
KEAP1 kelch-like ECH-associated protein 1 3.97139
CDPF1 cysteine-rich, DPF motif domain containing 1 3.57229
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.52931
STK10 serine/threonine kinase 10 3.46554
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.39895
CSK c-src tyrosine kinase 3.36807
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.16703
BAG3 BCL2-associated athanogene 3 3.13787
UBQLN2 ubiquilin 2 3.10071
KIFBP kinesin family binding protein 2.95868
IDE insulin-degrading enzyme 2.95313
CBR3 carbonyl reductase 3 2.88664
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.83807
PEX11A peroxisomal biogenesis factor 11 alpha 2.7984
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.76474
STIMATE STIM activating enhancer 2.7579
MYLK myosin light chain kinase 2.6882
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.66069
CEP57 centrosomal protein 57kDa 2.61032
FPGS folylpolyglutamate synthase 2.5901
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.57143
ALAS1 5'-aminolevulinate synthase 1 2.46642
TMEM50A transmembrane protein 50A 2.3843
CTSL cathepsin L 2.37829
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.36905
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.31192
ZNF589 zinc finger protein 589 2.30922
JMJD6 jumonji domain containing 6 2.2283
ASCC3 activating signal cointegrator 1 complex subunit 3 2.22507
MCOLN1 mucolipin 1 2.17712
RPP38 ribonuclease P/MRP 38kDa subunit 2.11779
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.11303
BAG2 BCL2-associated athanogene 2 2.04887
RRAGA Ras-related GTP binding A 2.03216
BANP BTG3 associated nuclear protein 2.02246
BLCAP bladder cancer associated protein 2.01255
TMEM109 transmembrane protein 109 2.00087

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.19472
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.11344
FGFR4 fibroblast growth factor receptor 4 -5.85601
PCNA proliferating cell nuclear antigen -5.50587
PGM1 phosphoglucomutase 1 -5.07604
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.5752
HMG20B high mobility group 20B -3.80544
RPS5 ribosomal protein S5 -3.64077
PCCB propionyl CoA carboxylase, beta polypeptide -3.52469
MRPS2 mitochondrial ribosomal protein S2 -3.43166
GET1 guided entry of tail-anchored proteins factor 1 -3.39621
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.16153
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.02066
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.01555
FBXL12 F-box and leucine-rich repeat protein 12 -3.00879
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.87869
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.83277
STAMBP STAM binding protein -2.67827
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.67767
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.65247
MAPK13 mitogen-activated protein kinase 13 -2.64933
NIT1 nitrilase 1 -2.562
INTS3 integrator complex subunit 3 -2.53246
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.50682
OXA1L oxidase (cytochrome c) assembly 1-like -2.50603
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.49715
DCAF13 DDB1 and CUL4 associated factor 13 -2.48963
UBE3C ubiquitin protein ligase E3C -2.47249
ELAC1 elaC ribonuclease Z 1 -2.45992
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -2.40748
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.39074
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.37619
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.35869
TM9SF3 transmembrane 9 superfamily member 3 -2.3208
ZDHHC6 zinc finger, DHHC-type containing 6 -2.31539
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.31302
HMGA2 high mobility group AT-hook 2 -2.30781
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.28999
FOS FBJ murine osteosarcoma viral oncogene homolog -2.28851
GIPC2 GIPC PDZ domain containing family, member 2 -2.27537
C2CD5 C2 calcium-dependent domain containing 5 -2.24724
NISCH nischarin -2.24717
ICAM1 intercellular adhesion molecule 1 -2.24129
GOLT1B golgi transport 1B -2.23821
ZNHIT1 zinc finger, HIT-type containing 1 -2.23307
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.22702
CRELD2 cysteine-rich with EGF-like domains 2 -2.22654
USP6NL USP6 N-terminal like -2.14513
DUSP6 dual specificity phosphatase 6 -2.11367
TOP2A topoisomerase (DNA) II alpha 170kDa -2.09956
USP27X ubiquitin specific peptidase 27, X-linked -2.09055
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -2.08425
SPATA31A3 SPATA31 subfamily A, member 3 -2.06902
EMC10 ER membrane protein complex subunit 10 -2.05016
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.01314
NNT nicotinamide nucleotide transhydrogenase -2.01103
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.00418
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.00207
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.00079