CRCGN012_HEPG2_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description endosulfan 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

133 genes differentially expressed following the CRCGN012_HEPG2_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 6.40282
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.78976
ABHD6 abhydrolase domain containing 6 4.78893
STK10 serine/threonine kinase 10 4.63013
CARMIL1 capping protein regulator and myosin 1 linker 1 4.54497
ANO1 anoctamin 1, calcium activated chloride channel 4.50066
PRR15L proline rich 15-like 4.29407
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.8936
PPARG peroxisome proliferator-activated receptor gamma 3.64061
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.53103
EPN2 epsin 2 3.43653
GSTZ1 glutathione S-transferase zeta 1 3.28114
MPC2 mitochondrial pyruvate carrier 2 3.25513
MOK MOK protein kinase 3.23881
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.03692
SOCS2 suppressor of cytokine signaling 2 2.96031
NOSIP nitric oxide synthase interacting protein 2.95635
VGLL4 vestigial-like family member 4 2.83108
CCDC85B coiled-coil domain containing 85B 2.77859
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.72369
PCNA proliferating cell nuclear antigen 2.63596
MAP7 microtubule-associated protein 7 2.54052
GPER1 G protein-coupled estrogen receptor 1 2.53222
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.49637
TEX10 testis expressed 10 2.37577
ARID4A AT rich interactive domain 4A (RBP1-like) 2.36726
TBXA2R thromboxane A2 receptor 2.36073
PLSCR3 phospholipid scramblase 3 2.35201
HYI hydroxypyruvate isomerase (putative) 2.32
EMID1 EMI domain containing 1 2.30479
CDPF1 cysteine-rich, DPF motif domain containing 1 2.29293
AXIN1 axin 1 2.27717
HEBP1 heme binding protein 1 2.25786
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.24334
SCAND1 SCAN domain containing 1 2.22612
EDC4 enhancer of mRNA decapping 4 2.19083
METRN meteorin, glial cell differentiation regulator 2.18072
SPA17 sperm autoantigenic protein 17 2.1677
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.16316
FHOD1 formin homology 2 domain containing 1 2.1587
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.13159
PRSS3 protease, serine, 3 2.12618
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.12068
EDN1 endothelin 1 2.12042
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.11036
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.10724
SPEF1 sperm flagellar 1 2.07615
CLBA1 clathrin binding box of aftiphilin containing 1 2.06065
ADRA2C adrenoceptor alpha 2C 2.02776
CYB561 cytochrome b561 2.0248
JADE2 jade family PHD finger 2 2.02421
TPPP tubulin polymerization promoting protein 2.02335
INF2 inverted formin, FH2 and WH2 domain containing 2.01921
TMEM176A transmembrane protein 176A 2.01389
STOML1 stomatin (EPB72)-like 1 2.0075
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.00074

decreased expression

Symbol Name Standardized Value
ZDHHC6 zinc finger, DHHC-type containing 6 -9.40748
KDM3A lysine (K)-specific demethylase 3A -5.25111
TRIB3 tribbles pseudokinase 3 -5.12743
TM9SF3 transmembrane 9 superfamily member 3 -5.08983
PEG10 paternally expressed 10 -4.89092
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.88393
NIT1 nitrilase 1 -4.79238
CCDC86 coiled-coil domain containing 86 -4.61872
FGFR4 fibroblast growth factor receptor 4 -4.61682
NT5DC2 5'-nucleotidase domain containing 2 -4.47546
GTPBP8 GTP-binding protein 8 (putative) -4.40934
ADI1 acireductone dioxygenase 1 -3.87726
GDF15 growth differentiation factor 15 -3.78293
GNAS GNAS complex locus -3.71452
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.64023
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.61936
GOLT1B golgi transport 1B -3.30844
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.10524
RAB4A RAB4A, member RAS oncogene family -3.04394
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.02986
RFC2 replication factor C (activator 1) 2, 40kDa -2.81039
BLMH bleomycin hydrolase -2.80448
PRKCD protein kinase C, delta -2.76335
CLIC4 chloride intracellular channel 4 -2.74575
KIF2C kinesin family member 2C -2.74358
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.68619
BEND5 BEN domain containing 5 -2.68573
BIRC2 baculoviral IAP repeat containing 2 -2.66136
MYL9 myosin, light chain 9, regulatory -2.64855
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.60289
EXOC5 exocyst complex component 5 -2.55567
GPC3 glypican 3 -2.54902
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.52677
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.49467
MAPK13 mitogen-activated protein kinase 13 -2.4901
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.45955
TENT4A terminal nucleotidyltransferase 4A -2.45626
ZNF263 zinc finger protein 263 -2.44971
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.44953
TMEM39B transmembrane protein 39B -2.43689
KCTD20 potassium channel tetramerization domain containing 20 -2.37986
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.35094
ANKRD44 ankyrin repeat domain 44 -2.29149
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -2.28195
ZNF322 zinc finger protein 322 -2.26747
STIP1 stress-induced phosphoprotein 1 -2.26713
ZW10 zw10 kinetochore protein -2.26379
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.23116
NFYA nuclear transcription factor Y, alpha -2.22723
LOC102724652 alpha-crystallin A chain -2.20369
HIPK3 homeodomain interacting protein kinase 3 -2.20365
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.19368
HLA-C major histocompatibility complex, class I, C -2.18786
OSMR oncostatin M receptor -2.18148
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.17586
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.17471
CREB1 cAMP responsive element binding protein 1 -2.16792
CPVL carboxypeptidase, vitellogenic-like -2.14571
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.14356
TMEM255A transmembrane protein 255A -2.14351
HLA-A major histocompatibility complex, class I, A -2.12777
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.11994
PCP4 Purkinje cell protein 4 -2.11669
ZNF557 zinc finger protein 557 -2.10793
VLDLR very low density lipoprotein receptor -2.09228
ZNF7 zinc finger protein 7 -2.09005
SYT17 synaptotagmin XVII -2.08896
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.08242
SIX1 SIX homeobox 1 -2.08068
SLC35A5 solute carrier family 35, member A5 -2.0761
CUL4B cullin 4B -2.07525
ABHD17B abhydrolase domain containing 17B -2.06248
ZNF200 zinc finger protein 200 -2.05895
MEF2A myocyte enhancer factor 2A -2.0278
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.01392
SCYL2 SCY1-like 2 (S. cerevisiae) -2.00915
XPO7 exportin 7 -2.00581