CRCGN012_HEPG2_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2-methylanthraquinone 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN012_HEPG2_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 5.60915
TXNRD1 thioredoxin reductase 1 5.24819
UGDH UDP-glucose 6-dehydrogenase 5.02902
RAP1GAP RAP1 GTPase activating protein 4.92382
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.65081
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.03343
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.8788
CDC45 cell division cycle 45 3.83344
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.7368
ABHD4 abhydrolase domain containing 4 3.58081
CYCS cytochrome c, somatic 3.55432
CIAO3 cytosolic iron-sulfur assembly component 3 3.48146
MVP major vault protein 3.38238
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.30626
GSTZ1 glutathione S-transferase zeta 1 3.23007
CDK6 cyclin-dependent kinase 6 3.1
ZFP36 ZFP36 ring finger protein 3.02704
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.96525
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.90823
STK10 serine/threonine kinase 10 2.86701
BACE2 beta-site APP-cleaving enzyme 2 2.81373
AARS1 alanyl-tRNA synthetase 1 2.77019
SPDEF SAM pointed domain containing ETS transcription factor 2.76599
CSK c-src tyrosine kinase 2.73325
HMOX1 heme oxygenase 1 2.70052
STAP2 signal transducing adaptor family member 2 2.69507
DUSP6 dual specificity phosphatase 6 2.67475
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.52597
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.51692
ZMIZ1 zinc finger, MIZ-type containing 1 2.51123
PYGL phosphorylase, glycogen, liver 2.49619
ABHD6 abhydrolase domain containing 6 2.49187
EVL Enah/Vasp-like 2.48701
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.48164
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.46448
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.45653
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.44811
ETFB electron-transfer-flavoprotein, beta polypeptide 2.37832
LOC124907782 dual specificity protein phosphatase 22 2.34933
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.29958
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.28487
CBR1 carbonyl reductase 1 2.20894
FGL1 fibrinogen-like 1 2.18589
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.1799
DDIT4 DNA-damage-inducible transcript 4 2.16447
TWF2 twinfilin actin binding protein 2 2.13116
KEAP1 kelch-like ECH-associated protein 1 2.09112
TFF3 trefoil factor 3 (intestinal) 2.07603
PRKCD protein kinase C, delta 2.072
GRB14 growth factor receptor-bound protein 14 2.06848
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.04432
CCDC92 coiled-coil domain containing 92 2.03873
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.01373

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.33414
LDHD lactate dehydrogenase D -6.32666
CCNB2 cyclin B2 -6.16355
GNAS GNAS complex locus -5.49419
ALDOC aldolase C, fructose-bisphosphate -4.99857
MAPK13 mitogen-activated protein kinase 13 -4.94728
CDC20 cell division cycle 20 -4.73632
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.3835
RAI14 retinoic acid induced 14 -3.42194
PDLIM1 PDZ and LIM domain 1 -3.00909
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.69596
PGAM4 phosphoglycerate mutase family member 4 -2.69024
TUBB6 tubulin, beta 6 class V -2.66645
PEG10 paternally expressed 10 -2.6574
BIRC2 baculoviral IAP repeat containing 2 -2.63076
MAP7 microtubule-associated protein 7 -2.60445
CRELD2 cysteine-rich with EGF-like domains 2 -2.57591
SPAG4 sperm associated antigen 4 -2.50297
TOMM34 translocase of outer mitochondrial membrane 34 -2.45529
CCNB1 cyclin B1 -2.41836
PPY pancreatic polypeptide -2.38469
CDK1 cyclin-dependent kinase 1 -2.37965
NUCB2 nucleobindin 2 -2.36557
PCDH8 protocadherin 8 -2.26352
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.25745
LOC124900388 uncharacterized LOC124900388 -2.19712
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.1438
EIF5 eukaryotic translation initiation factor 5 -2.11694
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.09134
JMJD6 jumonji domain containing 6 -2.08673
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.07253
PNMA8A PNMA family member 8A -2.06084
PRPF4 pre-mRNA processing factor 4 -2.02123