| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-amino-2-methylanthraquinone 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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112 genes differentially expressed following the CRCGN012_HEPG2_24H:H02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.36877 |
| HOXA10 | homeobox A10 | 5.15456 |
| TXNRD1 | thioredoxin reductase 1 | 4.71103 |
| VAT1 | vesicle amine transport 1 | 4.7049 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 4.44187 |
| RAP1GAP | RAP1 GTPase activating protein | 3.99042 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.92508 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.794 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 3.58078 |
| MAMLD1 | mastermind-like domain containing 1 | 3.5305 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.4436 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.14126 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.13186 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 3.10803 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.02452 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.99593 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 2.98688 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.94832 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.93615 |
| HOXA11 | homeobox A11 | 2.92061 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.86033 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 2.85833 |
| RBM15B | RNA binding motif protein 15B | 2.8436 |
| CSK | c-src tyrosine kinase | 2.79607 |
| E2F2 | E2F transcription factor 2 | 2.72545 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 2.72156 |
| PLS1 | plastin 1 | 2.64268 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 2.62021 |
| MVP | major vault protein | 2.61185 |
| CDC45 | cell division cycle 45 | 2.56016 |
| STAP2 | signal transducing adaptor family member 2 | 2.55119 |
| HMOX1 | heme oxygenase 1 | 2.5193 |
| EPN2 | epsin 2 | 2.51392 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.50132 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 2.45484 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.41336 |
| SFTPB | surfactant protein B | 2.39593 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.36973 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.32285 |
| PYGL | phosphorylase, glycogen, liver | 2.32097 |
| PRKCD | protein kinase C, delta | 2.29916 |
| PKN1 | protein kinase N1 | 2.22886 |
| ABHD4 | abhydrolase domain containing 4 | 2.2284 |
| TRAPPC12 | trafficking protein particle complex 12 | 2.2235 |
| DUSP6 | dual specificity phosphatase 6 | 2.21781 |
| ATG9A | autophagy related 9A | 2.21659 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.21164 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.1909 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 2.18402 |
| GPATCH8 | G patch domain containing 8 | 2.13865 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.13856 |
| RAB5C | RAB5C, member RAS oncogene family | 2.0744 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.06838 |
| CCDC92 | coiled-coil domain containing 92 | 2.05734 |
| XPOT | exportin, tRNA | 2.04897 |
| CLTCL1 | clathrin, heavy chain-like 1 | 2.0409 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -10.0 |
| SLC35F2 | solute carrier family 35, member F2 | -7.9838 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -4.99532 |
| ALDOC | aldolase C, fructose-bisphosphate | -4.77168 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.0679 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.93709 |
| EGF | epidermal growth factor | -3.8998 |
| CD320 | CD320 molecule | -3.8659 |
| PCNA | proliferating cell nuclear antigen | -3.4974 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -3.32435 |
| ZNF586 | zinc finger protein 586 | -3.31988 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.28436 |
| ENOPH1 | enolase-phosphatase 1 | -3.25831 |
| LDHD | lactate dehydrogenase D | -3.21748 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | -2.92133 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.82473 |
| RPS5 | ribosomal protein S5 | -2.82015 |
| ADI1 | acireductone dioxygenase 1 | -2.78556 |
| TUBB6 | tubulin, beta 6 class V | -2.75045 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.71974 |
| FSTL1 | follistatin-like 1 | -2.68459 |
| VDAC1 | voltage-dependent anion channel 1 | -2.66924 |
| MAP7 | microtubule-associated protein 7 | -2.59267 |
| NGRN | neugrin, neurite outgrowth associated | -2.51392 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.50375 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.46661 |
| JPT2 | Jupiter microtubule associated homolog 2 | -2.45332 |
| S100A4 | S100 calcium binding protein A4 | -2.43064 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.41932 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.34248 |
| ZNF302 | zinc finger protein 302 | -2.31685 |
| NUCB2 | nucleobindin 2 | -2.28154 |
| MSMO1 | methylsterol monooxygenase 1 | -2.2731 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.25641 |
| BIRC2 | baculoviral IAP repeat containing 2 | -2.23556 |
| CLCC1 | chloride channel CLIC-like 1 | -2.23329 |
| ZNF263 | zinc finger protein 263 | -2.22575 |
| SQOR | sulfide quinone oxidoreductase | -2.19832 |
| CASP8AP2 | caspase 8 associated protein 2 | -2.19245 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.18454 |
| NHLRC2 | NHL repeat containing 2 | -2.18265 |
| COG2 | component of oligomeric golgi complex 2 | -2.16616 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.15123 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.1197 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -2.11101 |
| MRPL49 | mitochondrial ribosomal protein L49 | -2.10501 |
| EIF4E | eukaryotic translation initiation factor 4E | -2.10353 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -2.08218 |
| SCAND1 | SCAN domain containing 1 | -2.07732 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.05519 |
| PPY | pancreatic polypeptide | -2.05502 |
| SNN | stannin | -2.05135 |
| SUCO | SUN domain containing ossification factor | -2.03675 |
| FLNC | filamin C, gamma | -2.03143 |
| CA2 | carbonic anhydrase II | -2.01771 |
| ZNF91 | zinc finger protein 91 | -2.01694 |
