CRCGN012_HEPG2_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2-methylanthraquinone 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

156 genes differentially expressed following the CRCGN012_HEPG2_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 7.30577
CSK c-src tyrosine kinase 6.7154
CHMP6 charged multivesicular body protein 6 5.88334
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.84508
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.40091
LOC122526780 uncharacterized LOC122526780 4.17591
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.94947
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.87675
UBQLN2 ubiquilin 2 3.62863
NFIL3 nuclear factor, interleukin 3 regulated 3.58732
SFTPB surfactant protein B 3.58012
PPARG peroxisome proliferator-activated receptor gamma 3.48076
CARMIL1 capping protein regulator and myosin 1 linker 1 3.4441
MAMLD1 mastermind-like domain containing 1 3.41613
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.40042
VAT1 vesicle amine transport 1 3.38402
HOXA10 homeobox A10 3.24359
GSTZ1 glutathione S-transferase zeta 1 3.21688
TXNRD1 thioredoxin reductase 1 3.10535
MYLK myosin light chain kinase 3.06037
MVP major vault protein 3.036
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.91444
LCN2 lipocalin 2 2.90553
ADRB2 adrenoceptor beta 2, surface 2.90271
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.88946
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.88546
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.85108
DYNLT3 dynein, light chain, Tctex-type 3 2.81553
PEAK1 pseudopodium-enriched atypical kinase 1 2.74922
CXCL2 chemokine (C-X-C motif) ligand 2 2.72896
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.71649
HOXC8 homeobox C8 2.71004
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.70862
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.7072
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.67868
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.64519
UGDH UDP-glucose 6-dehydrogenase 2.64478
EPHA3 EPH receptor A3 2.60226
NHLH1 nescient helix loop helix 1 2.58432
MCC mutated in colorectal cancers 2.55082
TET3 tet methylcytosine dioxygenase 3 2.53991
WDTC1 WD and tetratricopeptide repeats 1 2.53739
IFNA13 interferon, alpha 13 2.50871
ABI2 abl-interactor 2 2.50456
SOD3 superoxide dismutase 3, extracellular 2.50132
SSBP3 single stranded DNA binding protein 3 2.49537
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.47262
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.44572
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.43621
DNAAF3 dynein, axonemal, assembly factor 3 2.43316
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A 2.43211
KLK14 kallikrein-related peptidase 14 2.43078
PADI1 peptidyl arginine deiminase, type I 2.39843
JADE2 jade family PHD finger 2 2.39714
NEUROD2 neuronal differentiation 2 2.3942
MEF2C myocyte enhancer factor 2C 2.38651
LRP6 low density lipoprotein receptor-related protein 6 2.37909
ODF1 outer dense fiber of sperm tails 1 2.36378
LUZP4 leucine zipper protein 4 2.35523
USP6 ubiquitin specific peptidase 6 2.34547
HPSE2 heparanase 2 (inactive) 2.33353
KLK12 kallikrein-related peptidase 12 2.3254
MAST2 microtubule associated serine/threonine kinase 2 2.31745
ZMYM3 zinc finger, MYM-type 3 2.30768
GRK1 G protein-coupled receptor kinase 1 2.29892
CHN1 chimerin 1 2.29775
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.29147
ZIC4 Zic family member 4 2.27768
CETN1 centrin, EF-hand protein, 1 2.2588
GLRA2 glycine receptor, alpha 2 2.25535
NEUROD6 neuronal differentiation 6 2.25317
EDA2R ectodysplasin A2 receptor 2.25289
GPR52 G protein-coupled receptor 52 2.23647
GLI1 GLI family zinc finger 1 2.23309
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.22576
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.21402
TMEM35A transmembrane protein 35A 2.19859
TMC7 transmembrane channel-like 7 2.19263
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.1888
GDF5 growth differentiation factor 5 2.17904
CCDC7 coiled-coil domain containing 7 2.17761
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.17491
AMHR2 anti-Mullerian hormone receptor, type II 2.16616
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.16455
FGF17 fibroblast growth factor 17 2.16295
KLF15 Kruppel-like factor 15 2.15645
ZIC3 Zic family member 3 2.15047
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.14897
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2.14407
UPK3A uroplakin 3A 2.12944
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.1257
BARX2 BARX homeobox 2 2.12168
SIRPB1 signal-regulatory protein beta 1 2.11434
CER1 cerberus 1, DAN family BMP antagonist 2.11406
ALX3 ALX homeobox 3 2.11001
CLBA1 clathrin binding box of aftiphilin containing 1 2.1032
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.10276
PCDHGB5 protocadherin gamma subfamily B, 5 2.10037
BICD1 bicaudal D homolog 1 (Drosophila) 2.09851
DCLK1 doublecortin-like kinase 1 2.09591
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.09323
NPDC1 neural proliferation, differentiation and control, 1 2.08667
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.08307
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough 2.0816
GJB4 gap junction protein, beta 4, 30.3kDa 2.06847
PRB2 proline-rich protein BstNI subfamily 2 2.06741
INO80D INO80 complex subunit D 2.06739
ADPRH ADP-ribosylarginine hydrolase 2.06445
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.06384
CCL2 chemokine (C-C motif) ligand 2 2.06325
IL36A interleukin 36, alpha 2.06195
ZNF507 zinc finger protein 507 2.05845
NXPH3 neurexophilin 3 2.05509
QSER1 glutamine and serine rich 1 2.05196
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.04776
NOD1 nucleotide-binding oligomerization domain containing 1 2.04623
SHBG sex hormone-binding globulin 2.0444
CNTLN centlein, centrosomal protein 2.03714
RGS17 regulator of G-protein signaling 17 2.029
GDF3 growth differentiation factor 3 2.02801
PGLYRP4 peptidoglycan recognition protein 4 2.02497
SH3BP1 SH3-domain binding protein 1 2.02444
GRPR gastrin-releasing peptide receptor 2.02164
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.02018
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.01964
GPER1 G protein-coupled estrogen receptor 1 2.01443
GFER growth factor, augmenter of liver regeneration 2.0115
GJD2 gap junction protein, delta 2, 36kDa 2.00692
EYA3 EYA transcriptional coactivator and phosphatase 3 2.00368
NEUROG1 neurogenin 1 2.00292
RNF122 ring finger protein 122 2.00269
WDR4 WD repeat domain 4 2.00252

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -6.38244
LDHD lactate dehydrogenase D -6.1356
MAPK13 mitogen-activated protein kinase 13 -5.30545
TUBB6 tubulin, beta 6 class V -4.62397
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.50174
MAP7 microtubule-associated protein 7 -4.4247
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.28741
NT5DC2 5'-nucleotidase domain containing 2 -3.76228
KDM3A lysine (K)-specific demethylase 3A -3.66706
TRIB3 tribbles pseudokinase 3 -3.44045
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.42094
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.20488
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.75116
RFC2 replication factor C (activator 1) 2, 40kDa -2.71331
GNAS GNAS complex locus -2.66925
FBXL12 F-box and leucine-rich repeat protein 12 -2.65403
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.54994
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.48795
RAI14 retinoic acid induced 14 -2.40782
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.31672
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.18201
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.07148
MSMO1 methylsterol monooxygenase 1 -2.02178
ICAM3 intercellular adhesion molecule 3 -2.00493