CRCGN012_HEPG2_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2-methylanthraquinone 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN012_HEPG2_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 8.34645
NR1H2 nuclear receptor subfamily 1, group H, member 2 8.22745
STIMATE STIM activating enhancer 8.02259
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.91611
PPARG peroxisome proliferator-activated receptor gamma 5.78729
ATP11B ATPase, class VI, type 11B 5.27856
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.72083
PNKP polynucleotide kinase 3'-phosphatase 4.67865
INTS3 integrator complex subunit 3 4.60289
E2F2 E2F transcription factor 2 4.54908
AMDHD2 amidohydrolase domain containing 2 4.51896
CSK c-src tyrosine kinase 4.25025
UBQLN2 ubiquilin 2 4.23712
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.11982
EPHB2 EPH receptor B2 4.09035
SNAP25 synaptosomal-associated protein, 25kDa 4.03304
EPHA3 EPH receptor A3 3.92736
TIAM1 T-cell lymphoma invasion and metastasis 1 3.89001
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.87933
VAV3 vav 3 guanine nucleotide exchange factor 3.79914
PEX11A peroxisomal biogenesis factor 11 alpha 3.75686
GSTZ1 glutathione S-transferase zeta 1 3.5948
HOXA10 homeobox A10 3.55734
CHMP6 charged multivesicular body protein 6 3.41279
GPATCH8 G patch domain containing 8 3.37705
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.34135
GATA3 GATA binding protein 3 3.3327
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.12544
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.06486
ADGRE5 adhesion G protein-coupled receptor E5 3.05043
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.82128
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.81757
CIAO3 cytosolic iron-sulfur assembly component 3 2.80806
KDM5A lysine (K)-specific demethylase 5A 2.69856
CCNF cyclin F 2.65932
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.52576
RPL39L ribosomal protein L39-like 2.40934
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.39871
BBS7 Bardet-Biedl syndrome 7 2.37032
CILK1 ciliogenesis associated kinase 1 2.36891
IL5 interleukin 5 2.36354
H2BC12 H2B clustered histone 12 2.36022
WASF3 WAS protein family, member 3 2.34612
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.31279
PTOV1 prostate tumor overexpressed 1 2.25033
MAST2 microtubule associated serine/threonine kinase 2 2.23409
ERCC1 excision repair cross-complementation group 1 2.23231
OLAH oleoyl-ACP hydrolase 2.20338
PLCL1 phospholipase C-like 1 2.18442
VSTM4 V-set and transmembrane domain containing 4 2.16981
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.15953
S100A6 S100 calcium binding protein A6 2.15741
HOXC10 homeobox C10 2.15066
MAGEC1 melanoma antigen family C1 2.14612
MAMLD1 mastermind-like domain containing 1 2.13437
RRAS related RAS viral (r-ras) oncogene homolog 2.10239
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.06614
MCPH1 microcephalin 1 2.06296
GARRE1 granule associated Rac and RHOG effector 1 2.05176
LIPG lipase, endothelial 2.0493
FOXD2 forkhead box D2 2.02396
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 2.01657
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.01419
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.00196
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.00103

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.12558
LDHD lactate dehydrogenase D -5.36589
RFC2 replication factor C (activator 1) 2, 40kDa -4.65237
ZMIZ1 zinc finger, MIZ-type containing 1 -4.53629
DERA deoxyribose-phosphate aldolase (putative) -3.86825
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.82315
YME1L1 YME1-like 1 ATPase -3.62036
ZNF586 zinc finger protein 586 -3.44646
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.19519
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.06852
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.0131
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.91133
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.84633
GDF15 growth differentiation factor 15 -2.79168
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.61238
TCTN1 tectonic family member 1 -2.4896
C2CD5 C2 calcium-dependent domain containing 5 -2.411
CTNND1 catenin (cadherin-associated protein), delta 1 -2.36545
DUSP8 dual specificity phosphatase 8 -2.30793
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.26306
TMEM97 transmembrane protein 97 -2.10859
APEH acylaminoacyl-peptide hydrolase -2.09638
FBXW4 F-box and WD repeat domain containing 4 -2.09147
BAG1 BCL2-associated athanogene -2.06923
IRAK1 interleukin-1 receptor-associated kinase 1 -2.02452