CRCGN012_HEPG2_24H:H07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN012_HEPG2_24H:H07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 8.92917
TXNRD1 thioredoxin reductase 1 6.88688
CSK c-src tyrosine kinase 6.64627
UGDH UDP-glucose 6-dehydrogenase 6.29142
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.58961
HMOX1 heme oxygenase 1 5.53506
MAMLD1 mastermind-like domain containing 1 4.45211
CTSL cathepsin L 4.37451
SQSTM1 sequestosome 1 3.68259
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.59436
CHMP6 charged multivesicular body protein 6 3.45041
GPER1 G protein-coupled estrogen receptor 1 3.36429
MEST mesoderm specific transcript 3.3552
KEAP1 kelch-like ECH-associated protein 1 3.22411
CBR1 carbonyl reductase 1 3.14976
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.10201
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.08688
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.01598
FCHO1 FCH domain only 1 3.01081
GSTZ1 glutathione S-transferase zeta 1 3.00822
TRIB3 tribbles pseudokinase 3 2.88577
SNAP25 synaptosomal-associated protein, 25kDa 2.82607
ZFP36 ZFP36 ring finger protein 2.73215
TALDO1 transaldolase 1 2.64036
GCLM glutamate-cysteine ligase, modifier subunit 2.6261
RRAGA Ras-related GTP binding A 2.60843
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.55745
GSR glutathione reductase 2.55434
GPC1 glypican 1 2.51347
DEAF1 DEAF1 transcription factor 2.35289
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.33505
CEP57 centrosomal protein 57kDa 2.32452
NUCB2 nucleobindin 2 2.21123
LRP10 low density lipoprotein receptor-related protein 10 2.20746
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.20393
BHMT2 betaine--homocysteine S-methyltransferase 2 2.10422
LCN2 lipocalin 2 2.09434
DIPK1A divergent protein kinase domain 1A 2.09314
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.09143
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.09094
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.07492
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.05675
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.0436
ABHD6 abhydrolase domain containing 6 2.00858
CCL2 chemokine (C-C motif) ligand 2 2.00596

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.08726
NGRN neugrin, neurite outgrowth associated -6.12944
CASP3 caspase 3, apoptosis-related cysteine peptidase -5.30041
CDC20 cell division cycle 20 -4.29935
ZNF586 zinc finger protein 586 -3.84661
CCNB2 cyclin B2 -3.78496
ZMIZ1 zinc finger, MIZ-type containing 1 -3.56119
ARID5B AT rich interactive domain 5B (MRF1-like) -3.46628
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.39264
PSRC1 proline/serine-rich coiled-coil 1 -3.14553
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.12805
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.06927
OXA1L oxidase (cytochrome c) assembly 1-like -3.01932
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.94927
ILK integrin-linked kinase -2.92888
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.82074
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.78163
CD58 CD58 molecule -2.68459
FASTKD5 FAST kinase domains 5 -2.42228
EGF epidermal growth factor -2.42184
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.11536
ZW10 zw10 kinetochore protein -2.10225
MST1R macrophage stimulating 1 receptor -2.09523
HAT1 histone acetyltransferase 1 -2.07379
CDC42 cell division cycle 42 -2.06976
TLCD3A TLC domain containing 3A -2.00977
CCL14 chemokine (C-C motif) ligand 14 -2.00206