CRCGN012_HEPG2_24H:H08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN012_HEPG2_24H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 9.3754
PPARG peroxisome proliferator-activated receptor gamma 8.8776
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.673
TXNRD1 thioredoxin reductase 1 5.4486
GSTZ1 glutathione S-transferase zeta 1 5.33725
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.1206
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.09925
SIRT3 sirtuin 3 4.94788
UGDH UDP-glucose 6-dehydrogenase 4.9125
LCN2 lipocalin 2 4.8546
AXIN1 axin 1 4.6198
DYNLT3 dynein, light chain, Tctex-type 3 4.50885
ABHD4 abhydrolase domain containing 4 4.4584
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.3959
HOXA10 homeobox A10 4.01615
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.9122
PEX11A peroxisomal biogenesis factor 11 alpha 3.90867
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.62145
CYCS cytochrome c, somatic 3.43175
MAP7 microtubule-associated protein 7 3.31688
HMOX1 heme oxygenase 1 3.2302
CBR1 carbonyl reductase 1 3.1979
NUCB2 nucleobindin 2 3.1758
CCNH cyclin H 3.1554
CTSL cathepsin L 3.13075
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.10252
KEAP1 kelch-like ECH-associated protein 1 3.02775
LPAR2 lysophosphatidic acid receptor 2 2.9499
SQSTM1 sequestosome 1 2.88453
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.847
NLRX1 NLR family member X1 2.5155
RIC8A RIC8 guanine nucleotide exchange factor A 2.4208
UROS uroporphyrinogen III synthase 2.3705
VGLL4 vestigial-like family member 4 2.23452
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.2066
SPINK5 serine peptidase inhibitor, Kazal type 5 2.19745
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.1852
CRCT1 cysteine-rich C-terminal 1 2.1254
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.05473
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.0512
TBP TATA box binding protein 2.0391
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.0303

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.73955
OXA1L oxidase (cytochrome c) assembly 1-like -5.1058
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.03395
FGFR4 fibroblast growth factor receptor 4 -5.01517
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
TRIB3 tribbles pseudokinase 3 -4.92975
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.6985
PECR peroxisomal trans-2-enoyl-CoA reductase -4.6398
CCNB2 cyclin B2 -4.525
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.7691
GNAS GNAS complex locus -3.54841
TM9SF3 transmembrane 9 superfamily member 3 -3.29425
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.20185
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.96079
CCNB1 cyclin B1 -2.80395
SMC4 structural maintenance of chromosomes 4 -2.56793
ABT1 activator of basal transcription 1 -2.48695
WASHC4 WASH complex subunit 4 -2.31395
NLRP4 NLR family, pyrin domain containing 4 -2.2812
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.27447
ZMIZ1 zinc finger, MIZ-type containing 1 -2.26805
IGFBP7 insulin-like growth factor binding protein 7 -2.2309
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.21325
MATN4 matrilin 4 -2.18065
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.0983
LRRC49 leucine rich repeat containing 49 -2.06305
TUBB6 tubulin, beta 6 class V -2.03805