CRCGN012_HEPG2_24H:H09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN012_HEPG2_24H:H09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.76615
ATP11B ATPase, class VI, type 11B 4.11977
ADRB2 adrenoceptor beta 2, surface 3.73281
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.72711
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.65668
PPARG peroxisome proliferator-activated receptor gamma 3.52444
MELK maternal embryonic leucine zipper kinase 3.39484
SNAP25 synaptosomal-associated protein, 25kDa 3.38356
GSTZ1 glutathione S-transferase zeta 1 3.33892
LCN2 lipocalin 2 3.28253
BZW2 basic leucine zipper and W2 domains 2 3.28224
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.18138
UGDH UDP-glucose 6-dehydrogenase 2.90773
CHMP6 charged multivesicular body protein 6 2.8767
CIAO3 cytosolic iron-sulfur assembly component 3 2.80276
PLS1 plastin 1 2.80201
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.78564
HSPA1A heat shock 70kDa protein 1A 2.57668
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.48344
HOXA10 homeobox A10 2.44737
SMIM40 small integral membrane protein 40 2.43522
UBQLN2 ubiquilin 2 2.43229
TXNRD1 thioredoxin reductase 1 2.42862
PMM2 phosphomannomutase 2 2.30836
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.27984
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.22351
JADE2 jade family PHD finger 2 2.15081
ABHD4 abhydrolase domain containing 4 2.01371

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.99541
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.64512
PCCB propionyl CoA carboxylase, beta polypeptide -4.03174
MAP7 microtubule-associated protein 7 -3.80128
MRPS16 mitochondrial ribosomal protein S16 -3.79681
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.3945
GTPBP8 GTP-binding protein 8 (putative) -3.24651
ANKRD10 ankyrin repeat domain 10 -3.21258
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.13073
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.10521
ZDHHC6 zinc finger, DHHC-type containing 6 -3.02038
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.71121
CCNB1 cyclin B1 -2.52988
WASHC4 WASH complex subunit 4 -2.42729
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.2498
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.24469
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.14176
YME1L1 YME1-like 1 ATPase -2.08512
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.00158