CRCGN012_HEPG2_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.14112
BACE2 beta-site APP-cleaving enzyme 2 4.10941
MAMLD1 mastermind-like domain containing 1 3.66685
STK10 serine/threonine kinase 10 3.64784
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.48922
CSK c-src tyrosine kinase 3.4338
NOSIP nitric oxide synthase interacting protein 3.31645
PMM2 phosphomannomutase 2 3.20337
NOTCH1 notch 1 3.1908
AMDHD2 amidohydrolase domain containing 2 3.17661
ATP11B ATPase, class VI, type 11B 3.1578
DIPK1A divergent protein kinase domain 1A 2.89968
H2BC12 H2B clustered histone 12 2.86527
EPHA3 EPH receptor A3 2.79798
SIRT3 sirtuin 3 2.61994
STIMATE STIM activating enhancer 2.55144
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.47682
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.35292
NMU neuromedin U 2.25893
GPER1 G protein-coupled estrogen receptor 1 2.18004
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.17609
ZNF813 zinc finger protein 813 2.16105
ZNF589 zinc finger protein 589 2.08134
TPD52L2 tumor protein D52-like 2 2.04924
COQ3 coenzyme Q3 methyltransferase 2.04775
PPARG peroxisome proliferator-activated receptor gamma 2.03195

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -4.80683
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.49156
SLC35F2 solute carrier family 35, member F2 -4.32753
LDHD lactate dehydrogenase D -4.16227
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.98685
LOC124907782 dual specificity protein phosphatase 22 -3.93351
PECR peroxisomal trans-2-enoyl-CoA reductase -3.87027
CDC20 cell division cycle 20 -3.82072
DSG2 desmoglein 2 -3.62258
CCNB1 cyclin B1 -3.60552
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.60172
C2CD5 C2 calcium-dependent domain containing 5 -3.60104
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.48409
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.48365
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.36202
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.1837
PRPF4 pre-mRNA processing factor 4 -3.1599
TOMM34 translocase of outer mitochondrial membrane 34 -3.10426
RFC2 replication factor C (activator 1) 2, 40kDa -2.89098
THAP11 THAP domain containing 11 -2.69617
HMG20B high mobility group 20B -2.67889
CCDC86 coiled-coil domain containing 86 -2.59692
TERF2IP telomeric repeat binding factor 2, interacting protein -2.55709
CCNB2 cyclin B2 -2.36868
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.35826
FBXL12 F-box and leucine-rich repeat protein 12 -2.34451
DUSP6 dual specificity phosphatase 6 -2.3273
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.31295
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.31011
OXA1L oxidase (cytochrome c) assembly 1-like -2.29298
PLK1 polo-like kinase 1 -2.15583
CHMP4B charged multivesicular body protein 4B -2.09281
CD58 CD58 molecule -2.04575