CRCGN012_HEPG2_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN012_HEPG2_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.5581
LCN2 lipocalin 2 4.08041
NMU neuromedin U 3.30262
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.2368
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.09449
LPAR2 lysophosphatidic acid receptor 2 3.02366
SMIM40 small integral membrane protein 40 2.863
ADGRE5 adhesion G protein-coupled receptor E5 2.80492
C2CD2 C2 calcium-dependent domain containing 2 2.65819
GSTZ1 glutathione S-transferase zeta 1 2.61919
LOC122526780 uncharacterized LOC122526780 2.51262
PRKCH protein kinase C, eta 2.383
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.38115
SATB1 SATB homeobox 1 2.35136
TIAM1 T-cell lymphoma invasion and metastasis 1 2.26456
BLMH bleomycin hydrolase 2.0806
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.06829
PCNA proliferating cell nuclear antigen 2.05914
PLSCR1 phospholipid scramblase 1 2.03003

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.25627
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.74413
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.7018
NT5DC2 5'-nucleotidase domain containing 2 -3.59036
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.46445
SNX11 sorting nexin 11 -3.25465
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.63912
ZNF586 zinc finger protein 586 -2.59942
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.47383
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.32565
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.31785
EIF5 eukaryotic translation initiation factor 5 -2.21486
MAP7 microtubule-associated protein 7 -2.12122
NVL nuclear VCP-like -2.06076
GPATCH1 G patch domain containing 1 -2.05981
ZNF146 zinc finger protein 146 -2.04901
ZNF222 zinc finger protein 222 -2.01982
PDCD5 programmed cell death 5 -2.01285