CRCGN012_HEPG2_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

73 genes differentially expressed following the CRCGN012_HEPG2_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 6.09717
TXNRD1 thioredoxin reductase 1 3.96142
UGDH UDP-glucose 6-dehydrogenase 3.92414
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.59184
MINDY1 MINDY lysine 48 deubiquitinase 1 3.4692
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.32301
ANO1 anoctamin 1, calcium activated chloride channel 3.31551
PPARG peroxisome proliferator-activated receptor gamma 3.23394
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.20974
SNAP25 synaptosomal-associated protein, 25kDa 3.20104
PRKCQ protein kinase C, theta 3.17708
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.12981
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.12607
CDPF1 cysteine-rich, DPF motif domain containing 1 3.08069
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.06442
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.01298
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.01016
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.94684
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.88551
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.69677
E2F2 E2F transcription factor 2 2.68376
ZFP36 ZFP36 ring finger protein 2.66726
VAT1 vesicle amine transport 1 2.62458
LCN2 lipocalin 2 2.6113
ABHD4 abhydrolase domain containing 4 2.58007
SQSTM1 sequestosome 1 2.49419
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.49181
RXYLT1 ribitol xylosyltransferase 1 2.42095
CHGB chromogranin B 2.39052
RAB21 RAB21, member RAS oncogene family 2.37136
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.32738
TEX10 testis expressed 10 2.28111
CCP110 centriolar coiled coil protein 110kDa 2.24997
DDIT4 DNA-damage-inducible transcript 4 2.24626
INPP1 inositol polyphosphate-1-phosphatase 2.21405
STXBP1 syntaxin binding protein 1 2.12747
PHGDH phosphoglycerate dehydrogenase 2.08365
PARD6A par-6 family cell polarity regulator alpha 2.05622
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.05169
YARS1 tyrosyl-tRNA synthetase 1 2.03393
RHCG Rh family, C glycoprotein 2.02714
IDE insulin-degrading enzyme 2.01622

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -10.0
HSPB1 heat shock 27kDa protein 1 -4.18254
CCDC86 coiled-coil domain containing 86 -3.8119
CCNB1 cyclin B1 -3.6291
TLCD3A TLC domain containing 3A -3.49012
ZNF586 zinc finger protein 586 -3.37897
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.37797
PECR peroxisomal trans-2-enoyl-CoA reductase -3.32301
SMNDC1 survival motor neuron domain containing 1 -3.25111
FAIM Fas apoptotic inhibitory molecule -3.24746
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.20794
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.03089
CHMP4B charged multivesicular body protein 4B -3.01259
OXA1L oxidase (cytochrome c) assembly 1-like -2.84091
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.67301
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.59613
DSG2 desmoglein 2 -2.42149
CCNB2 cyclin B2 -2.40195
FBXL12 F-box and leucine-rich repeat protein 12 -2.37216
PSRC1 proline/serine-rich coiled-coil 1 -2.35676
ZNF263 zinc finger protein 263 -2.34965
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.29679
SNX11 sorting nexin 11 -2.23998
RFC2 replication factor C (activator 1) 2, 40kDa -2.19497
BFAR bifunctional apoptosis regulator -2.19414
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.16684
S100A4 S100 calcium binding protein A4 -2.15542
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.14939
MRPL49 mitochondrial ribosomal protein L49 -2.09452
MPHOSPH8 M-phase phosphoprotein 8 -2.05675
HMOX2 heme oxygenase 2 -2.03415