CRCGN012_HEPG2_24H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bisphenol-a 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN012_HEPG2_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 6.89151
TIAM1 T-cell lymphoma invasion and metastasis 1 6.31603
CHN1 chimerin 1 6.0132
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.51179
ADRB2 adrenoceptor beta 2, surface 5.26124
CBR3 carbonyl reductase 3 5.20657
CHMP6 charged multivesicular body protein 6 5.13469
STIMATE STIM activating enhancer 4.9956
ATP11B ATPase, class VI, type 11B 4.93136
ADGRE5 adhesion G protein-coupled receptor E5 4.78643
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.20245
PRR15L proline rich 15-like 4.17777
STK10 serine/threonine kinase 10 4.0902
MYLK myosin light chain kinase 4.061
UBQLN2 ubiquilin 2 4.04776
KLHL9 kelch-like family member 9 3.4526
RXYLT1 ribitol xylosyltransferase 1 3.01854
GPER1 G protein-coupled estrogen receptor 1 3.00041
SFTPB surfactant protein B 2.86488
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.85146
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.57422
FMOD fibromodulin 2.43626
CYCS cytochrome c, somatic 2.37182
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.21702
HOOK2 hook microtubule-tethering protein 2 2.20988
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.17308
CHEK2 checkpoint kinase 2 2.13559
SLC35H1 solute carrier family 35 member H1 2.11187
ORC6 origin recognition complex, subunit 6 2.09374
FRZB frizzled-related protein 2.04501

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.39528
LDHD lactate dehydrogenase D -4.89518
PCCB propionyl CoA carboxylase, beta polypeptide -4.76122
CCDC86 coiled-coil domain containing 86 -4.44432
MRPS2 mitochondrial ribosomal protein S2 -4.34703
CHMP4B charged multivesicular body protein 4B -4.27059
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.11659
CDC20 cell division cycle 20 -3.92539
FGFR4 fibroblast growth factor receptor 4 -3.71439
BLCAP bladder cancer associated protein -3.66353
MAPK13 mitogen-activated protein kinase 13 -3.5145
FAIM Fas apoptotic inhibitory molecule -3.40511
SNX11 sorting nexin 11 -2.74706
PECR peroxisomal trans-2-enoyl-CoA reductase -2.6178
MAP7 microtubule-associated protein 7 -2.51268
RBM42 RNA binding motif protein 42 -2.3612
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.35629
LGMN legumain -2.30011
ARID5B AT rich interactive domain 5B (MRF1-like) -2.29156
SESN1 sestrin 1 -2.22874
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.14738
NLK nemo-like kinase -2.1326
RIMBP2 RIMS binding protein 2 -2.08323