| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | penicillin-v-potassium 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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115 genes differentially expressed following the CRCGN012_HEPG2_24H:I05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 10.0 |
| UBQLN2 | ubiquilin 2 | 10.0 |
| PRR15L | proline rich 15-like | 9.1848 |
| CHN1 | chimerin 1 | 6.99925 |
| E2F2 | E2F transcription factor 2 | 5.87165 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.33725 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.27625 |
| TAC4 | tachykinin 4 (hemokinin) | 5.1995 |
| GPER1 | G protein-coupled estrogen receptor 1 | 5.18415 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.1323 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.8834 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.73715 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.57895 |
| PRKCQ | protein kinase C, theta | 4.26 |
| ATP11B | ATPase, class VI, type 11B | 4.24815 |
| IDE | insulin-degrading enzyme | 4.18302 |
| CBR3 | carbonyl reductase 3 | 4.1605 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.9246 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.66755 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.6285 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.2976 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.0382 |
| ABHD6 | abhydrolase domain containing 6 | 3.00925 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 2.9641 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.92105 |
| LOC122526780 | uncharacterized LOC122526780 | 2.7413 |
| NMU | neuromedin U | 2.7005 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.6702 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 2.59385 |
| MRTFB | myocardin related transcription factor B | 2.55285 |
| ACP6 | acid phosphatase 6, lysophosphatidic | 2.5239 |
| CYCS | cytochrome c, somatic | 2.5238 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 2.50122 |
| STX18 | syntaxin 18 | 2.38455 |
| MKRN2 | makorin ring finger protein 2 | 2.37075 |
| PTK2 | protein tyrosine kinase 2 | 2.36618 |
| ENO2 | enolase 2 (gamma, neuronal) | 2.36355 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.3511 |
| CDK6 | cyclin-dependent kinase 6 | 2.3298 |
| TBX2 | T-box 2 | 2.31768 |
| BORA | bora, aurora kinase A activator | 2.3113 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 2.29745 |
| PRR16 | proline rich 16 | 2.2672 |
| TPO | thyroid peroxidase | 2.25945 |
| SELENOF | selenoprotein F | 2.25635 |
| UNC119B | unc-119 homolog B (C. elegans) | 2.2428 |
| FKBP5 | FK506 binding protein 5 | 2.21565 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 2.2038 |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 2.19825 |
| CDC45 | cell division cycle 45 | 2.1566 |
| RBP4 | retinol binding protein 4, plasma | 2.14295 |
| PI4KA | phosphatidylinositol 4-kinase, catalytic, alpha | 2.14225 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 2.13305 |
| PGR | progesterone receptor | 2.1302 |
| ATAD2 | ATPase family, AAA domain containing 2 | 2.12915 |
| RPL36A | ribosomal protein L36a | 2.1162 |
| DUOX2 | dual oxidase 2 | 2.114 |
| TMEM39B | transmembrane protein 39B | 2.10345 |
| ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 | 2.08825 |
| RPS19 | ribosomal protein S19 | 2.08523 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 2.06562 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 2.04595 |
| CAAP1 | caspase activity and apoptosis inhibitor 1 | 2.03345 |
| EPHB6 | EPH receptor B6 | 2.028 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -10.0 |
| CCNB2 | cyclin B2 | -8.00055 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -6.64057 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -5.27175 |
| VAT1 | vesicle amine transport 1 | -5.2118 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.08015 |
| ZNF586 | zinc finger protein 586 | -5.07375 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -5.04225 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.0 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.76465 |
| THAP11 | THAP domain containing 11 | -4.7027 |
| CAB39 | calcium binding protein 39 | -4.60925 |
| CDC20 | cell division cycle 20 | -3.6851 |
| SNX11 | sorting nexin 11 | -3.48415 |
| CPNE3 | copine III | -3.37072 |
| PCNA | proliferating cell nuclear antigen | -3.2969 |
| TES | testin LIM domain protein | -3.2636 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -3.03763 |
| EGF | epidermal growth factor | -2.8856 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.8772 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | -2.60695 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -2.55445 |
| SETD6 | SET domain containing 6 | -2.51815 |
| KRT23 | keratin 23, type I | -2.4442 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | -2.3022 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -2.25112 |
| TGM5 | transglutaminase 5 | -2.24165 |
| ORC6 | origin recognition complex, subunit 6 | -2.2383 |
| SLC25A16 | solute carrier family 25 (mitochondrial carrier), member 16 | -2.2354 |
| DPP8 | dipeptidyl-peptidase 8 | -2.2283 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -2.2101 |
| SAP25 | Sin3A-associated protein, 25kDa | -2.20852 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -2.1772 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -2.1729 |
| BRIX1 | BRX1, biogenesis of ribosomes | -2.16535 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -2.1596 |
| ANKRD10 | ankyrin repeat domain 10 | -2.15245 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -2.14485 |
| RNF111 | ring finger protein 111 | -2.14375 |
| PCTP | phosphatidylcholine transfer protein | -2.1434 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.12587 |
| BICRA | BRD4 interacting chromatin remodeling complex associated protein | -2.1214 |
| CD5L | CD5 molecule-like | -2.1154 |
| LRFN4 | leucine rich repeat and fibronectin type III domain containing 4 | -2.09535 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | -2.094 |
| TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | -2.0601 |
| PRRG4 | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | -2.03105 |
| NEFH | neurofilament, heavy polypeptide | -2.0187 |
| WASHC4 | WASH complex subunit 4 | -2.01622 |
| PYCARD | PYD and CARD domain containing | -2.00755 |
| INSIG1 | insulin induced gene 1 | -2.00155 |
