CRCGN012_HEPG2_24H:I06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 0.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN012_HEPG2_24H:I06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 8.6126
E2F2 E2F transcription factor 2 8.30803
NR1H2 nuclear receptor subfamily 1, group H, member 2 6.63574
LAGE3 L antigen family, member 3 5.44658
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 5.43005
AMDHD2 amidohydrolase domain containing 2 5.22006
STIMATE STIM activating enhancer 5.18229
INTS3 integrator complex subunit 3 5.16716
ATP11B ATPase, class VI, type 11B 5.08688
CARMIL1 capping protein regulator and myosin 1 linker 1 5.01754
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.99316
ABHD6 abhydrolase domain containing 6 4.93288
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.83657
ADGRE5 adhesion G protein-coupled receptor E5 4.60027
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.49995
PPARG peroxisome proliferator-activated receptor gamma 4.44614
JADE2 jade family PHD finger 2 4.39178
CSK c-src tyrosine kinase 4.37508
IDE insulin-degrading enzyme 4.26411
HDGFL3 HDGF like 3 3.98875
SNAP25 synaptosomal-associated protein, 25kDa 3.92272
GARRE1 granule associated Rac and RHOG effector 1 3.87727
NFIL3 nuclear factor, interleukin 3 regulated 3.84946
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.77383
SPOUT1 SPOUT domain containing methyltransferase 1 3.64358
CNPY3 canopy FGF signaling regulator 3 3.56224
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.55601
MAP7 microtubule-associated protein 7 3.31187
NOTCH1 notch 1 2.99492
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.98658
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.86666
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.66759
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.61844
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.56467
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.56425
LOC122526780 uncharacterized LOC122526780 2.54435
KIFBP kinesin family binding protein 2.5386
LGI2 leucine-rich repeat LGI family, member 2 2.39846
BLMH bleomycin hydrolase 2.39507
MLF1 myeloid leukemia factor 1 2.39097
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.37176
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 2.3708
AGO2 argonaute RISC catalytic component 2 2.35698
E2F5 E2F transcription factor 5, p130-binding 2.35623
SSH3 slingshot protein phosphatase 3 2.33795
WDR70 WD repeat domain 70 2.31486
GPER1 G protein-coupled estrogen receptor 1 2.3004
ASF1B anti-silencing function 1B histone chaperone 2.27223
YIPF2 Yip1 domain family, member 2 2.26222
RFXAP regulatory factor X-associated protein 2.25857
HOOK2 hook microtubule-tethering protein 2 2.25614
MATN4 matrilin 4 2.24896
CHN1 chimerin 1 2.22451
SPRED2 sprouty-related, EVH1 domain containing 2 2.21891
URM1 ubiquitin related modifier 1 2.18305
AQP1 aquaporin 1 (Colton blood group) 2.17745
LPAR2 lysophosphatidic acid receptor 2 2.17099
RAB28 RAB28, member RAS oncogene family 2.14684
PYCR1 pyrroline-5-carboxylate reductase 1 2.13787
RFXANK regulatory factor X-associated ankyrin-containing protein 2.1344
SCRG1 stimulator of chondrogenesis 1 2.12261
ZNF668 zinc finger protein 668 2.121
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.11412
ZFAND3 zinc finger, AN1-type domain 3 2.11206
SYCP2 synaptonemal complex protein 2 2.10701
EXOC3 exocyst complex component 3 2.1066
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.1066
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.07595
LEFTY2 left-right determination factor 2 2.06718
TIAM1 T-cell lymphoma invasion and metastasis 1 2.06646
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.05111
BRD3OS BRD3 opposite strand 2.04246
LMX1B LIM homeobox transcription factor 1, beta 2.04212
MYNN myoneurin 2.03607
AHNAK2 AHNAK nucleoprotein 2 2.03374
GPR20 G protein-coupled receptor 20 2.01879
VRTN vertebrae development associated 2.01738
FXN frataxin 2.01356
MFAP2 microfibrillar-associated protein 2 2.00286
FZD7 frizzled class receptor 7 2.00015

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.8602
ADI1 acireductone dioxygenase 1 -8.32758
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.13876
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.04825
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.77274
LOC124907782 dual specificity protein phosphatase 22 -6.03652
PCNA proliferating cell nuclear antigen -5.63345
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.34981
RFC2 replication factor C (activator 1) 2, 40kDa -5.22142
CCNB1 cyclin B1 -5.1522
ZDHHC6 zinc finger, DHHC-type containing 6 -5.08863
ALAS1 5'-aminolevulinate synthase 1 -5.08374
TRIB3 tribbles pseudokinase 3 -5.05453
DNM1L dynamin 1-like -5.00013
NT5DC2 5'-nucleotidase domain containing 2 -4.98283
LDHD lactate dehydrogenase D -4.95533
EGF epidermal growth factor -3.82737
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.81413
FASTKD5 FAST kinase domains 5 -3.62745
YME1L1 YME1-like 1 ATPase -3.62476
MAPK13 mitogen-activated protein kinase 13 -3.21024
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.19548
EIF5 eukaryotic translation initiation factor 5 -3.16835
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -3.07779
KDM3A lysine (K)-specific demethylase 3A -3.03317
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.02855
SLC35F2 solute carrier family 35, member F2 -2.78443
CHMP4B charged multivesicular body protein 4B -2.72645
BTN2A1 butyrophilin, subfamily 2, member A1 -2.72091
CLTB clathrin, light chain B -2.66053
SESN1 sestrin 1 -2.56426
WDR37 WD repeat domain 37 -2.54369
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.53435
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -2.49984
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.48138
ANKRD10 ankyrin repeat domain 10 -2.45211
ESYT1 extended synaptotagmin-like protein 1 -2.43784
TMEM97 transmembrane protein 97 -2.32904
WASHC4 WASH complex subunit 4 -2.31959
HEXB hexosaminidase B (beta polypeptide) -2.2563
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.21654
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.20765
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.18307
SMYD2 SET and MYND domain containing 2 -2.14999
STAT1 signal transducer and activator of transcription 1, 91kDa -2.13395
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.12326
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.07443
LEMD3 LEM domain containing 3 -2.03008
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.0244
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0075
MRPS17 mitochondrial ribosomal protein S17 -2.00431