CRCGN012_HEPG2_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 21.08 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN012_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.76131
STAP2 signal transducing adaptor family member 2 4.64714
CSK c-src tyrosine kinase 4.25728
JADE2 jade family PHD finger 2 4.01699
CCNF cyclin F 3.51277
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.47272
TATDN2 TatD DNase domain containing 2 3.15756
EPHA3 EPH receptor A3 2.85689
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.78626
CIAO3 cytosolic iron-sulfur assembly component 3 2.58096
PMM2 phosphomannomutase 2 2.54313
LCN2 lipocalin 2 2.51293
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.34514
RAB4A RAB4A, member RAS oncogene family 2.33737
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.33239
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.28748
SKIC2 SKI2 subunit of superkiller complex 2.24387
PIH1D1 PIH1 domain containing 1 2.18935
CBR3 carbonyl reductase 3 2.1717
KIF20A kinesin family member 20A 2.12272
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.08899
PGAM4 phosphoglycerate mutase family member 4 2.02753

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.73046
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.84424
GNAS GNAS complex locus -5.22163
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.09362
KDM3A lysine (K)-specific demethylase 3A -4.9974
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.89099
CDC20 cell division cycle 20 -4.81277
UBE3C ubiquitin protein ligase E3C -4.55568
CCNB1 cyclin B1 -4.15411
WASHC4 WASH complex subunit 4 -3.43371
ZNF586 zinc finger protein 586 -3.34222
OXA1L oxidase (cytochrome c) assembly 1-like -2.84226
EIF5 eukaryotic translation initiation factor 5 -2.55167
TCTN1 tectonic family member 1 -2.36246
RPS5 ribosomal protein S5 -2.30396
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.20508
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.16822
SSBP2 single-stranded DNA binding protein 2 -2.09531
HMG20B high mobility group 20B -2.04999
CTNND1 catenin (cadherin-associated protein), delta 1 -2.0081