CRCGN012_HEPG2_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 10.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

121 genes differentially expressed following the CRCGN012_HEPG2_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.13428
E2F2 E2F transcription factor 2 5.04981
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.68159
CHN1 chimerin 1 4.67801
STIMATE STIM activating enhancer 4.65629
RPP38 ribonuclease P/MRP 38kDa subunit 4.28552
TIAM1 T-cell lymphoma invasion and metastasis 1 4.11543
HOXA10 homeobox A10 3.98053
MYLK myosin light chain kinase 3.95888
PNKP polynucleotide kinase 3'-phosphatase 3.70206
CSK c-src tyrosine kinase 3.66375
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.54587
UBQLN2 ubiquilin 2 3.50963
JADE2 jade family PHD finger 2 3.48235
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.31651
RXYLT1 ribitol xylosyltransferase 1 3.30283
GPER1 G protein-coupled estrogen receptor 1 3.17437
STK10 serine/threonine kinase 10 3.13401
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.045
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.9155
CGRRF1 cell growth regulator with ring finger domain 1 2.90357
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.8633
GSTZ1 glutathione S-transferase zeta 1 2.85291
PFKL phosphofructokinase, liver 2.8295
MYBPC1 myosin binding protein C, slow type 2.8038
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.78296
ASIC2 acid sensing (proton gated) ion channel 2 2.78001
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.72331
MYOT myotilin 2.63985
RPL39L ribosomal protein L39-like 2.63877
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.60346
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.59844
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.57176
EVL Enah/Vasp-like 2.54805
MAST2 microtubule associated serine/threonine kinase 2 2.49374
SNAP25 synaptosomal-associated protein, 25kDa 2.49055
CCNF cyclin F 2.46106
OPCML opioid binding protein/cell adhesion molecule-like 2.41886
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.41614
SORBS3 sorbin and SH3 domain containing 3 2.41582
CA10 carbonic anhydrase X 2.41292
FAIM2 Fas apoptotic inhibitory molecule 2 2.39585
EPN2 epsin 2 2.35985
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.33687
DNAL4 dynein, axonemal, light chain 4 2.3305
MEF2C myocyte enhancer factor 2C 2.31048
SYNM synemin, intermediate filament protein 2.30771
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.27342
PRRX2 paired related homeobox 2 2.26901
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.23854
ANKRD17 ankyrin repeat domain 17 2.23689
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.22532
KIAA0586 KIAA0586 2.22496
CKM creatine kinase, muscle 2.22477
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.21985
ANO10 anoctamin 10 2.1844
KCNIP1 Kv channel interacting protein 1 2.18378
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.18373
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 2.17811
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.17528
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.17422
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.16548
LRRC20 leucine rich repeat containing 20 2.14053
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.13911
CDH10 cadherin 10, type 2 (T2-cadherin) 2.11195
MCM3 minichromosome maintenance complex component 3 2.10405
TRAK2 trafficking protein, kinesin binding 2 2.08939
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.0863
DENND2D DENN/MADD domain containing 2D 2.07509
CERS4 ceramide synthase 4 2.02906
SHBG sex hormone-binding globulin 2.02725
NRSN2 neurensin 2 2.0204

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.15414
CDC20 cell division cycle 20 -7.46412
ZNF586 zinc finger protein 586 -7.45607
PUF60 poly-U binding splicing factor 60KDa -6.45757
ADI1 acireductone dioxygenase 1 -6.04675
RHEB Ras homolog enriched in brain -3.95992
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.94645
THAP11 THAP domain containing 11 -3.89739
GDF15 growth differentiation factor 15 -3.67141
KDM3A lysine (K)-specific demethylase 3A -3.54257
LOC124907782 dual specificity protein phosphatase 22 -3.38954
VAT1 vesicle amine transport 1 -3.27197
COG2 component of oligomeric golgi complex 2 -3.12495
RFC2 replication factor C (activator 1) 2, 40kDa -2.97721
LDHD lactate dehydrogenase D -2.95522
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.92256
CCNB2 cyclin B2 -2.89431
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.8431
MEST mesoderm specific transcript -2.70979
GOLT1B golgi transport 1B -2.70112
OXA1L oxidase (cytochrome c) assembly 1-like -2.67196
MRPL15 mitochondrial ribosomal protein L15 -2.6641
REEP5 receptor accessory protein 5 -2.53916
TRAP1 TNF receptor-associated protein 1 -2.5352
MTFR1 mitochondrial fission regulator 1 -2.52708
DNM1L dynamin 1-like -2.51667
ZNF551 zinc finger protein 551 -2.41879
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.39769
ZNF93 zinc finger protein 93 -2.27872
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.25599
ZNF761 zinc finger protein 761 -2.24502
FGFR4 fibroblast growth factor receptor 4 -2.23293
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.2143
ANKRD11 ankyrin repeat domain 11 -2.21091
SCGB2A1 secretoglobin, family 2A, member 1 -2.20824
MAP7 microtubule-associated protein 7 -2.20251
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.17251
IST1 increased sodium tolerance 1 homolog (yeast) -2.16333
SCRIB scribbled planar cell polarity protein -2.15066
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.09271
ZNF253 zinc finger protein 253 -2.08024
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.08024
HLA-DMA major histocompatibility complex, class II, DM alpha -2.07219
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.05822
PRCP prolylcarboxypeptidase (angiotensinase C) -2.03777
FASTKD5 FAST kinase domains 5 -2.03194
DEPTOR DEP domain containing MTOR-interacting protein -2.02519
ZNF212 zinc finger protein 212 -2.01133
VDAC1 voltage-dependent anion channel 1 -2.00024