| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 5.27 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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79 genes differentially expressed following the CRCGN012_HEPG2_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBQLN2 | ubiquilin 2 | 7.72654 |
| LCN2 | lipocalin 2 | 7.70597 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 7.61688 |
| E2F2 | E2F transcription factor 2 | 6.27316 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.05498 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.99991 |
| PRKCH | protein kinase C, eta | 4.84343 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.89418 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.79251 |
| CCDC92 | coiled-coil domain containing 92 | 3.78209 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.66942 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.63719 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.58995 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.5578 |
| CCNF | cyclin F | 3.34378 |
| EPHB2 | EPH receptor B2 | 3.28621 |
| EGF | epidermal growth factor | 2.9742 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.8011 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 2.65655 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.64657 |
| MAGEH1 | melanoma antigen family H1 | 2.64538 |
| CHEK2 | checkpoint kinase 2 | 2.52999 |
| EDN1 | endothelin 1 | 2.4831 |
| PWP2 | PWP2 periodic tryptophan protein homolog (yeast) | 2.46656 |
| PFKL | phosphofructokinase, liver | 2.3848 |
| SLC75A1 | solute carrier family 75 member 1 | 2.32485 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.2887 |
| PCDHB11 | protocadherin beta 11 | 2.27249 |
| TCIM | transcriptional and immune response regulator | 2.26628 |
| GATD3 | glutamine amidotransferase class 1 domain containing 3 | 2.21634 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.2143 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.13035 |
| CENPS-CORT | CENPS-CORT readthrough | 2.12458 |
| CHMP6 | charged multivesicular body protein 6 | 2.08846 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.08843 |
| WDR7 | WD repeat domain 7 | 2.03417 |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | 2.01616 |
| RPL39L | ribosomal protein L39-like | 2.01544 |
| COL5A1 | collagen, type V, alpha 1 | 2.00895 |
| SDHAF1 | succinate dehydrogenase complex assembly factor 1 | 2.00494 |
| MXRA8 | matrix-remodelling associated 8 | 2.00393 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIB3 | tribbles pseudokinase 3 | -10.0 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -9.11246 |
| VAT1 | vesicle amine transport 1 | -7.8869 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.94216 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -5.47269 |
| ADI1 | acireductone dioxygenase 1 | -4.87283 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.65285 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.89722 |
| CCNB1 | cyclin B1 | -3.73899 |
| ZNF586 | zinc finger protein 586 | -3.51559 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.40463 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.38413 |
| NGRN | neugrin, neurite outgrowth associated | -3.38048 |
| RPS5 | ribosomal protein S5 | -3.23583 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.21692 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.00225 |
| NCK1 | NCK adaptor protein 1 | -2.89834 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.76429 |
| VDAC1 | voltage-dependent anion channel 1 | -2.5623 |
| PEG10 | paternally expressed 10 | -2.56168 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.54745 |
| WASHC4 | WASH complex subunit 4 | -2.54106 |
| CDC20 | cell division cycle 20 | -2.42213 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.30814 |
| PLA1A | phospholipase A1 member A | -2.25136 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.24234 |
| MVP | major vault protein | -2.21439 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.18872 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.18623 |
| TLCD3A | TLC domain containing 3A | -2.1526 |
| ZNF638 | zinc finger protein 638 | -2.13813 |
| PNPLA3 | patatin-like phospholipase domain containing 3 | -2.07807 |
| MTIF2 | mitochondrial translational initiation factor 2 | -2.07727 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.07257 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.05118 |
| FAT1 | FAT atypical cadherin 1 | -2.02149 |
| AFTPH | aftiphilin | -2.01452 |
| FBXO7 | F-box protein 7 | -2.00303 |
