| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 2.64 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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53 genes differentially expressed following the CRCGN012_HEPG2_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.95866 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 6.47418 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.7431 |
| CHN1 | chimerin 1 | 4.30076 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 3.77433 |
| MPC2 | mitochondrial pyruvate carrier 2 | 3.60624 |
| MSRA | methionine sulfoxide reductase A | 3.50766 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.49995 |
| CBR3 | carbonyl reductase 3 | 3.14184 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.08981 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 3.02312 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.97752 |
| ATP11B | ATPase, class VI, type 11B | 2.94553 |
| RAB21 | RAB21, member RAS oncogene family | 2.88158 |
| MELK | maternal embryonic leucine zipper kinase | 2.78109 |
| LOC122526780 | uncharacterized LOC122526780 | 2.74576 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.72819 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.72726 |
| LCN2 | lipocalin 2 | 2.58192 |
| CHMP6 | charged multivesicular body protein 6 | 2.57497 |
| TLR4 | toll-like receptor 4 | 2.56452 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.43289 |
| STXBP2 | syntaxin binding protein 2 | 2.31914 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.3081 |
| KIF5C | kinesin family member 5C | 2.25641 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.22648 |
| EVL | Enah/Vasp-like | 2.22177 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.1825 |
| FZD7 | frizzled class receptor 7 | 2.08182 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.06632 |
| HBQ1 | hemoglobin, theta 1 | 2.01689 |
| CYCS | cytochrome c, somatic | 2.01101 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC35F2 | solute carrier family 35, member F2 | -4.42249 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.97691 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.70136 |
| TRIB3 | tribbles pseudokinase 3 | -3.65057 |
| CCDC86 | coiled-coil domain containing 86 | -3.50401 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.47593 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.474 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.31679 |
| THAP11 | THAP domain containing 11 | -3.3084 |
| LDHD | lactate dehydrogenase D | -3.10476 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.00986 |
| NUP93 | nucleoporin 93kDa | -2.82588 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.66625 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.65108 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.56935 |
| GOLT1B | golgi transport 1B | -2.39066 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.25252 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.248 |
| SPAG4 | sperm associated antigen 4 | -2.21832 |
| AURKB | aurora kinase B | -2.06082 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.04265 |
