| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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58 genes differentially expressed following the CRCGN012_HEPG2_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPER1 | G protein-coupled estrogen receptor 1 | 5.30864 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.20504 |
| GPATCH8 | G patch domain containing 8 | 4.33976 |
| STIMATE | STIM activating enhancer | 4.01358 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 4.01291 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.89324 |
| MYLK | myosin light chain kinase | 3.86583 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.77364 |
| CSK | c-src tyrosine kinase | 3.74861 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.58858 |
| NMU | neuromedin U | 3.51135 |
| CYCS | cytochrome c, somatic | 3.42777 |
| MEF2C | myocyte enhancer factor 2C | 3.378 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 3.27503 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.06372 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 3.04631 |
| ABHD6 | abhydrolase domain containing 6 | 2.98283 |
| ZNF589 | zinc finger protein 589 | 2.71238 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.65811 |
| ADAM10 | ADAM metallopeptidase domain 10 | 2.56946 |
| NOSIP | nitric oxide synthase interacting protein | 2.54462 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.53714 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.24032 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.23523 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.22921 |
| KIF14 | kinesin family member 14 | 2.1954 |
| DERL2 | derlin 2 | 2.11626 |
| YIPF1 | Yip1 domain family, member 1 | 2.0505 |
| ICAM1 | intercellular adhesion molecule 1 | 2.03927 |
| NLRP2B | NLR family pyrin domain containing 2B | 2.02446 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.0045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.07626 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.22122 |
| PCNA | proliferating cell nuclear antigen | -4.15522 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.12076 |
| UBE3C | ubiquitin protein ligase E3C | -4.06447 |
| EGF | epidermal growth factor | -4.04275 |
| ISOC1 | isochorismatase domain containing 1 | -3.87521 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.81104 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.56238 |
| VAT1 | vesicle amine transport 1 | -3.45577 |
| CCNB2 | cyclin B2 | -3.43172 |
| CCNB1 | cyclin B1 | -3.35905 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -3.32374 |
| LDHD | lactate dehydrogenase D | -3.29991 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.2248 |
| ADI1 | acireductone dioxygenase 1 | -3.21917 |
| WASHC4 | WASH complex subunit 4 | -3.11018 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.05784 |
| CDC25B | cell division cycle 25B | -2.84717 |
| VDAC1 | voltage-dependent anion channel 1 | -2.82798 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.53816 |
| ZW10 | zw10 kinetochore protein | -2.5134 |
| LYPLA1 | lysophospholipase I | -2.41494 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.3698 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.20055 |
| DENND10 | DENN domain containing 10 | -2.12235 |
| MSH6 | mutS homolog 6 | -2.0549 |
