CRCGN012_HEPG2_24H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN012_HEPG2_24H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
E2F2 E2F transcription factor 2 5.97846
MOK MOK protein kinase 4.91406
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.52117
CIAO3 cytosolic iron-sulfur assembly component 3 4.40779
LCN2 lipocalin 2 4.31701
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.30413
SIRT3 sirtuin 3 3.94142
CSK c-src tyrosine kinase 3.91071
DNM1 dynamin 1 3.82393
ZNF589 zinc finger protein 589 3.56061
CRTAP cartilage associated protein 3.46099
CCL2 chemokine (C-C motif) ligand 2 3.42996
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.29106
PEX11A peroxisomal biogenesis factor 11 alpha 3.28849
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.2716
AXIN1 axin 1 3.24987
SNAP25 synaptosomal-associated protein, 25kDa 3.1537
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.92631
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.91582
MAMLD1 mastermind-like domain containing 1 2.89183
CHN1 chimerin 1 2.89067
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.86803
FPGS folylpolyglutamate synthase 2.85478
ADGRE5 adhesion G protein-coupled receptor E5 2.85021
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.77662
ALDOC aldolase C, fructose-bisphosphate 2.76054
GPER1 G protein-coupled estrogen receptor 1 2.75169
ABHD4 abhydrolase domain containing 4 2.70688
CCNF cyclin F 2.70193
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.64865
EVL Enah/Vasp-like 2.60532
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.54776
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.52377
NCKIPSD NCK interacting protein with SH3 domain 2.4783
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.44626
ANXA3 annexin A3 2.41666
VSNL1 visinin-like 1 2.39852
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.38922
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.35682
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.34829
FCHO1 FCH domain only 1 2.31195
NTSR2 neurotensin receptor 2 2.28305
NOSIP nitric oxide synthase interacting protein 2.2576
PRUNE1 prune exopolyphosphatase 1 2.23306
DIPK1A divergent protein kinase domain 1A 2.22156
SP4 Sp4 transcription factor 2.2097
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.19009
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.17318
EPHA3 EPH receptor A3 2.16253
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.14145
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.13621
BPY2B basic charge, Y-linked, 2B 2.13448
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.12544
VCY1B variable charge, Y-linked 1B 2.12251
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.10953
DEAF1 DEAF1 transcription factor 2.10764
GPR22 G protein-coupled receptor 22 2.10319
CCDC186 coiled-coil domain containing 186 2.0949
MELTF melanotransferrin 2.09068
IFNA21 interferon, alpha 21 2.0855
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.08031
VGLL4 vestigial-like family member 4 2.07667
SNCB synuclein, beta 2.07419
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.06282
BHLHE40 basic helix-loop-helix family, member e40 2.06007
TUBB4A tubulin, beta 4A class IVa 2.05021
LGI1 leucine-rich, glioma inactivated 1 2.04344
METTL16 methyltransferase like 16 2.03144
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.02822
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.02637
MYO3A myosin IIIA 2.02027
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.00358

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -6.42781
TLCD3A TLC domain containing 3A -5.75986
TCTN1 tectonic family member 1 -5.51965
CAB39 calcium binding protein 39 -5.21913
ZMIZ1 zinc finger, MIZ-type containing 1 -5.0027
NGRN neugrin, neurite outgrowth associated -4.84835
CDC20 cell division cycle 20 -4.71642
CRELD2 cysteine-rich with EGF-like domains 2 -4.61924
LDHD lactate dehydrogenase D -4.60155
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.47074
CCNB2 cyclin B2 -3.75157
TBC1D10C TBC1 domain family, member 10C -3.72649
FASTKD5 FAST kinase domains 5 -3.68286
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.6761
ENOPH1 enolase-phosphatase 1 -3.40174
FBXL12 F-box and leucine-rich repeat protein 12 -3.29305
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.22793
SLC35F2 solute carrier family 35, member F2 -3.19606
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.18567
CARMIL1 capping protein regulator and myosin 1 linker 1 -3.02679
MAPK13 mitogen-activated protein kinase 13 -2.91291
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.82816
CRYZ crystallin, zeta (quinone reductase) -2.71477
NLRP4 NLR family, pyrin domain containing 4 -2.69395
DYNLT3 dynein, light chain, Tctex-type 3 -2.50755
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.45645
EIF5 eukaryotic translation initiation factor 5 -2.42378
TRIB3 tribbles pseudokinase 3 -2.35422
MAD2L1BP MAD2L1 binding protein -2.34302
RBM15 RNA binding motif protein 15 -2.28597
MALT1 MALT1 paracaspase -2.27972
TMEM260 transmembrane protein 260 -2.27173
HSPA1A heat shock 70kDa protein 1A -2.25549
GLOD4 glyoxalase domain containing 4 -2.22517
TBX2 T-box 2 -2.18159
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.15257
RNF4 ring finger protein 4 -2.1469
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.14064
UBE3C ubiquitin protein ligase E3C -2.10569
FCGBP Fc fragment of IgG binding protein -2.00536
PITPNA phosphatidylinositol transfer protein, alpha -2.0