CRCGN012_HEPG2_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 5.08 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN012_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.18004
CYCS cytochrome c, somatic 4.16302
RPL39L ribosomal protein L39-like 4.05972
MAMLD1 mastermind-like domain containing 1 3.68384
GATA3 GATA binding protein 3 3.24278
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.96175
MSRA methionine sulfoxide reductase A 2.91025
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.83282
STIMATE STIM activating enhancer 2.57646
NLRP2B NLR family pyrin domain containing 2B 2.5311
CXCR4 chemokine (C-X-C motif) receptor 4 2.50642
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.45322
CARMIL1 capping protein regulator and myosin 1 linker 1 2.42629
CEP57 centrosomal protein 57kDa 2.32375
LRRC20 leucine rich repeat containing 20 2.11456
CBR3 carbonyl reductase 3 2.06397

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.22837
PCNA proliferating cell nuclear antigen -5.55201
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.16471
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.97139
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.76297
ZNF586 zinc finger protein 586 -3.71271
VAT1 vesicle amine transport 1 -3.65634
KDM3A lysine (K)-specific demethylase 3A -3.48206
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.38774
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.35323
DNM1L dynamin 1-like -3.34477
LDHD lactate dehydrogenase D -3.26822
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.15903
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.14735
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.07867
SESN1 sestrin 1 -2.70591
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.69735
CDC25B cell division cycle 25B -2.5464
CHMP4B charged multivesicular body protein 4B -2.51271
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.32814
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3126
SSBP2 single-stranded DNA binding protein 2 -2.30417
CRTAP cartilage associated protein -2.19026
TMEM147 transmembrane protein 147 -2.15293
CTCF CCCTC-binding factor (zinc finger protein) -2.05606
BRD7 bromodomain containing 7 -2.0518
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.02949
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.01245
RBM15B RNA binding motif protein 15B -2.00075