| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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59 genes differentially expressed following the CRCGN012_HEPG2_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.37907 |
| STIMATE | STIM activating enhancer | 4.16767 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.45207 |
| STK10 | serine/threonine kinase 10 | 3.43952 |
| MYLK | myosin light chain kinase | 3.43733 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.23833 |
| SQOR | sulfide quinone oxidoreductase | 3.20323 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.1867 |
| TMEM50A | transmembrane protein 50A | 3.13797 |
| MAMLD1 | mastermind-like domain containing 1 | 3.09653 |
| STAP2 | signal transducing adaptor family member 2 | 3.0878 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.044 |
| NOTCH1 | notch 1 | 3.0272 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 2.9572 |
| UBQLN2 | ubiquilin 2 | 2.95653 |
| E2F2 | E2F transcription factor 2 | 2.87073 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.81507 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.76703 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 2.74053 |
| RAB21 | RAB21, member RAS oncogene family | 2.73013 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 2.65403 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 2.60542 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.53333 |
| MCM3 | minichromosome maintenance complex component 3 | 2.48677 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.4439 |
| CHN1 | chimerin 1 | 2.40023 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.3936 |
| HOXA10 | homeobox A10 | 2.32498 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.23945 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.2212 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.19064 |
| FPGS | folylpolyglutamate synthase | 2.0777 |
| NPR1 | natriuretic peptide receptor 1 | 2.01848 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.01037 |
| RABL3 | RAB, member of RAS oncogene family-like 3 | 2.0093 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -6.29197 |
| NISCH | nischarin | -6.20677 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.83953 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -4.25943 |
| CDC25B | cell division cycle 25B | -4.15623 |
| SMNDC1 | survival motor neuron domain containing 1 | -3.9643 |
| TSPAN4 | tetraspanin 4 | -3.87672 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.67153 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -3.62307 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.6201 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -3.4825 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.30067 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.17013 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.96347 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -2.74143 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.55283 |
| CASC3 | cancer susceptibility candidate 3 | -2.51557 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -2.23968 |
| S100A4 | S100 calcium binding protein A4 | -2.23797 |
| NGRN | neugrin, neurite outgrowth associated | -2.2177 |
| COMMD3-BMI1 | COMMD3-BMI1 readthrough | -2.16743 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.14126 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.13463 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -2.0782 |
