CRCGN012_HEPG2_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN012_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.30601
CHMP6 charged multivesicular body protein 6 6.86445
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.12958
LCN2 lipocalin 2 4.77192
TAC4 tachykinin 4 (hemokinin) 4.67614
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.54476
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.70467
HOXA10 homeobox A10 3.65134
PRKCH protein kinase C, eta 3.5935
LPAR2 lysophosphatidic acid receptor 2 3.24276
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.80881
IFI6 interferon, alpha-inducible protein 6 2.71453
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.6409
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.63205
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.59016
IFI44L interferon-induced protein 44-like 2.56954
ISG15 ISG15 ubiquitin-like modifier 2.53617
MX1 MX dynamin-like GTPase 1 2.51136
NMU neuromedin U 2.43633
PARP12 poly (ADP-ribose) polymerase family, member 12 2.37646
RSAD2 radical S-adenosyl methionine domain containing 2 2.33209
RPL39L ribosomal protein L39-like 2.31947
CCNF cyclin F 2.31213
HDGFL3 HDGF like 3 2.30725
IFI35 interferon-induced protein 35 2.2778
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.27593
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.25585
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.1904
BACE2 beta-site APP-cleaving enzyme 2 2.1693
RIGI RNA sensor RIG-I 2.1665
ADRB2 adrenoceptor beta 2, surface 2.12425
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.11961
E2F2 E2F transcription factor 2 2.04894
IFI27 interferon, alpha-inducible protein 27 2.04849
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.04367
PLA2G12A phospholipase A2, group XIIA 2.04111
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.01833

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -7.67395
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.37867
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.81005
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.54106
VDAC1 voltage-dependent anion channel 1 -3.92834
OXA1L oxidase (cytochrome c) assembly 1-like -3.82403
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.84021
MRPS2 mitochondrial ribosomal protein S2 -2.78922
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.64292
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.53818
TRIB3 tribbles pseudokinase 3 -2.41132
MAPK13 mitogen-activated protein kinase 13 -2.37789
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.30752
SSBP2 single-stranded DNA binding protein 2 -2.27874
GET1 guided entry of tail-anchored proteins factor 1 -2.26271
ADI1 acireductone dioxygenase 1 -2.25682
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.25453
YME1L1 YME1-like 1 ATPase -2.19048
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.11934
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.02575