CRCGN012_HEPG2_24H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 19.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

665 genes differentially expressed following the CRCGN012_HEPG2_24H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 7.64115
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 7.2289
TRIB3 tribbles pseudokinase 3 7.00275
INPP1 inositol polyphosphate-1-phosphatase 6.97045
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 6.50285
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 6.37945
LRP10 low density lipoprotein receptor-related protein 10 6.34765
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.23445
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.87115
GFPT1 glutamine--fructose-6-phosphate transaminase 1 5.83395
EGR1 early growth response 1 5.79918
ABHD4 abhydrolase domain containing 4 5.54785
PRKCH protein kinase C, eta 5.5296
SQSTM1 sequestosome 1 5.48697
GPATCH8 G patch domain containing 8 5.15855
TXNRD1 thioredoxin reductase 1 5.1574
CDPF1 cysteine-rich, DPF motif domain containing 1 5.1393
DDIT4 DNA-damage-inducible transcript 4 5.11405
STK10 serine/threonine kinase 10 5.1061
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.05645
STX1A syntaxin 1A (brain) 5.00595
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.8265
IER3 immediate early response 3 4.8118
GRB10 growth factor receptor-bound protein 10 4.78897
SLC75A1 solute carrier family 75 member 1 4.7638
LCN2 lipocalin 2 4.70145
MBNL2 muscleblind-like splicing regulator 2 4.59528
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.5884
PRAF2 PRA1 domain family, member 2 4.45055
SARS1 seryl-tRNA synthetase 1 4.4243
CBR3 carbonyl reductase 3 4.3899
IL4R interleukin 4 receptor 4.3393
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.25
TM9SF2 transmembrane 9 superfamily member 2 4.1886
GLRX glutaredoxin (thioltransferase) 4.04555
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.977
VAT1 vesicle amine transport 1 3.96995
ABHD6 abhydrolase domain containing 6 3.94703
TERF2IP telomeric repeat binding factor 2, interacting protein 3.87685
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 3.85615
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 3.7962
ACOT9 acyl-CoA thioesterase 9 3.7893
PRR15L proline rich 15-like 3.77205
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 3.76858
YARS1 tyrosyl-tRNA synthetase 1 3.7423
UGDH UDP-glucose 6-dehydrogenase 3.7266
SYNGAP1 synaptic Ras GTPase activating protein 1 3.63225
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.60853
WDR7 WD repeat domain 7 3.588
MAPK13 mitogen-activated protein kinase 13 3.58028
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.5748
ATF6 activating transcription factor 6 3.57468
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 3.57
EXD2 exonuclease 3'-5' domain containing 2 3.56125
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.5558
FOSL1 FOS-like antigen 1 3.4684
SMAD3 SMAD family member 3 3.45776
SQOR sulfide quinone oxidoreductase 3.4562
GOLT1B golgi transport 1B 3.45595
CYCS cytochrome c, somatic 3.45015
AARS1 alanyl-tRNA synthetase 1 3.44385
TEX10 testis expressed 10 3.4414
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.41255
IARS1 isoleucyl-tRNA synthetase 1 3.39965
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.3336
GARS1 glycyl-tRNA synthetase 1 3.31175
TRIB1 tribbles pseudokinase 1 3.28955
NGRN neugrin, neurite outgrowth associated 3.28815
KIFBP kinesin family binding protein 3.2691
TGFB1I1 transforming growth factor beta 1 induced transcript 1 3.2643
CAB39 calcium binding protein 39 3.21775
CNPY3 canopy FGF signaling regulator 3 3.20635
SH2B3 SH2B adaptor protein 3 3.1502
INSIG1 insulin induced gene 1 3.12523
LOC128125814 uncharacterized LOC128125814 3.1203
MALT1 MALT1 paracaspase 3.11472
ATF4 activating transcription factor 4 3.0835
CGRRF1 cell growth regulator with ring finger domain 1 3.07465
PLK3 polo-like kinase 3 3.0436
ZFP69B ZFP69 zinc finger protein B 3.01505
TIMP2 TIMP metallopeptidase inhibitor 2 3.00645
ARFIP2 ADP-ribosylation factor interacting protein 2 3.00015
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.99257
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.9836
TMEM184C transmembrane protein 184C 2.98045
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.97457
INHBE inhibin, beta E 2.9717
ATG7 autophagy related 7 2.9654
FKBP14 FK506 binding protein 14, 22 kDa 2.94055
SCYL3 SCY1-like 3 (S. cerevisiae) 2.93762
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.909
KDM5A lysine (K)-specific demethylase 5A 2.88552
SLC35B1 solute carrier family 35, member B1 2.87705
TWF2 twinfilin actin binding protein 2 2.8491
TMEM50A transmembrane protein 50A 2.8479
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.841
PDGFA platelet-derived growth factor alpha polypeptide 2.83818
ARF4 ADP-ribosylation factor 4 2.83735
DSG2 desmoglein 2 2.82805
BECN1 beclin 1, autophagy related 2.8267
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.8088
VSIG2 V-set and immunoglobulin domain containing 2 2.80575
NECAP1 NECAP endocytosis associated 1 2.80005
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.7931
MVP major vault protein 2.7822
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.7809
LGALS8 lectin, galactoside-binding, soluble, 8 2.77518
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.76227
PHC2 polyhomeotic homolog 2 (Drosophila) 2.7369
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.71485
NARS1 asparaginyl-tRNA synthetase 1 2.71465
BIRC2 baculoviral IAP repeat containing 2 2.70955
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.70715
TMEM184B transmembrane protein 184B 2.70025
FXYD5 FXYD domain containing ion transport regulator 5 2.6897
HSPA13 heat shock protein 70kDa family, member 13 2.6866
ADGRE5 adhesion G protein-coupled receptor E5 2.68505
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.67855
PSEN1 presenilin 1 2.66738
ANO1 anoctamin 1, calcium activated chloride channel 2.66725
RPL18 ribosomal protein L18 2.6659
IFRD1 interferon-related developmental regulator 1 2.6649
CCPG1 cell cycle progression 1 2.66185
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.6495
SERINC3 serine incorporator 3 2.64204
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.63455
EIF6 eukaryotic translation initiation factor 6 2.624
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.62302
ZZZ3 zinc finger, ZZ-type containing 3 2.62205
RAP1GAP RAP1 GTPase activating protein 2.61725
CARS1 cysteinyl-tRNA synthetase 1 2.58975
YIPF4 Yip1 domain family, member 4 2.58885
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.5755
FPGS folylpolyglutamate synthase 2.5662
RBKS ribokinase 2.56245
TOMM34 translocase of outer mitochondrial membrane 34 2.55975
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.55505
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.54535
TIAM1 T-cell lymphoma invasion and metastasis 1 2.54043
H2BC12 H2B clustered histone 12 2.53502
STEEP1 STING1 ER exit protein 1 2.5285
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.51345
MICALL1 MICAL-like 1 2.4974
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.49318
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.49095
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.48885
ABLIM3 actin binding LIM protein family, member 3 2.47685
NPDC1 neural proliferation, differentiation and control, 1 2.4669
MED8 mediator complex subunit 8 2.4653
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.4514
SHB Src homology 2 domain containing adaptor protein B 2.44475
MINAR1 membrane integral NOTCH2 associated receptor 1 2.44285
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.4427
SLC12A8 solute carrier family 12, member 8 2.428
EEF2 eukaryotic translation elongation factor 2 2.42675
ZFYVE26 zinc finger, FYVE domain containing 26 2.42482
KDSR 3-ketodihydrosphingosine reductase 2.4116
SYNGR3 synaptogyrin 3 2.4104
RPS8 ribosomal protein S8 2.4037
MMRN1 multimerin 1 2.39255
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.38225
PNRC1 proline-rich nuclear receptor coactivator 1 2.37895
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.37582
OCLN occludin 2.3723
INTS6 integrator complex subunit 6 2.36495
USP6NL USP6 N-terminal like 2.3645
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.3636
GTPBP2 GTP binding protein 2 2.363
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.356
RPL10A ribosomal protein L10a 2.3508
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.343
MAP1B microtubule-associated protein 1B 2.34065
ZNF410 zinc finger protein 410 2.33313
TAS2R10 taste receptor, type 2, member 10 2.33025
OSMR oncostatin M receptor 2.3245
ITFG1 integrin alpha FG-GAP repeat containing 1 2.32405
INSIG2 insulin induced gene 2 2.32285
LIG4 ligase IV, DNA, ATP-dependent 2.3194
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.3116
EPHA3 EPH receptor A3 2.31118
EAPP E2F-associated phosphoprotein 2.30915
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.3091
TES testin LIM domain protein 2.2953
SYNPO synaptopodin 2.28655
MGP matrix Gla protein 2.2862
KLHL21 kelch-like family member 21 2.27415
S100A11 S100 calcium binding protein A11 2.2675
CYTL1 cytokine-like 1 2.2669
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.2554
EHD4 EH-domain containing 4 2.25425
PCNX1 pecanex 1 2.25082
MACO1 macoilin 1 2.24675
TM4SF1 transmembrane 4 L six family member 1 2.2406
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.23305
DUSP6 dual specificity phosphatase 6 2.23135
TARS1 threonyl-tRNA synthetase 1 2.2274
CDK7 cyclin-dependent kinase 7 2.22655
RALB v-ral simian leukemia viral oncogene homolog B 2.22475
NAPSA napsin A aspartic peptidase 2.22347
ATP11B ATPase, class VI, type 11B 2.22
EMC8 ER membrane protein complex subunit 8 2.20735
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.2058
KDM6B lysine (K)-specific demethylase 6B 2.2008
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.19335
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.1923
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.18615
LRP1B low density lipoprotein receptor-related protein 1B 2.1837
DHRS3 dehydrogenase/reductase (SDR family) member 3 2.1806
SOX4 SRY (sex determining region Y)-box 4 2.17742
PLIN3 perilipin 3 2.17185
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2.16242
KDM3A lysine (K)-specific demethylase 3A 2.1593
MORF4L2 mortality factor 4 like 2 2.15425
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.15295
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.15295
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 2.1501
CNIH1 cornichon family AMPA receptor auxiliary protein 1 2.14805
CHIC2 cysteine-rich hydrophobic domain 2 2.1474
SCG5 secretogranin V 2.1423
RB1CC1 RB1-inducible coiled-coil 1 2.14217
TP53 tumor protein p53 2.1353
ATG14 autophagy related 14 2.132
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.1296
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.1295
STARD13 StAR-related lipid transfer (START) domain containing 13 2.1223
JMJD1C jumonji domain containing 1C 2.12085
RPL39L ribosomal protein L39-like 2.12085
ALAS1 5'-aminolevulinate synthase 1 2.1205
LIN37 lin-37 DREAM MuvB core complex component 2.12045
TRIM9 tripartite motif containing 9 2.1095
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.10775
RNF220 ring finger protein 220 2.10415
KYAT3 kynurenine aminotransferase 3 2.1031
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.10278
ZDHHC7 zinc finger, DHHC-type containing 7 2.10235
LOC122526780 uncharacterized LOC122526780 2.09845
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.09773
IL37 interleukin 37 2.0976
PCSK2 proprotein convertase subtilisin/kexin type 2 2.0961
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.09305
ZFAND5 zinc finger, AN1-type domain 5 2.0863
ADORA2B adenosine A2b receptor 2.0723
ASCC3 activating signal cointegrator 1 complex subunit 3 2.07125
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.0711
YIPF3 Yip1 domain family, member 3 2.06935
ATG2B autophagy related 2B 2.06825
DVL1 dishevelled segment polarity protein 1 2.06765
RBFA ribosome binding factor A (putative) 2.06315
SCPEP1 serine carboxypeptidase 1 2.0614
ARID4B AT rich interactive domain 4B (RBP1-like) 2.061
ARMCX5 armadillo repeat containing, X-linked 5 2.05935
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.05165
ECD ecdysoneless homolog (Drosophila) 2.04895
NPC1 Niemann-Pick disease, type C1 2.04675
EMC7 ER membrane protein complex subunit 7 2.04615
BANP BTG3 associated nuclear protein 2.0455
ZNF571 zinc finger protein 571 2.04385
CALCOCO2 calcium binding and coiled-coil domain 2 2.04275
H2AC6 H2A clustered histone 6 2.03935
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.03845
TFG TRK-fused gene 2.031
ITPKC inositol-trisphosphate 3-kinase C 2.02995
SAR1B secretion associated, Ras related GTPase 1B 2.0298
NPTXR neuronal pentraxin receptor 2.0285
NOP10 NOP10 ribonucleoprotein 2.02785
SLC41A3 solute carrier family 41, member 3 2.0216
MEX3C mex-3 RNA binding family member C 2.02155
F2R coagulation factor II (thrombin) receptor 2.0182
TMEM59 transmembrane protein 59 2.0159
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.0135
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.0129
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.0039
MMRN2 multimerin 2 2.00295

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -10.0
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -9.92325
MELK maternal embryonic leucine zipper kinase -9.85495
TCTN1 tectonic family member 1 -9.71975
STMN1 stathmin 1 -8.5731
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -8.3726
CDC25B cell division cycle 25B -8.04815
AURKB aurora kinase B -7.96215
CDC20 cell division cycle 20 -7.6871
PSRC1 proline/serine-rich coiled-coil 1 -7.2752
B4GAT1 beta-1,4-glucuronyltransferase 1 -6.93385
POLR1A polymerase (RNA) I polypeptide A, 194kDa -6.58565
NUP85 nucleoporin 85kDa -6.4721
TOP2A topoisomerase (DNA) II alpha 170kDa -6.25543
CDK1 cyclin-dependent kinase 1 -6.17327
FGFR4 fibroblast growth factor receptor 4 -6.10635
BIRC5 baculoviral IAP repeat containing 5 -6.04257
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.87735
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.76765
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.75785
LOC124907782 dual specificity protein phosphatase 22 -5.60145
CCNA2 cyclin A2 -5.53902
DDB2 damage-specific DNA binding protein 2, 48kDa -5.5262
NT5DC2 5'-nucleotidase domain containing 2 -5.44855
PLK1 polo-like kinase 1 -5.43245
LDHD lactate dehydrogenase D -5.3801
HADH hydroxyacyl-CoA dehydrogenase -5.11605
HAT1 histone acetyltransferase 1 -5.10785
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
AMDHD2 amidohydrolase domain containing 2 -4.9391
ASF1B anti-silencing function 1B histone chaperone -4.8298
TK1 thymidine kinase 1, soluble -4.75845
CDC45 cell division cycle 45 -4.5905
SOAT2 sterol O-acyltransferase 2 -4.42298
RFC2 replication factor C (activator 1) 2, 40kDa -4.4012
MAP7 microtubule-associated protein 7 -4.3961
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -4.37585
BPHL biphenyl hydrolase-like (serine hydrolase) -4.36055
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -4.31475
MRPS2 mitochondrial ribosomal protein S2 -4.31385
PGAM4 phosphoglycerate mutase family member 4 -4.2869
CPNE3 copine III -4.19203
PGM1 phosphoglucomutase 1 -4.18605
TMEM106C transmembrane protein 106C -4.1684
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -4.153
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -4.10507
KIF11 kinesin family member 11 -4.04725
MSH6 mutS homolog 6 -4.04092
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -4.03345
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -4.01825
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.9757
ISOC1 isochorismatase domain containing 1 -3.9561
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.9401
TRIP13 thyroid hormone receptor interactor 13 -3.9346
THAP11 THAP domain containing 11 -3.93245
CDC6 cell division cycle 6 -3.90947
DSCC1 DNA replication and sister chromatid cohesion 1 -3.90425
NCAPD2 non-SMC condensin I complex, subunit D2 -3.79635
RFC5 replication factor C (activator 1) 5, 36.5kDa -3.7275
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.70035
CDC25A cell division cycle 25A -3.69885
FANCI Fanconi anemia, complementation group I -3.67945
TFDP1 transcription factor Dp-1 -3.6711
HMOX1 heme oxygenase 1 -3.65715
NCAPH non-SMC condensin I complex, subunit H -3.6454
PXMP2 peroxisomal membrane protein 2, 22kDa -3.55795
CENPX centromere protein X -3.5466
MCM10 minichromosome maintenance complex component 10 -3.50895
COG4 component of oligomeric golgi complex 4 -3.49955
ZNF274 zinc finger protein 274 -3.49585
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.49207
ALDOC aldolase C, fructose-bisphosphate -3.4832
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.4727
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.40615
TEDC2 tubulin epsilon and delta complex 2 -3.40435
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.38545
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.38095
LBR lamin B receptor -3.35805
TBC1D10C TBC1 domain family, member 10C -3.3535
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.34685
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -3.3213
PARP1 poly (ADP-ribose) polymerase 1 -3.3195
TIMELESS timeless circadian clock -3.30947
RPA3 replication protein A3, 14kDa -3.3081
RFC4 replication factor C (activator 1) 4, 37kDa -3.3062
TERT telomerase reverse transcriptase -3.28915
EXO1 exonuclease 1 -3.2875
ZNF8 zinc finger protein 8 -3.27515
RBM15B RNA binding motif protein 15B -3.2557
FZD7 frizzled class receptor 7 -3.25505
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -3.25245
ADI1 acireductone dioxygenase 1 -3.23735
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -3.2348
CDK2 cyclin-dependent kinase 2 -3.23207
CD320 CD320 molecule -3.221
CHEK2 checkpoint kinase 2 -3.21702
RECQL4 RecQ protein-like 4 -3.21515
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.17772
MIS18A MIS18 kinetochore protein A -3.17685
ZNF215 zinc finger protein 215 -3.1722
SPDEF SAM pointed domain containing ETS transcription factor -3.16842
CISH cytokine inducible SH2-containing protein -3.15055
ADTRP androgen-dependent TFPI-regulating protein -3.1142
HMGA2 high mobility group AT-hook 2 -3.09115
FANCG Fanconi anemia, complementation group G -3.07615
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -3.0697
ECEL1 endothelin converting enzyme-like 1 -3.03865
UNC119 unc-119 homolog (C. elegans) -3.03525
KIF14 kinesin family member 14 -3.00315
ZNF134 zinc finger protein 134 -2.9985
CDK4 cyclin-dependent kinase 4 -2.98405
NLRP2B NLR family pyrin domain containing 2B -2.97075
CCS copper chaperone for superoxide dismutase -2.9533
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.95025
TMEM97 transmembrane protein 97 -2.92585
ECH1 enoyl CoA hydratase 1, peroxisomal -2.9134
TUBB6 tubulin, beta 6 class V -2.9071
RPIA ribose 5-phosphate isomerase A -2.90225
MSH2 mutS homolog 2 -2.8987
ELAC2 elaC ribonuclease Z 2 -2.89235
PROS1 protein S (alpha) -2.8891
NUP107 nucleoporin 107kDa -2.87205
SPAG5 sperm associated antigen 5 -2.87075
CLCN2 chloride channel, voltage-sensitive 2 -2.8585
TMEM109 transmembrane protein 109 -2.85625
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.8509
C2CD5 C2 calcium-dependent domain containing 5 -2.8441
KIFC1 kinesin family member C1 -2.84155
WRAP53 WD repeat containing, antisense to TP53 -2.80918
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.80695
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.79425
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.78885
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.78655
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.784
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.7826
IGFLR1 IGF-like family receptor 1 -2.7815
GLYAT glycine-N-acyltransferase -2.77566
UNG uracil-DNA glycosylase -2.76885
GMNN geminin, DNA replication inhibitor -2.76225
RACGAP1 Rac GTPase activating protein 1 -2.7607
CENPM centromere protein M -2.7508
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.74345
RFC3 replication factor C (activator 1) 3, 38kDa -2.7416
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.7315
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.7248
KHK ketohexokinase (fructokinase) -2.72475
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.72435
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.72215
AURKC aurora kinase C -2.71735
PKLR pyruvate kinase, liver and RBC -2.71147
NNT nicotinamide nucleotide transhydrogenase -2.70905
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.7081
FN3KRP fructosamine 3 kinase related protein -2.70035
CCNB1 cyclin B1 -2.6973
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.69292
NUP37 nucleoporin 37kDa -2.66415
HSPB1 heat shock 27kDa protein 1 -2.66345
ECT2 epithelial cell transforming 2 -2.6559
UBE2C ubiquitin-conjugating enzyme E2C -2.6504
LIME1 Lck interacting transmembrane adaptor 1 -2.64755
FEN1 flap structure-specific endonuclease 1 -2.634
TM9SF3 transmembrane 9 superfamily member 3 -2.62995
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.6274
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.6196
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.6153
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.60885
ACAA1 acetyl-CoA acyltransferase 1 -2.6016
TFF3 trefoil factor 3 (intestinal) -2.5955
NFYB nuclear transcription factor Y, beta -2.58567
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.58285
TMEM14A transmembrane protein 14A -2.5812
ZDHHC6 zinc finger, DHHC-type containing 6 -2.5774
DHFR dihydrofolate reductase -2.57662
FAM111A family with sequence similarity 111, member A -2.57635
CETN2 centrin, EF-hand protein, 2 -2.5717
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.5676
DERA deoxyribose-phosphate aldolase (putative) -2.5534
AURKA aurora kinase A -2.5527
PCNA proliferating cell nuclear antigen -2.54435
FOXM1 forkhead box M1 -2.5426
NUP62 nucleoporin 62kDa -2.53923
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.5179
LAP3 leucine aminopeptidase 3 -2.5072
FNDC11 fibronectin type III domain containing 11 -2.4945
GALT galactose-1-phosphate uridylyltransferase -2.4884
SPC25 SPC25, NDC80 kinetochore complex component -2.4848
GSTM2 glutathione S-transferase mu 2 (muscle) -2.48287
PRUNE1 prune exopolyphosphatase 1 -2.48083
ZWINT ZW10 interacting kinetochore protein -2.4708
PAEP progestagen-associated endometrial protein -2.4681
NENF neudesin neurotrophic factor -2.46408
OCA2 oculocutaneous albinism II -2.45085
TM7SF2 transmembrane 7 superfamily member 2 -2.4495
OIP5 Opa interacting protein 5 -2.4299
POLK polymerase (DNA directed) kappa -2.42835
PRPF31 pre-mRNA processing factor 31 -2.4283
TOR3A torsin family 3, member A -2.4275
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.42505
NDC80 NDC80 kinetochore complex component -2.4237
CENPS-CORT CENPS-CORT readthrough -2.42055
SHARPIN SHANK-associated RH domain interactor -2.41965
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.4137
GPR153 G protein-coupled receptor 153 -2.41208
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.4073
MCM4 minichromosome maintenance complex component 4 -2.40628
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.39245
WNT11 wingless-type MMTV integration site family, member 11 -2.392
EPHB3 EPH receptor B3 -2.3919
KIF4A kinesin family member 4A -2.39015
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.38895
KNTC1 kinetochore associated 1 -2.3883
SOCS1 suppressor of cytokine signaling 1 -2.38215
NEMP1 nuclear envelope integral membrane protein 1 -2.3806
CXCL2 chemokine (C-X-C motif) ligand 2 -2.37975
COQ3 coenzyme Q3 methyltransferase -2.3792
CDT1 chromatin licensing and DNA replication factor 1 -2.3776
ACTL8 actin-like 8 -2.37695
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.37615
TFAM transcription factor A, mitochondrial -2.37377
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.37025
CCNE1 cyclin E1 -2.3701
GUCA1B guanylate cyclase activator 1B (retina) -2.3658
MYBPC3 myosin binding protein C, cardiac -2.3628
CCDC9 coiled-coil domain containing 9 -2.35145
HOXC8 homeobox C8 -2.34835
IFT81 intraflagellar transport 81 -2.3461
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.344
TREML2 triggering receptor expressed on myeloid cells-like 2 -2.34115
HGH1 HGH1 homolog (S. cerevisiae) -2.34075
ZNF273 zinc finger protein 273 -2.33365
PECR peroxisomal trans-2-enoyl-CoA reductase -2.33275
MCMBP minichromosome maintenance complex binding protein -2.33235
SCCPDH saccharopine dehydrogenase (putative) -2.32682
CNTFR ciliary neurotrophic factor receptor -2.32255
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.32025
UBAC1 UBA domain containing 1 -2.3183
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.3178
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.314
TMPRSS5 transmembrane protease, serine 5 -2.31125
MAPK9 mitogen-activated protein kinase 9 -2.31033
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.3091
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.30885
TATDN2 TatD DNase domain containing 2 -2.3086
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -2.30785
MYCBP MYC binding protein -2.30608
ZNF84 zinc finger protein 84 -2.30365
TROAP trophinin associated protein -2.30305
CCND3 cyclin D3 -2.2997
PRKD3 protein kinase D3 -2.29535
DEPDC1 DEP domain containing 1 -2.2923
WDR62 WD repeat domain 62 -2.28735
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.2855
ARF5 ADP-ribosylation factor 5 -2.2844
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.28325
KIF15 kinesin family member 15 -2.28235
IL25 interleukin 25 -2.27835
CTSV cathepsin V -2.27305
CCP110 centriolar coiled coil protein 110kDa -2.2717
NCAPG2 non-SMC condensin II complex, subunit G2 -2.2653
ZNF446 zinc finger protein 446 -2.2646
TNK1 tyrosine kinase, non-receptor, 1 -2.2643
PRR5 proline rich 5 (renal) -2.26153
SLC2A4RG SLC2A4 regulator -2.2607
KREMEN2 kringle containing transmembrane protein 2 -2.25915
CCDC86 coiled-coil domain containing 86 -2.2581
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.25565
HMGB3 high mobility group box 3 -2.24775
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.24375
EXOSC9 exosome component 9 -2.23855
SDC2 syndecan 2 -2.23658
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.234
HOXC5 homeobox C5 -2.23255
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.22835
VRK1 vaccinia related kinase 1 -2.22825
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.22595
CCDC106 coiled-coil domain containing 106 -2.22405
GALK1 galactokinase 1 -2.21905
CEP72 centrosomal protein 72kDa -2.2155
MCM3 minichromosome maintenance complex component 3 -2.2145
CCDC15 coiled-coil domain containing 15 -2.2143
RORC RAR-related orphan receptor C -2.21405
QTRT1 queuine tRNA-ribosyltransferase 1 -2.2123
FANCA Fanconi anemia, complementation group A -2.20688
KLHDC2 kelch domain containing 2 -2.20565
PFKL phosphofructokinase, liver -2.20472
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.20225
ADRA2B adrenoceptor alpha 2B -2.20115
DIPK2B divergent protein kinase domain 2B -2.19905
PRDM12 PR domain containing 12 -2.1987
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 -2.198
OBP2A odorant binding protein 2A -2.1978
TMSB15C thymosin beta 15C -2.1921
ITGB7 integrin, beta 7 -2.18585
SLC66A3 solute carrier family 66 member 3 -2.18555
RAD54L RAD54-like (S. cerevisiae) -2.18
CAV3 caveolin 3 -2.17985
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.17885
CDCA8 cell division cycle associated 8 -2.17515
TTC12 tetratricopeptide repeat domain 12 -2.1725
PIMREG PICALM interacting mitotic regulator -2.17095
ZBTB24 zinc finger and BTB domain containing 24 -2.1683
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.16175
MSH5 mutS homolog 5 -2.1617
CALCA calcitonin-related polypeptide alpha -2.16089
TMEM143 transmembrane protein 143 -2.15825
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.1581
NRTN neurturin -2.1567
NEK11 NIMA-related kinase 11 -2.15495
CEP131 centrosomal protein 131kDa -2.1535
CDX1 caudal type homeobox 1 -2.1513
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.1496
ATAD2 ATPase family, AAA domain containing 2 -2.1461
HLA-DOB major histocompatibility complex, class II, DO beta -2.14355
DHRS4 dehydrogenase/reductase (SDR family) member 4 -2.1413
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.1397
MRPS7 mitochondrial ribosomal protein S7 -2.1386
ZWILCH zwilch kinetochore protein -2.1385
ICMT isoprenylcysteine carboxyl methyltransferase -2.13617
MRPL12 mitochondrial ribosomal protein L12 -2.136
HLA-DOA major histocompatibility complex, class II, DO alpha -2.12485
GPS1 G protein pathway suppressor 1 -2.1206
CIB2 calcium and integrin binding family member 2 -2.11998
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.1184
SNTA1 syntrophin, alpha 1 -2.1178
SPDL1 spindle apparatus coiled-coil protein 1 -2.1161
EDA2R ectodysplasin A2 receptor -2.11255
GPR21 G protein-coupled receptor 21 -2.10905
HYDIN HYDIN, axonemal central pair apparatus protein -2.10485
ATAD3A ATPase family, AAA domain containing 3A -2.10475
ZNF606 zinc finger protein 606 -2.10435
RMI1 RecQ mediated genome instability 1 -2.10375
DAO D-amino-acid oxidase -2.1017
HMGN3 high mobility group nucleosomal binding domain 3 -2.10025
FBXO5 F-box protein 5 -2.0957
CCDC85B coiled-coil domain containing 85B -2.0904
MRM2 mitochondrial rRNA methyltransferase 2 -2.09002
APEH acylaminoacyl-peptide hydrolase -2.0887
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.08825
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.08725
CCNB2 cyclin B2 -2.087
KLK2 kallikrein-related peptidase 2 -2.08593
MKI67 marker of proliferation Ki-67 -2.08435
PCDHA10 protocadherin alpha 10 -2.084
E2F1 E2F transcription factor 1 -2.08285
S100A4 S100 calcium binding protein A4 -2.0813
PCDHB13 protocadherin beta 13 -2.07935
MCM5 minichromosome maintenance complex component 5 -2.07698
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.0741
TMPRSS6 transmembrane protease, serine 6 -2.0725
AGMAT agmatine ureohydrolase (agmatinase) -2.07195
PLCD1 phospholipase C, delta 1 -2.07135
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.0698
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 -2.0678
GBX1 gastrulation brain homeobox 1 -2.0664
DBF4 DBF4 zinc finger -2.0656
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.065
TTC38 tetratricopeptide repeat domain 38 -2.06485
DEK DEK proto-oncogene -2.06125
NCAPH2 non-SMC condensin II complex, subunit H2 -2.05902
EXOC2 exocyst complex component 2 -2.0587
KLK14 kallikrein-related peptidase 14 -2.05785
ATAD5 ATPase family, AAA domain containing 5 -2.0569
SPEF1 sperm flagellar 1 -2.04965
LAGE3 L antigen family, member 3 -2.04965
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.0474
TSNAXIP1 translin-associated factor X interacting protein 1 -2.0472
MRPL16 mitochondrial ribosomal protein L16 -2.0472
ANGPT4 angiopoietin 4 -2.04605
ERCC6L excision repair cross-complementation group 6-like -2.04525
USP22 ubiquitin specific peptidase 22 -2.04355
ECI2 enoyl-CoA delta isomerase 2 -2.0425
CCNP cyclin P -2.04245
HDAC11 histone deacetylase 11 -2.0421
ADM2 adrenomedullin 2 -2.0417
FBXL6 F-box and leucine-rich repeat protein 6 -2.0357
DCPH1 damage control phosphatase 1 -2.03215
SH3GL3 SH3-domain GRB2-like 3 -2.03135
KLF15 Kruppel-like factor 15 -2.03
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.02695
S100A1 S100 calcium binding protein A1 -2.0269
NKX2-5 NK2 homeobox 5 -2.0221
HAUS7 HAUS augmin-like complex, subunit 7 -2.02023
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.01945
PPIF peptidylprolyl isomerase F -2.01938
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.01934
BAX BCL2-associated X protein -2.01148
ACAA2 acetyl-CoA acyltransferase 2 -2.01145
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 -2.0096
ZNF671 zinc finger protein 671 -2.0095
SOSTDC1 sclerostin domain containing 1 -2.00525
NEK2 NIMA-related kinase 2 -2.00515
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.00125