CRCGN012_HEPG2_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 9.98 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

132 genes differentially expressed following the CRCGN012_HEPG2_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
UBQLN2 ubiquilin 2 6.91094
NUCB2 nucleobindin 2 6.43127
KCNK1 potassium channel, two pore domain subfamily K, member 1 5.69765
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.8819
TIMP2 TIMP metallopeptidase inhibitor 2 4.33617
CGRRF1 cell growth regulator with ring finger domain 1 4.08341
TRIB3 tribbles pseudokinase 3 4.08182
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 4.0423
ADGRE5 adhesion G protein-coupled receptor E5 3.71144
CHN1 chimerin 1 3.70037
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.58178
RRAGA Ras-related GTP binding A 3.56193
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.46796
GSTZ1 glutathione S-transferase zeta 1 3.43937
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.39187
SNAP25 synaptosomal-associated protein, 25kDa 3.38858
MBNL2 muscleblind-like splicing regulator 2 3.36141
INPP1 inositol polyphosphate-1-phosphatase 3.30178
MAMLD1 mastermind-like domain containing 1 3.13258
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.06925
SLC35B1 solute carrier family 35, member B1 2.93466
PHGDH phosphoglycerate dehydrogenase 2.89655
ZW10 zw10 kinetochore protein 2.86451
LYN LYN proto-oncogene, Src family tyrosine kinase 2.86312
TM9SF2 transmembrane 9 superfamily member 2 2.8323
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.78471
CYCS cytochrome c, somatic 2.76741
AXIN1 axin 1 2.76004
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.73965
CCP110 centriolar coiled coil protein 110kDa 2.68741
CXCL2 chemokine (C-X-C motif) ligand 2 2.61801
ABHD4 abhydrolase domain containing 4 2.61386
CCNH cyclin H 2.57361
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.57304
CCL2 chemokine (C-C motif) ligand 2 2.54539
GARS1 glycyl-tRNA synthetase 1 2.52313
DIPK1A divergent protein kinase domain 1A 2.52281
SARS1 seryl-tRNA synthetase 1 2.51883
CCNA1 cyclin A1 2.50872
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.4882
TXNRD1 thioredoxin reductase 1 2.45079
EPHA3 EPH receptor A3 2.43672
TERF2IP telomeric repeat binding factor 2, interacting protein 2.42894
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.38779
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.38095
DDIT4 DNA-damage-inducible transcript 4 2.3502
TRAK2 trafficking protein, kinesin binding 2 2.3387
LCN2 lipocalin 2 2.28945
UFM1 ubiquitin-fold modifier 1 2.27874
TUBB6 tubulin, beta 6 class V 2.25741
NPDC1 neural proliferation, differentiation and control, 1 2.24989
GLRX glutaredoxin (thioltransferase) 2.21311
COPG1 coatomer protein complex, subunit gamma 1 2.2086
ARFIP2 ADP-ribosylation factor interacting protein 2 2.19966
KIF5C kinesin family member 5C 2.18958
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.17834
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.17721
TSPYL4 TSPY-like 4 2.1765
EVL Enah/Vasp-like 2.13714
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.10671
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.10221
LOC128125814 uncharacterized LOC128125814 2.09883
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.09118
EGR1 early growth response 1 2.07653
VWA1 von Willebrand factor A domain containing 1 2.07508
R3HCC1L R3H domain and coiled-coil containing 1-like 2.07478
TRIB1 tribbles pseudokinase 1 2.07309
AARS1 alanyl-tRNA synthetase 1 2.07148
RFXAP regulatory factor X-associated protein 2.06583
FAM8A1 family with sequence similarity 8, member A1 2.06569
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.05991
VGLL4 vestigial-like family member 4 2.05222
ITCH itchy E3 ubiquitin protein ligase 2.04697
DUSP6 dual specificity phosphatase 6 2.04661
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.04415
RNF103 ring finger protein 103 2.01999
YOD1 YOD1 deubiquitinase 2.01766
JADE2 jade family PHD finger 2 2.00566

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -6.67924
CDC25B cell division cycle 25B -6.26072
DSG2 desmoglein 2 -6.23109
CDC20 cell division cycle 20 -5.74143
CCNB1 cyclin B1 -5.67364
PCNA proliferating cell nuclear antigen -5.57888
ISOC1 isochorismatase domain containing 1 -4.54368
AURKB aurora kinase B -4.4079
PSRC1 proline/serine-rich coiled-coil 1 -4.34546
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.29157
DERA deoxyribose-phosphate aldolase (putative) -4.18629
ZDHHC6 zinc finger, DHHC-type containing 6 -4.0092
CDK1 cyclin-dependent kinase 1 -4.00158
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.98463
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.84993
PLK1 polo-like kinase 1 -3.66243
MELK maternal embryonic leucine zipper kinase -3.61965
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.55305
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.4548
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.26143
LBR lamin B receptor -3.11153
HAT1 histone acetyltransferase 1 -3.10174
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.05191
TOP2A topoisomerase (DNA) II alpha 170kDa -3.02837
LDHD lactate dehydrogenase D -2.96056
STMN1 stathmin 1 -2.86601
S100A4 S100 calcium binding protein A4 -2.8587
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.81463
ICAM3 intercellular adhesion molecule 3 -2.75086
CCNA2 cyclin A2 -2.69243
CCNB2 cyclin B2 -2.64195
FBXL12 F-box and leucine-rich repeat protein 12 -2.62547
CHMP4B charged multivesicular body protein 4B -2.62369
BIRC5 baculoviral IAP repeat containing 5 -2.52271
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.47477
AMDHD2 amidohydrolase domain containing 2 -2.44901
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.35848
PPOX protoporphyrinogen oxidase -2.28211
NFIL3 nuclear factor, interleukin 3 regulated -2.27308
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.2647
RBM15B RNA binding motif protein 15B -2.25622
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.24953
PCCB propionyl CoA carboxylase, beta polypeptide -2.23516
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.17655
CLEC10A C-type lectin domain family 10, member A -2.16559
SMC4 structural maintenance of chromosomes 4 -2.13241
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.12798
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.108
DCLRE1A DNA cross-link repair 1A -2.03903
TCERG1 transcription elongation regulator 1 -2.0355
NUP37 nucleoporin 37kDa -2.03505
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.03294
MSH2 mutS homolog 2 -2.02407