CRCGN012_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 4.99 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN012_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 6.88594
GSTZ1 glutathione S-transferase zeta 1 5.82111
CCL2 chemokine (C-C motif) ligand 2 5.75721
NUCB2 nucleobindin 2 5.53965
CHN1 chimerin 1 4.55454
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 4.05834
EVL Enah/Vasp-like 3.85898
TIAM1 T-cell lymphoma invasion and metastasis 1 3.63402
UBQLN2 ubiquilin 2 3.55219
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.47815
RRAGA Ras-related GTP binding A 3.46369
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.44536
PPARG peroxisome proliferator-activated receptor gamma 3.40089
TRIB3 tribbles pseudokinase 3 3.30286
CSK c-src tyrosine kinase 3.20618
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.20476
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.16088
LCN2 lipocalin 2 3.14359
PRKCH protein kinase C, eta 3.12637
DYNLT3 dynein, light chain, Tctex-type 3 3.11634
INPP1 inositol polyphosphate-1-phosphatase 3.07159
UGDH UDP-glucose 6-dehydrogenase 3.06316
MEF2C myocyte enhancer factor 2C 2.98137
PRR15L proline rich 15-like 2.92944
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.92695
ABHD6 abhydrolase domain containing 6 2.88104
CDC45 cell division cycle 45 2.87588
CCP110 centriolar coiled coil protein 110kDa 2.85057
PNKP polynucleotide kinase 3'-phosphatase 2.84997
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.75236
HOXA10 homeobox A10 2.69179
SNAP25 synaptosomal-associated protein, 25kDa 2.64543
CHMP6 charged multivesicular body protein 6 2.6088
UFM1 ubiquitin-fold modifier 1 2.6082
AHR aryl hydrocarbon receptor 2.5042
NOSIP nitric oxide synthase interacting protein 2.50261
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.48385
ZW10 zw10 kinetochore protein 2.45886
HYOU1 hypoxia up-regulated 1 2.36023
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.32065
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.30027
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.28468
ARFIP2 ADP-ribosylation factor interacting protein 2 2.28268
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.22302
CDPF1 cysteine-rich, DPF motif domain containing 1 2.17307
CYCS cytochrome c, somatic 2.16337
CSF1R colony stimulating factor 1 receptor 2.12503
SFTPB surfactant protein B 2.12266
LOC122526780 uncharacterized LOC122526780 2.1002
SLC35B1 solute carrier family 35, member B1 2.09336
ICAM1 intercellular adhesion molecule 1 2.08371
EGR1 early growth response 1 2.03838
WDR7 WD repeat domain 7 2.02109
TM9SF2 transmembrane 9 superfamily member 2 2.01257

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.14165
DSG2 desmoglein 2 -6.12151
CDC25B cell division cycle 25B -5.73657
CCNB2 cyclin B2 -5.50363
WASHC4 WASH complex subunit 4 -4.91453
THAP11 THAP domain containing 11 -4.70428
ZDHHC6 zinc finger, DHHC-type containing 6 -4.69314
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.08134
SOAT2 sterol O-acyltransferase 2 -4.01615
PCCB propionyl CoA carboxylase, beta polypeptide -3.95965
EGF epidermal growth factor -3.94105
LDHD lactate dehydrogenase D -3.70236
ZNF586 zinc finger protein 586 -3.64034
CCNB1 cyclin B1 -3.33722
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.30136
AURKB aurora kinase B -3.26481
PCNA proliferating cell nuclear antigen -3.2502
OXA1L oxidase (cytochrome c) assembly 1-like -3.17273
TLCD3A TLC domain containing 3A -3.00353
LOC124907782 dual specificity protein phosphatase 22 -2.9905
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.96752
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.9343
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.91414
MELK maternal embryonic leucine zipper kinase -2.84275
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.83382
FBXL12 F-box and leucine-rich repeat protein 12 -2.62084
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.59516
DNM1L dynamin 1-like -2.57876
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.5532
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.50122
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.48725
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.21683
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.21192
EIF5 eukaryotic translation initiation factor 5 -2.16595
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.16022
NGRN neugrin, neurite outgrowth associated -2.13109
S100A4 S100 calcium binding protein A4 -2.08548
RBM15B RNA binding motif protein 15B -2.08141
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.07466
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.04413
NUP37 nucleoporin 37kDa -2.01844