CRCGN012_HEPG2_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN012_HEPG2_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.0923
NUCB2 nucleobindin 2 6.29793
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.09345
CCL2 chemokine (C-C motif) ligand 2 5.20941
ATP11B ATPase, class VI, type 11B 3.9161
CIAO3 cytosolic iron-sulfur assembly component 3 3.74168
UBQLN2 ubiquilin 2 3.52381
RPL39L ribosomal protein L39-like 3.38062
LCN2 lipocalin 2 3.29856
E2F2 E2F transcription factor 2 3.21086
DYNLT3 dynein, light chain, Tctex-type 3 3.20607
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.19829
NOTCH1 notch 1 3.18008
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.06207
MEF2C myocyte enhancer factor 2C 3.00121
UGDH UDP-glucose 6-dehydrogenase 2.95894
H2BC12 H2B clustered histone 12 2.83523
SNAP25 synaptosomal-associated protein, 25kDa 2.79779
TRIB3 tribbles pseudokinase 3 2.75453
HYOU1 hypoxia up-regulated 1 2.60106
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.54596
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.48278
GSTZ1 glutathione S-transferase zeta 1 2.48183
CCP110 centriolar coiled coil protein 110kDa 2.47972
MYLK myosin light chain kinase 2.45243
LPAR2 lysophosphatidic acid receptor 2 2.41012
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.30291
CDC45 cell division cycle 45 2.30051
SARS1 seryl-tRNA synthetase 1 2.29215
CDPF1 cysteine-rich, DPF motif domain containing 1 2.27348
NPDC1 neural proliferation, differentiation and control, 1 2.25615
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.23543
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.23215
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.22784
UFM1 ubiquitin-fold modifier 1 2.21679
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.20405
EPN2 epsin 2 2.18799
ABHD4 abhydrolase domain containing 4 2.07696
BAD BCL2-associated agonist of cell death 2.05566
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.01502

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.73144
MAP7 microtubule-associated protein 7 -4.52148
ZDHHC6 zinc finger, DHHC-type containing 6 -3.5322
KDM3A lysine (K)-specific demethylase 3A -3.47547
ADI1 acireductone dioxygenase 1 -3.06453
EIF5 eukaryotic translation initiation factor 5 -3.00072
ITGB1BP1 integrin beta 1 binding protein 1 -2.86923
MRPS2 mitochondrial ribosomal protein S2 -2.75561
OXA1L oxidase (cytochrome c) assembly 1-like -2.68074
CDC25B cell division cycle 25B -2.63317
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.61854
SLC35F2 solute carrier family 35, member F2 -2.57765
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.45082
HAT1 histone acetyltransferase 1 -2.35427
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.31224
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.26089
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.22136
CCNB2 cyclin B2 -2.21009
GNAS GNAS complex locus -2.20361
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.18702
PLK1 polo-like kinase 1 -2.1771
MACF1 microtubule-actin crosslinking factor 1 -2.13831
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.11184
ICAM3 intercellular adhesion molecule 3 -2.0632
RNF167 ring finger protein 167 -2.04648
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.00137