CRCGN012_HEPG2_24H:J01 Gene Set
Dataset
Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category
transcriptomics
Type
small molecule perturbation
Description
trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 20.58 um perturbation at 24 h in HEPG2 (Carcinogenome )
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Genes
31 genes differentially expressed following the CRCGN012_HEPG2_24H:J01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
Symbol
Name
Standardized Value
NOTCH1
notch 1
7.25437
NOSIP
nitric oxide synthase interacting protein
4.4504
LYN
LYN proto-oncogene, Src family tyrosine kinase
4.18049
CSK
c-src tyrosine kinase
4.10078
CIAO3
cytosolic iron-sulfur assembly component 3
3.19958
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
3.10692
CHAC1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
2.93352
PRKCH
protein kinase C, eta
2.7093
ICAM1
intercellular adhesion molecule 1
2.70417
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
2.65525
CGRRF1
cell growth regulator with ring finger domain 1
2.47774
AXIN1
axin 1
2.39954
EPHA3
EPH receptor A3
2.21062
NR1H2
nuclear receptor subfamily 1, group H, member 2
2.1737
CREG1
cellular repressor of E1A-stimulated genes 1
2.09346
NMU
neuromedin U
2.06133
PTK2
protein tyrosine kinase 2
2.0294
decreased expression
Symbol
Name
Standardized Value
LDHD
lactate dehydrogenase D
-6.80759
NT5DC2
5'-nucleotidase domain containing 2
-4.81034
LOC124907782
dual specificity protein phosphatase 22
-4.55757
TARBP1
TAR (HIV-1) RNA binding protein 1
-4.48795
DERA
deoxyribose-phosphate aldolase (putative)
-4.43848
CDC25B
cell division cycle 25B
-4.156
VAT1
vesicle amine transport 1
-3.24247
ERC2
ELKS/RAB6-interacting/CAST family member 2
-3.01667
PECR
peroxisomal trans-2-enoyl-CoA reductase
-2.65094
NGRN
neugrin, neurite outgrowth associated
-2.55927
VDAC1
voltage-dependent anion channel 1
-2.36585
CCNB2
cyclin B2
-2.18257
ITGB1BP1
integrin beta 1 binding protein 1
-2.10604
HLA-DMA
major histocompatibility complex, class II, DM alpha
-2.10351
