CRCGN012_HEPG2_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 10.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN012_HEPG2_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.74721
DYNLT3 dynein, light chain, Tctex-type 3 5.7272
STIMATE STIM activating enhancer 5.45653
ADRB2 adrenoceptor beta 2, surface 5.45622
TIAM1 T-cell lymphoma invasion and metastasis 1 4.65302
CYCS cytochrome c, somatic 4.31514
RPP38 ribonuclease P/MRP 38kDa subunit 4.09503
MOK MOK protein kinase 3.9121
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.71098
LCN2 lipocalin 2 3.68126
CBR3 carbonyl reductase 3 3.54152
EPHA3 EPH receptor A3 3.48787
CSK c-src tyrosine kinase 3.45132
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.27607
CGRRF1 cell growth regulator with ring finger domain 1 3.12973
EAPP E2F-associated phosphoprotein 3.11111
HOXA10 homeobox A10 2.94319
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.85407
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.68915
MYLK myosin light chain kinase 2.4837
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.34222
STXBP2 syntaxin binding protein 2 2.1315
SLC75A1 solute carrier family 75 member 1 2.08576
REEP4 receptor accessory protein 4 2.07314
DIPK1A divergent protein kinase domain 1A 2.03161

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.60532
TRAP1 TNF receptor-associated protein 1 -5.91163
ADI1 acireductone dioxygenase 1 -5.79739
TP53BP2 tumor protein p53 binding protein 2 -4.26446
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.21059
C2CD5 C2 calcium-dependent domain containing 5 -4.07444
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.58553
NGRN neugrin, neurite outgrowth associated -3.26741
SNX11 sorting nexin 11 -3.1466
MAPK13 mitogen-activated protein kinase 13 -3.10703
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.55385
FGFR4 fibroblast growth factor receptor 4 -2.51267
TWNK twinkle mtDNA helicase -2.29803
PRPF4 pre-mRNA processing factor 4 -2.15916
PCNA proliferating cell nuclear antigen -2.13502
IPO13 importin 13 -2.07784
FXYD2 FXYD domain containing ion transport regulator 2 -2.07184
WASHC4 WASH complex subunit 4 -2.00518