| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 5.15 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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86 genes differentially expressed following the CRCGN012_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSK | c-src tyrosine kinase | 9.65553 |
| NOTCH1 | notch 1 | 8.33339 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 8.26754 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 6.40773 |
| GSTZ1 | glutathione S-transferase zeta 1 | 5.8019 |
| LCN2 | lipocalin 2 | 5.36157 |
| ANO10 | anoctamin 10 | 5.25568 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.22105 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 5.11151 |
| EPHB2 | EPH receptor B2 | 5.04529 |
| E2F2 | E2F transcription factor 2 | 4.97392 |
| ADRB2 | adrenoceptor beta 2, surface | 4.88558 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.88291 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.66809 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.45392 |
| CYCS | cytochrome c, somatic | 3.82859 |
| NOSIP | nitric oxide synthase interacting protein | 3.82672 |
| HOXA10 | homeobox A10 | 3.67445 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.65596 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.52776 |
| GPATCH8 | G patch domain containing 8 | 3.5169 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 3.14062 |
| FZD7 | frizzled class receptor 7 | 3.08999 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 2.96209 |
| CHN1 | chimerin 1 | 2.95415 |
| MOK | MOK protein kinase | 2.8719 |
| HSPA1A | heat shock 70kDa protein 1A | 2.8279 |
| GATA3 | GATA binding protein 3 | 2.75713 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.68887 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.45899 |
| SASH3 | SAM and SH3 domain containing 3 | 2.32953 |
| PMM2 | phosphomannomutase 2 | 2.32764 |
| ADAM10 | ADAM metallopeptidase domain 10 | 2.30166 |
| TLR4 | toll-like receptor 4 | 2.30042 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 2.27254 |
| STXBP2 | syntaxin binding protein 2 | 2.2675 |
| PCDHB11 | protocadherin beta 11 | 2.26089 |
| LY86 | lymphocyte antigen 86 | 2.22319 |
| SMIM40 | small integral membrane protein 40 | 2.20133 |
| BTG2 | BTG family, member 2 | 2.1772 |
| DNMBP | dynamin binding protein | 2.16782 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | 2.16143 |
| ZNF146 | zinc finger protein 146 | 2.10396 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 2.09942 |
| SIX1 | SIX homeobox 1 | 2.04463 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 2.01844 |
| PTK2 | protein tyrosine kinase 2 | 2.00853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.38425 |
| SLC35F2 | solute carrier family 35, member F2 | -5.03659 |
| PCNA | proliferating cell nuclear antigen | -3.89252 |
| CTSD | cathepsin D | -3.87067 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -3.45475 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.26265 |
| SPDEF | SAM pointed domain containing ETS transcription factor | -3.0802 |
| RAI14 | retinoic acid induced 14 | -2.79075 |
| FBXO41 | F-box protein 41 | -2.78274 |
| GLOD4 | glyoxalase domain containing 4 | -2.67084 |
| TIMELESS | timeless circadian clock | -2.66731 |
| PDS5A | PDS5 cohesin associated factor A | -2.59835 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.53862 |
| SPAG4 | sperm associated antigen 4 | -2.5269 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -2.51655 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.43382 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.418 |
| SCAND1 | SCAN domain containing 1 | -2.38065 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.33976 |
| ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | -2.33858 |
| SNAP29 | synaptosomal-associated protein, 29kDa | -2.32473 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -2.27777 |
| GTPBP8 | GTP-binding protein 8 (putative) | -2.27536 |
| TENT2 | terminal nucleotidyltransferase 2 | -2.23401 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.19806 |
| TM4SF4 | transmembrane 4 L six family member 4 | -2.19466 |
| RPS26 | ribosomal protein S26 | -2.17976 |
| NPTX1 | neuronal pentraxin I | -2.13846 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -2.11701 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | -2.11684 |
| ZNF500 | zinc finger protein 500 | -2.11166 |
| LZTR1 | leucine-zipper-like transcription regulator 1 | -2.10831 |
| CCNB1 | cyclin B1 | -2.09635 |
| GRB7 | growth factor receptor-bound protein 7 | -2.09527 |
| CDIP1 | cell death-inducing p53 target 1 | -2.07747 |
| CCL3L3 | chemokine (C-C motif) ligand 3-like 3 | -2.05721 |
| GBA1 | glucosylceramidase beta 1 | -2.05606 |
| GNAS | GNAS complex locus | -2.03597 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.02165 |
