| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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51 genes differentially expressed following the CRCGN012_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.42395 |
| CHN1 | chimerin 1 | 4.36073 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.08672 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.90519 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.84169 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.74881 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 3.65014 |
| CRTAP | cartilage associated protein | 3.56096 |
| MCOLN1 | mucolipin 1 | 3.52973 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 3.50279 |
| ATP11B | ATPase, class VI, type 11B | 3.46998 |
| LCN2 | lipocalin 2 | 3.24654 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.08086 |
| STK10 | serine/threonine kinase 10 | 2.87618 |
| E2F2 | E2F transcription factor 2 | 2.81921 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.77762 |
| HOXA10 | homeobox A10 | 2.76831 |
| NOSIP | nitric oxide synthase interacting protein | 2.67701 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.63637 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.56415 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 2.43003 |
| CSK | c-src tyrosine kinase | 2.39204 |
| MYLK | myosin light chain kinase | 2.28086 |
| COL9A1 | collagen, type IX, alpha 1 | 2.26007 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.20731 |
| S100A2 | S100 calcium binding protein A2 | 2.05737 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 2.0552 |
| VAX2 | ventral anterior homeobox 2 | 2.0204 |
| KIF14 | kinesin family member 14 | 2.00253 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -7.36048 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.42202 |
| KDM3A | lysine (K)-specific demethylase 3A | -6.34175 |
| CD320 | CD320 molecule | -4.0609 |
| THAP11 | THAP domain containing 11 | -4.00364 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.98405 |
| LDHD | lactate dehydrogenase D | -3.51513 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.3546 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.34887 |
| SNX11 | sorting nexin 11 | -3.34687 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.26612 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.095 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.08882 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -3.00949 |
| EGF | epidermal growth factor | -2.90152 |
| MAP7 | microtubule-associated protein 7 | -2.87586 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.85433 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.82746 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.67808 |
| CHMP4B | charged multivesicular body protein 4B | -2.64921 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.48469 |
| CCNB1 | cyclin B1 | -2.35027 |
