CRCGN012_HEPG2_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN012_HEPG2_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.92403
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.85281
ADRB2 adrenoceptor beta 2, surface 5.63074
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.53327
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.14903
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.06881
AMDHD2 amidohydrolase domain containing 2 4.9679
PPARG peroxisome proliferator-activated receptor gamma 4.57195
PRR15L proline rich 15-like 4.57075
CHN1 chimerin 1 4.50965
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.23
MYLK myosin light chain kinase 4.18846
MINDY1 MINDY lysine 48 deubiquitinase 1 3.88388
GSTZ1 glutathione S-transferase zeta 1 3.81496
GPER1 G protein-coupled estrogen receptor 1 3.57127
CSK c-src tyrosine kinase 3.5256
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.42973
DMTF1 cyclin D binding myb-like transcription factor 1 3.22653
VGLL4 vestigial-like family member 4 3.16798
DENND2D DENN/MADD domain containing 2D 3.14829
SFTPB surfactant protein B 3.12452
ZNF589 zinc finger protein 589 3.06786
CCL2 chemokine (C-C motif) ligand 2 2.99155
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.9821
UBQLN2 ubiquilin 2 2.88592
TEX10 testis expressed 10 2.82599
TAC4 tachykinin 4 (hemokinin) 2.71848
BFSP2 beaded filament structural protein 2, phakinin 2.65631
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6181
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.54456
CYCS cytochrome c, somatic 2.49708
SLC66A3 solute carrier family 66 member 3 2.49195
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.48296
KRT9 keratin 9, type I 2.43139
CELA3B chymotrypsin-like elastase family, member 3B 2.42769
CCNF cyclin F 2.36905
PLA2G2E phospholipase A2, group IIE 2.35935
GATA3 GATA binding protein 3 2.33676
INSL6 insulin-like 6 2.31599
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.30523
ALS2CL ALS2 C-terminal like 2.26824
CDX4 caudal type homeobox 4 2.25039
KRT33A keratin 33A, type I 2.23875
SMG6 SMG6 nonsense mediated mRNA decay factor 2.21027
TEC tec protein tyrosine kinase 2.20678
SCYL3 SCY1-like 3 (S. cerevisiae) 2.20405
PCDHGA8 protocadherin gamma subfamily A, 8 2.19436
CUZD1 CUB and zona pellucida-like domains 1 2.19372
CELA3A chymotrypsin-like elastase family, member 3A 2.17747
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.16821
CELA2B chymotrypsin-like elastase family, member 2B 2.15312
IRGC immunity-related GTPase family, cinema 2.13451
PRSS58 protease, serine, 58 2.12249
NOSIP nitric oxide synthase interacting protein 2.12236
DCAF4 DDB1 and CUL4 associated factor 4 2.12061
CTRB1 chymotrypsinogen B1 2.1167
CTRB2 chymotrypsinogen B2 2.10429
GUCA1B guanylate cyclase activator 1B (retina) 2.09117
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.08414
TTC21B tetratricopeptide repeat domain 21B 2.08057
NANOS3 nanos homolog 3 (Drosophila) 2.0788
AGRP agouti related neuropeptide 2.0782
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.05783
TP73 tumor protein p73 2.05778
LY86 lymphocyte antigen 86 2.05069
CLPS colipase, pancreatic 2.04357
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.02649
BCAS4 breast carcinoma amplified sequence 4 2.02497
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.02473
IHH indian hedgehog 2.023
TSPO2 translocator protein 2 2.02064
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.0195
EBLN2 endogenous Bornavirus-like nucleoprotein 2 2.01224
CNTN2 contactin 2 (axonal) 2.00886
COL19A1 collagen, type XIX, alpha 1 2.00181
WDR91 WD repeat domain 91 2.00082

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -8.63579
YME1L1 YME1-like 1 ATPase -6.46688
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.0823
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.96845
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.79904
TSPAN4 tetraspanin 4 -4.51538
TM9SF3 transmembrane 9 superfamily member 3 -4.25281
ZMIZ1 zinc finger, MIZ-type containing 1 -4.19155
KDM3A lysine (K)-specific demethylase 3A -3.91205
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.57869
ZDHHC6 zinc finger, DHHC-type containing 6 -3.57654
GLOD4 glyoxalase domain containing 4 -3.30494
CCNB2 cyclin B2 -2.94046
NGRN neugrin, neurite outgrowth associated -2.87122
ANKRD10 ankyrin repeat domain 10 -2.43947
RAI14 retinoic acid induced 14 -2.419
PTPRK protein tyrosine phosphatase, receptor type, K -2.3295
FAIM Fas apoptotic inhibitory molecule -2.31537
COG4 component of oligomeric golgi complex 4 -2.27313
FOS FBJ murine osteosarcoma viral oncogene homolog -2.26666
PCNA proliferating cell nuclear antigen -2.23914
BZW2 basic leucine zipper and W2 domains 2 -2.22028
WAC WW domain containing adaptor with coiled-coil -2.17981
MYL9 myosin, light chain 9, regulatory -2.03412
TLCD3A TLC domain containing 3A -2.03193
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.0122
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.00095