CRCGN012_HEPG2_24H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trisodium 5-oxo-1-(4-sulfonatophenyl)-4-[(e)-(4-sulfonatophenyl)diazenyl]-2,5-dihydro-1h-pyrazole-3-carboxylate 0.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN012_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.01423
CSK c-src tyrosine kinase 7.09599
PEX11A peroxisomal biogenesis factor 11 alpha 6.83581
CHN1 chimerin 1 5.1034
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.01845
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.91472
ANO1 anoctamin 1, calcium activated chloride channel 3.8571
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.8353
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.49527
LCN2 lipocalin 2 3.14516
STK10 serine/threonine kinase 10 2.97756
TIAM1 T-cell lymphoma invasion and metastasis 1 2.85207
CIAO3 cytosolic iron-sulfur assembly component 3 2.7911
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.45808
WDTC1 WD and tetratricopeptide repeats 1 2.31472
EPHB2 EPH receptor B2 2.17337
JADE2 jade family PHD finger 2 2.15609
CORO1A coronin, actin binding protein, 1A 2.06264
GSTZ1 glutathione S-transferase zeta 1 2.06187
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.01036
ZNF589 zinc finger protein 589 2.00215

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.64448
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.07232
GDF15 growth differentiation factor 15 -5.0
SLC35F2 solute carrier family 35, member F2 -4.29146
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.15615
PDLIM1 PDZ and LIM domain 1 -3.81793
VDAC1 voltage-dependent anion channel 1 -3.59046
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.43273
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.27273
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.04246
ZMIZ1 zinc finger, MIZ-type containing 1 -2.88316
CD320 CD320 molecule -2.67425
KDM3A lysine (K)-specific demethylase 3A -2.59418
RNF167 ring finger protein 167 -2.39213
GREM2 gremlin 2, DAN family BMP antagonist -2.36003
KRT31 keratin 31, type I -2.32282
FAM8A1 family with sequence similarity 8, member A1 -2.2719
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.24724
MTNAP1 mitochondrial nucleoid associated protein 1 -2.22634
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.16199
GALR2 galanin receptor 2 -2.10996
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.09902
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -2.083
EGF epidermal growth factor -2.05486
ZNF282 zinc finger protein 282 -2.04195
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa -2.03272
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.03092
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.02242
FGFR4 fibroblast growth factor receptor 4 -2.00251
CDIP1 cell death-inducing p53 target 1 -2.00011