| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | s,s'-1,4-dioxane-2,3-diyl o,o,o',o'-tetraethyl diphosphorodithioate 21.47 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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69 genes differentially expressed following the CRCGN012_HEPG2_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GSTZ1 | glutathione S-transferase zeta 1 | 6.54689 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.87234 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.78109 |
| LCN2 | lipocalin 2 | 4.65579 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 4.64713 |
| STIMATE | STIM activating enhancer | 4.548 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.43003 |
| CCNF | cyclin F | 4.37185 |
| E2F2 | E2F transcription factor 2 | 4.19707 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 4.18707 |
| EVL | Enah/Vasp-like | 4.1415 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.00469 |
| CBR3 | carbonyl reductase 3 | 3.50029 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.49257 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.42728 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 3.34529 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.05893 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.85646 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.8556 |
| CYCS | cytochrome c, somatic | 2.79672 |
| NOSIP | nitric oxide synthase interacting protein | 2.73734 |
| FZD7 | frizzled class receptor 7 | 2.57363 |
| GATA3 | GATA binding protein 3 | 2.45678 |
| CDC45 | cell division cycle 45 | 2.42129 |
| PMM2 | phosphomannomutase 2 | 2.21313 |
| TMEM9B | TMEM9 domain family, member B | 2.1818 |
| WFDC2 | WAP four-disulfide core domain 2 | 2.16127 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 2.15267 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.15164 |
| GPATCH8 | G patch domain containing 8 | 2.12145 |
| HELLS | helicase, lymphoid-specific | 2.10678 |
| PIGT | phosphatidylinositol glycan anchor biosynthesis, class T | 2.10068 |
| THRAP3 | thyroid hormone receptor associated protein 3 | 2.0647 |
| MCM3 | minichromosome maintenance complex component 3 | 2.05929 |
| CCDC85B | coiled-coil domain containing 85B | 2.03448 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIB3 | tribbles pseudokinase 3 | -8.94278 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -6.01855 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -5.74513 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.16184 |
| LAP3 | leucine aminopeptidase 3 | -5.13621 |
| LDHD | lactate dehydrogenase D | -4.96781 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.86559 |
| DNM1L | dynamin 1-like | -4.76375 |
| PLK1 | polo-like kinase 1 | -4.65215 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.64213 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.59992 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.42777 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -4.01661 |
| VAT1 | vesicle amine transport 1 | -3.93133 |
| MTFR1 | mitochondrial fission regulator 1 | -3.84108 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.76125 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.70392 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.69046 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.53179 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.46837 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.08627 |
| XPO7 | exportin 7 | -2.93467 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.89348 |
| NGRN | neugrin, neurite outgrowth associated | -2.76251 |
| YME1L1 | YME1-like 1 ATPase | -2.6651 |
| SOAT2 | sterol O-acyltransferase 2 | -2.56551 |
| CLTB | clathrin, light chain B | -2.53077 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -2.33397 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.25846 |
| GDF15 | growth differentiation factor 15 | -2.258 |
| NDRG1 | N-myc downstream regulated 1 | -2.14936 |
| UFSP2 | UFM1-specific peptidase 2 | -2.11823 |
| TES | testin LIM domain protein | -2.10902 |
| UBXN2B | UBX domain protein 2B | -2.01954 |
