CRCGN012_HEPG2_24H:J20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl 2-{(3z)-6-(ethylamino)-3-[(z)-ethylimino]-2,7-dimethyl-3h-xanthen-9-yl}benzoate hydrochloride 10.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

1091 genes differentially expressed following the CRCGN012_HEPG2_24H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
TXNRD1 thioredoxin reductase 1 10.0
INPP1 inositol polyphosphate-1-phosphatase 9.95744
TIMP2 TIMP metallopeptidase inhibitor 2 8.762
ANO1 anoctamin 1, calcium activated chloride channel 8.70085
ABHD4 abhydrolase domain containing 4 8.1099
FOSL1 FOS-like antigen 1 8.016
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 7.58381
MICALL1 MICAL-like 1 7.41852
UBQLN2 ubiquilin 2 7.10713
MVP major vault protein 7.08079
SQSTM1 sequestosome 1 7.04387
IGFBP3 insulin-like growth factor binding protein 3 6.85657
PNKP polynucleotide kinase 3'-phosphatase 6.49325
LRP10 low density lipoprotein receptor-related protein 10 6.43043
E2F2 E2F transcription factor 2 6.38616
ZFP36 ZFP36 ring finger protein 6.25895
GFPT1 glutamine--fructose-6-phosphate transaminase 1 6.23219
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 6.22011
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.82067
KLHL21 kelch-like family member 21 5.78317
DDIT4 DNA-damage-inducible transcript 4 5.58213
STX1A syntaxin 1A (brain) 5.55399
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 5.48461
VAT1 vesicle amine transport 1 5.42116
CAB39 calcium binding protein 39 5.22649
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.05269
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.04898
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.03815
KIFBP kinesin family binding protein 5.00507
CCDC92 coiled-coil domain containing 92 5.00064
FHL2 four and a half LIM domains 2 4.9999
SQOR sulfide quinone oxidoreductase 4.92374
AARS1 alanyl-tRNA synthetase 1 4.77955
IER3 immediate early response 3 4.74903
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 4.70338
CASC3 cancer susceptibility candidate 3 4.67264
NPC1 Niemann-Pick disease, type C1 4.65832
ASCC3 activating signal cointegrator 1 complex subunit 3 4.62981
H2BC21 H2B clustered histone 21 4.62924
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.55108
LCN2 lipocalin 2 4.5227
CHIC2 cysteine-rich hydrophobic domain 2 4.4857
PTPN12 protein tyrosine phosphatase, non-receptor type 12 4.48528
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.46336
UGDH UDP-glucose 6-dehydrogenase 4.45373
IL4R interleukin 4 receptor 4.38845
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 4.11595
PDGFA platelet-derived growth factor alpha polypeptide 4.1111
TERF2IP telomeric repeat binding factor 2, interacting protein 4.0861
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.06947
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.06707
UFM1 ubiquitin-fold modifier 1 4.06463
RAP1GAP RAP1 GTPase activating protein 4.05652
TP53BP2 tumor protein p53 binding protein 2 4.02895
RALB v-ral simian leukemia viral oncogene homolog B 4.02113
LSR lipolysis stimulated lipoprotein receptor 4.01971
ZYX zyxin 4.01045
ATF6 activating transcription factor 6 3.9517
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.92926
MBNL2 muscleblind-like splicing regulator 2 3.92488
MAP7D1 MAP7 domain containing 1 3.92277
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.91738
TMEM50A transmembrane protein 50A 3.76374
FOXO4 forkhead box O4 3.74934
PLK3 polo-like kinase 3 3.74231
CDK7 cyclin-dependent kinase 7 3.7395
ITGB5 integrin, beta 5 3.73771
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.71982
CCNA1 cyclin A1 3.70626
PRAF2 PRA1 domain family, member 2 3.69719
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.66136
JOSD1 Josephin domain containing 1 3.66064
SARS1 seryl-tRNA synthetase 1 3.64047
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.63452
DUSP3 dual specificity phosphatase 3 3.62485
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.58462
CNPY3 canopy FGF signaling regulator 3 3.50879
EXOC5 exocyst complex component 5 3.49369
FBXO7 F-box protein 7 3.46676
VAC14 Vac14 homolog (S. cerevisiae) 3.44724
FOXJ3 forkhead box J3 3.43729
PPARG peroxisome proliferator-activated receptor gamma 3.42799
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 3.42485
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 3.42297
SOCS2 suppressor of cytokine signaling 2 3.42203
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 3.40985
NANOS3 nanos homolog 3 (Drosophila) 3.39028
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 3.38653
PRR15L proline rich 15-like 3.37233
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 3.35501
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 3.34574
TEX10 testis expressed 10 3.34537
MGLL monoglyceride lipase 3.33503
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 3.33081
LPAR2 lysophosphatidic acid receptor 2 3.32318
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.31175
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 3.30996
CYTH2 cytohesin 2 3.29082
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.28687
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 3.282
ZFP69B ZFP69 zinc finger protein B 3.28073
NPDC1 neural proliferation, differentiation and control, 1 3.26906
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 3.25806
GOLT1B golgi transport 1B 3.24822
FABP2 fatty acid binding protein 2, intestinal 3.23987
MAPK13 mitogen-activated protein kinase 13 3.23486
OSGIN2 oxidative stress induced growth inhibitor family member 2 3.22969
TAS2R10 taste receptor, type 2, member 10 3.22012
GRB10 growth factor receptor-bound protein 10 3.21838
TOMM34 translocase of outer mitochondrial membrane 34 3.21555
PSPC1 paraspeckle component 1 3.20762
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.20396
DNASE2B deoxyribonuclease II beta 3.1958
IL37 interleukin 37 3.18322
STON1-GTF2A1L STON1-GTF2A1L readthrough 3.18152
SH3GLB1 SH3-domain GRB2-like endophilin B1 3.15637
EGR1 early growth response 1 3.15567
SNX16 sorting nexin 16 3.14999
TMEM156 transmembrane protein 156 3.14934
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 3.14338
DSG2 desmoglein 2 3.13125
CSNK1E casein kinase 1, epsilon 3.11139
FAM50A family with sequence similarity 50, member A 3.10943
PCNX1 pecanex 1 3.09992
PYGB phosphorylase, glycogen; brain 3.09578
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 3.09501
C2CD2 C2 calcium-dependent domain containing 2 3.08952
STK10 serine/threonine kinase 10 3.08868
EPS8 epidermal growth factor receptor pathway substrate 8 3.08373
PRKCH protein kinase C, eta 3.07805
ATG2B autophagy related 2B 3.06913
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 3.05146
RRAGC Ras-related GTP binding C 3.04793
TNIP1 TNFAIP3 interacting protein 1 3.04145
STRN4 striatin, calmodulin binding protein 4 3.03942
CRISP2 cysteine-rich secretory protein 2 3.03645
TRIM13 tripartite motif containing 13 3.02883
ZMIZ1 zinc finger, MIZ-type containing 1 3.02179
TICAM1 toll-like receptor adaptor molecule 1 3.01459
ANKRD10 ankyrin repeat domain 10 3.00322
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 2.99764
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.992
PPARD peroxisome proliferator-activated receptor delta 2.9836
GPC1 glypican 1 2.97267
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.96765
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.92927
UBXN7 UBX domain protein 7 2.92851
KIF13B kinesin family member 13B 2.92631
MYO1D myosin ID 2.92542
GAN gigaxonin 2.92325
TIGD6 tigger transposable element derived 6 2.92171
MAGIX MAGI family member, X-linked 2.92138
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.91535
RB1CC1 RB1-inducible coiled-coil 1 2.90942
RASAL2 RAS protein activator like 2 2.90413
GIPC1 GIPC PDZ domain containing family, member 1 2.90198
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.8982
SNW1 SNW domain containing 1 2.88792
NUP58 nucleoporin 58 2.87039
KDM5A lysine (K)-specific demethylase 5A 2.86649
MAP1S microtubule-associated protein 1S 2.86399
CFAP73 cilia and flagella associated protein 73 2.85269
EIF3D eukaryotic translation initiation factor 3, subunit D 2.84696
OCLN occludin 2.83564
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.81849
GADD45A growth arrest and DNA-damage-inducible, alpha 2.81834
MYH9 myosin, heavy chain 9, non-muscle 2.81808
DMTF1 cyclin D binding myb-like transcription factor 1 2.81234
TMEM144 transmembrane protein 144 2.80981
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.80657
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.80632
PHC2 polyhomeotic homolog 2 (Drosophila) 2.80041
MAP7 microtubule-associated protein 7 2.79123
SOX30 SRY (sex determining region Y)-box 30 2.78925
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 2.78801
CAMTA2 calmodulin binding transcription activator 2 2.78551
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 2.78522
KIAA0408 KIAA0408 2.78404
YIPF3 Yip1 domain family, member 3 2.78094
SNX7 sorting nexin 7 2.77255
SUN2 Sad1 and UNC84 domain containing 2 2.76586
DPP4 dipeptidyl-peptidase 4 2.76061
DYNLT1 dynein, light chain, Tctex-type 1 2.75176
KPNA4 karyopherin alpha 4 (importin alpha 3) 2.74734
MOSPD1 motile sperm domain containing 1 2.74675
HOMER2 homer scaffolding protein 2 2.74227
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.73659
SMR3A submaxillary gland androgen regulated protein 3A 2.7329
SAYSD1 SAYSVFN motif domain containing 1 2.7287
PXDC1 PX domain containing 1 2.72612
BCAR3 breast cancer anti-estrogen resistance 3 2.7188
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.71307
LAD1 ladinin 1 2.71101
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.70394
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.69632
BRDT bromodomain, testis-specific 2.69198
IST1 increased sodium tolerance 1 homolog (yeast) 2.68836
WBP4 WW domain binding protein 4 2.68706
CSRNP2 cysteine-serine-rich nuclear protein 2 2.68507
PINK1 PTEN induced putative kinase 1 2.68333
CTSL cathepsin L 2.68218
SERINC1 serine incorporator 1 2.68104
BTC betacellulin 2.68055
CYSLTR1 cysteinyl leukotriene receptor 1 2.68043
TRIB1 tribbles pseudokinase 1 2.67683
CLOCK clock circadian regulator 2.67529
UPP1 uridine phosphorylase 1 2.67237
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.66487
RAP1A RAP1A, member of RAS oncogene family 2.66191
HCFC2 host cell factor C2 2.64916
ZNF225 zinc finger protein 225 2.64846
ADAM2 ADAM metallopeptidase domain 2 2.64171
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.64105
HDLBP high density lipoprotein binding protein 2.63891
FBXO28 F-box protein 28 2.63825
GID4 GID complex subunit 4 2.63411
ZMYM2 zinc finger, MYM-type 2 2.63257
MACO1 macoilin 1 2.63094
GDI1 GDP dissociation inhibitor 1 2.62889
ZBTB6 zinc finger and BTB domain containing 6 2.62644
ATOSB atos homolog B 2.62176
TENT4A terminal nucleotidyltransferase 4A 2.62161
INTS6 integrator complex subunit 6 2.61343
PAQR5 progestin and adipoQ receptor family member V 2.60811
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.60559
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.60556
LARP6 La ribonucleoprotein domain family, member 6 2.59876
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.59695
MTMR6 myotubularin related protein 6 2.59278
ZNF516 zinc finger protein 516 2.59131
MBTD1 mbt domain containing 1 2.59127
FRK fyn-related Src family tyrosine kinase 2.58773
MFSD6 major facilitator superfamily domain containing 6 2.58772
IPO13 importin 13 2.58472
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.58447
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.58337
RNF115 ring finger protein 115 2.5774
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.57503
PTK2 protein tyrosine kinase 2 2.57278
TXNL4B thioredoxin-like 4B 2.57067
AFDN afadin, adherens junction formation factor 2.56869
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.5686
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.56788
CLDN4 claudin 4 2.56599
LOC128125814 uncharacterized LOC128125814 2.55944
RPE65 retinal pigment epithelium-specific protein 65kDa 2.5592
PEDS1 plasmanylethanolamine desaturase 1 2.55574
LIN37 lin-37 DREAM MuvB core complex component 2.55417
NABP1 nucleic acid binding protein 1 2.55411
SYNJ2BP synaptojanin 2 binding protein 2.55069
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.54998
LRRC8E leucine rich repeat containing 8 family, member E 2.54895
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.54812
IRAK1 interleukin-1 receptor-associated kinase 1 2.54506
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.54454
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.54405
CCDC144A coiled-coil domain containing 144A 2.53982
GALR1 galanin receptor 1 2.53793
ZXDB zinc finger, X-linked, duplicated B 2.53192
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.53167
LCOR ligand dependent nuclear receptor corepressor 2.51925
ADGB androglobin 2.51741
ZNF189 zinc finger protein 189 2.51213
LAMB4 laminin, beta 4 2.50914
TBC1D15 TBC1 domain family, member 15 2.50856
ZBTB33 zinc finger and BTB domain containing 33 2.50842
SPATA7 spermatogenesis associated 7 2.50457
SPO11 SPO11 meiotic protein covalently bound to DSB 2.50219
PRICKLE3 prickle homolog 3 (Drosophila) 2.50129
H2BC12 H2B clustered histone 12 2.50011
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.49988
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.49614
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.49544
ANKRD7 ankyrin repeat domain 7 2.49509
SLC49A3 solute carrier family 49 member 3 2.49434
MTCH1 mitochondrial carrier 1 2.49282
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.49144
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.48077
CCDC198 coiled-coil domain containing 198 2.47822
GLRA3 glycine receptor, alpha 3 2.47744
CYTH1 cytohesin 1 2.47632
TBC1D22B TBC1 domain family, member 22B 2.47573
TSC22D3 TSC22 domain family, member 3 2.46849
KNL1 kinetochore scaffold 1 2.46768
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.4675
PTPRK protein tyrosine phosphatase, receptor type, K 2.46514
SLC35F6 solute carrier family 35, member F6 2.46509
YARS1 tyrosyl-tRNA synthetase 1 2.46398
THSD7A thrombospondin, type I, domain containing 7A 2.46396
DGKE diacylglycerol kinase, epsilon 64kDa 2.46347
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.46097
CLDN8 claudin 8 2.46035
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.45843
IFNA5 interferon, alpha 5 2.45552
GABARAPL1 GABA(A) receptor-associated protein like 1 2.44869
PURG purine-rich element binding protein G 2.44702
TRAK2 trafficking protein, kinesin binding 2 2.44508
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.44458
TIMP1 TIMP metallopeptidase inhibitor 1 2.4443
LOC100996750 keratin-associated protein 4-7 2.44401
FAM135A family with sequence similarity 135, member A 2.44249
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.44199
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.43568
EGFR epidermal growth factor receptor 2.43547
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.43341
WDR13 WD repeat domain 13 2.43332
PSEN1 presenilin 1 2.43212
AGBL3 ATP/GTP binding protein-like 3 2.43187
GPR85 G protein-coupled receptor 85 2.43158
STX12 syntaxin 12 2.42988
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.4285
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.42645
KIF24 kinesin family member 24 2.42345
CDH9 cadherin 9, type 2 (T1-cadherin) 2.42318
ZNF674 zinc finger protein 674 2.42076
RNF220 ring finger protein 220 2.41679
ETFB electron-transfer-flavoprotein, beta polypeptide 2.41371
ST18 suppression of tumorigenicity 18, zinc finger 2.41343
SEMG2 semenogelin II 2.41325
IGF2R insulin-like growth factor 2 receptor 2.41325
DMRT1 doublesex and mab-3 related transcription factor 1 2.41231
ULK1 unc-51 like autophagy activating kinase 1 2.40619
HYOU1 hypoxia up-regulated 1 2.40615
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.40468
F2R coagulation factor II (thrombin) receptor 2.40424
ZNF227 zinc finger protein 227 2.40209
SMAD3 SMAD family member 3 2.39764
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.39618
SNX6 sorting nexin 6 2.39556
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.39503
TSBP1 testis expressed basic protein 1 2.39124
MTERF3 mitochondrial transcription termination factor 3 2.39001
IRX4 iroquois homeobox 4 2.38494
SNX13 sorting nexin 13 2.38294
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.38228
SENP6 SUMO1/sentrin specific peptidase 6 2.38029
UBR4 ubiquitin protein ligase E3 component n-recognin 4 2.37932
RAB27B RAB27B, member RAS oncogene family 2.37761
KRTAP1-3 keratin associated protein 1-3 2.37701
INHBB inhibin, beta B 2.37668
CDA cytidine deaminase 2.37624
LDHAL6B lactate dehydrogenase A-like 6B 2.37548
SNX27 sorting nexin family member 27 2.37373
UBA1 ubiquitin-like modifier activating enzyme 1 2.37166
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.37116
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.36605
ACOXL acyl-CoA oxidase-like 2.36446
TUT7 terminal uridylyl transferase 7 2.36351
RGS2 regulator of G-protein signaling 2 2.36267
GCM2 glial cells missing homolog 2 (Drosophila) 2.36014
BYSL bystin-like 2.35671
THAP9 THAP domain containing 9 2.3477
ITGA6 integrin, alpha 6 2.34553
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 2.3445
ZBTB35 zinc finger and BTB domain containing 35 2.34442
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.34297
IL2 interleukin 2 2.33492
MTFR1 mitochondrial fission regulator 1 2.33437
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.33302
DAZL deleted in azoospermia-like 2.33263
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.33224
SMTN smoothelin 2.33049
RAI14 retinoic acid induced 14 2.32887
MYH4 myosin, heavy chain 4, skeletal muscle 2.32764
MAGEB3 melanoma antigen family B3 2.3273
MAP1B microtubule-associated protein 1B 2.32631
ELL2 elongation factor, RNA polymerase II, 2 2.32518
FAM168B family with sequence similarity 168, member B 2.32308
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.32256
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.32191
GOLT1A golgi transport 1A 2.3216
AGTPBP1 ATP/GTP binding protein 1 2.32029
FEZF2 FEZ family zinc finger 2 2.31806
MECP2 methyl CpG binding protein 2 2.31672
MARK4 MAP/microtubule affinity-regulating kinase 4 2.31663
KRT81 keratin 81, type II 2.31486
ARL8B ADP-ribosylation factor-like 8B 2.31449
TMEM184B transmembrane protein 184B 2.3144
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.31429
ACVR1 activin A receptor, type I 2.30958
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.30891
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.30757
CLEC5A C-type lectin domain family 5, member A 2.3072
CPLX2 complexin 2 2.30631
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.30509
KLF7 Kruppel-like factor 7 (ubiquitous) 2.30388
DUSP6 dual specificity phosphatase 6 2.30312
CORO1A coronin, actin binding protein, 1A 2.303
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.30142
DOCK5 dedicator of cytokinesis 5 2.30058
ZNF780B zinc finger protein 780B 2.29893
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.29865
OCRL oculocerebrorenal syndrome of Lowe 2.29849
CYCS cytochrome c, somatic 2.2981
TDP2 tyrosyl-DNA phosphodiesterase 2 2.29468
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.29105
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.28915
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.28898
STX3 syntaxin 3 2.28723
ZNF234 zinc finger protein 234 2.28506
TUG1 taurine up-regulated 1 (non-protein coding) 2.28436
POGK pogo transposable element with KRAB domain 2.28393
RGCC regulator of cell cycle 2.28166
MLNR motilin receptor 2.27817
IQCC IQ motif containing C 2.27741
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.27708
R3HCC1L R3H domain and coiled-coil containing 1-like 2.27636
ADGRD2 adhesion G protein-coupled receptor D2 2.27592
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.27487
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.2739
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.27184
ZNF574 zinc finger protein 574 2.27182
GLRX glutaredoxin (thioltransferase) 2.26993
ARHGAP12 Rho GTPase activating protein 12 2.26681
TRIM33 tripartite motif containing 33 2.26653
SPICE1 spindle and centriole associated protein 1 2.2657
CCL27 chemokine (C-C motif) ligand 27 2.26445
CST1 cystatin SN 2.2601
SYNJ2 synaptojanin 2 2.26006
SIRT2 sirtuin 2 2.25961
EPN2 epsin 2 2.25955
ZNF157 zinc finger protein 157 2.25943
RNF103 ring finger protein 103 2.25942
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.25938
PBOV1 prostate and breast cancer overexpressed 1 2.25937
PQBP1 polyglutamine binding protein 1 2.25865
BMAL2 basic helix-loop-helix ARNT like 2 2.25805
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.25736
NCOA3 nuclear receptor coactivator 3 2.25696
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.25505
KLHL36 kelch-like family member 36 2.25341
SPATA1 spermatogenesis associated 1 2.25108
IL11 interleukin 11 2.25075
CDK17 cyclin-dependent kinase 17 2.24819
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.24792
SPX spexin hormone 2.24758
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.24703
SYNGR3 synaptogyrin 3 2.24648
PICALM phosphatidylinositol binding clathrin assembly protein 2.24564
OLAH oleoyl-ACP hydrolase 2.24433
INHBE inhibin, beta E 2.24378
CA6 carbonic anhydrase VI 2.24363
RFPL1 ret finger protein-like 1 2.2433
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.23924
IGFBP1 insulin-like growth factor binding protein 1 2.23559
JHY junctional cadherin complex regulator 2.23545
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.23444
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.23443
PRM2 protamine 2 2.23374
YAF2 YY1 associated factor 2 2.23338
TRIM49B tripartite motif containing 49B 2.23307
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.23131
ZNF292 zinc finger protein 292 2.23086
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.2294
RBMXL2 RNA binding motif protein, X-linked-like 2 2.22899
FGD6 FYVE, RhoGEF and PH domain containing 6 2.22876
ALAS1 5'-aminolevulinate synthase 1 2.22614
AKR1C4 aldo-keto reductase family 1, member C4 2.22602
NIT1 nitrilase 1 2.22565
YPEL5 yippee-like 5 (Drosophila) 2.2256
INSM1 insulinoma-associated 1 2.2243
ZNF557 zinc finger protein 557 2.22366
RTN4 reticulon 4 2.22316
NT5E 5'-nucleotidase, ecto (CD73) 2.22246
KRTAP9-9 keratin associated protein 9-9 2.22236
DRD1 dopamine receptor D1 2.21884
TFE3 transcription factor binding to IGHM enhancer 3 2.21805
FLNB filamin B, beta 2.216
ZNF80 zinc finger protein 80 2.21529
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.2152
CSRP1 cysteine and glycine-rich protein 1 2.21436
KDM3A lysine (K)-specific demethylase 3A 2.21387
KMT5A lysine methyltransferase 5A 2.21081
NT5C2 5'-nucleotidase, cytosolic II 2.20951
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.20922
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.20888
APOLD1 apolipoprotein L domain containing 1 2.2087
AKIRIN1 akirin 1 2.2086
HMGA1 high mobility group AT-hook 1 2.20827
ITGA1 integrin, alpha 1 2.20788
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.20504
AKAP4 A kinase (PRKA) anchor protein 4 2.20431
MRC1 mannose receptor, C type 1 2.20341
FURIN furin (paired basic amino acid cleaving enzyme) 2.20217
EXOC6B exocyst complex component 6B 2.19964
TNIP2 TNFAIP3 interacting protein 2 2.19903
SMR3B submaxillary gland androgen regulated protein 3B 2.19859
ELOVL4 ELOVL fatty acid elongase 4 2.19784
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.19645
USP53 ubiquitin specific peptidase 53 2.19522
DVL1 dishevelled segment polarity protein 1 2.19346
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.19307
TMC7 transmembrane channel-like 7 2.19266
HPSE heparanase 2.19257
SDCBP syndecan binding protein (syntenin) 2.1923
LIG4 ligase IV, DNA, ATP-dependent 2.19082
FBXO24 F-box protein 24 2.18945
CFAP68 cilia and flagella associated protein 68 2.18664
VSIG2 V-set and immunoglobulin domain containing 2 2.18546
DENND4C DENN/MADD domain containing 4C 2.18406
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.18366
POM121 POM121 transmembrane nucleoporin 2.1835
ARID4B AT rich interactive domain 4B (RBP1-like) 2.18121
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.18023
ALOXE3 arachidonate lipoxygenase 3 2.17887
GNPDA1 glucosamine-6-phosphate deaminase 1 2.1785
APOF apolipoprotein F 2.17775
GTPBP10 GTP-binding protein 10 (putative) 2.17458
CDCP1 CUB domain containing protein 1 2.17272
CNTNAP3B contactin associated protein-like 3B 2.1727
FRMD4B FERM domain containing 4B 2.17264
DGKA diacylglycerol kinase, alpha 80kDa 2.17225
KCTD9 potassium channel tetramerization domain containing 9 2.17161
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.17127
ATP11B ATPase, class VI, type 11B 2.17118
CFAP43 cilia and flagella associated protein 43 2.16939
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.16903
ZNF780A zinc finger protein 780A 2.16848
ZMYM5 zinc finger, MYM-type 5 2.16756
ZNF81 zinc finger protein 81 2.16346
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 2.16211
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.16104
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.15822
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.15679
MAGEB4 melanoma antigen family B4 2.15634
ACTN4 actinin, alpha 4 2.15612
CLEC2D C-type lectin domain family 2, member D 2.156
PORCN porcupine homolog (Drosophila) 2.15427
SSX1 synovial sarcoma, X breakpoint 1 2.15415
BRWD1 bromodomain and WD repeat domain containing 1 2.15109
VPS50 VPS50 subunit of EARP/GARPII complex 2.15046
PRKCD protein kinase C, delta 2.14958
RBM10 RNA binding motif protein 10 2.14845
MED8 mediator complex subunit 8 2.14805
LOC124900275 extensin-like 2.14744
PNRC1 proline-rich nuclear receptor coactivator 1 2.14688
AKT3 v-akt murine thymoma viral oncogene homolog 3 2.14511
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.14409
ITPKC inositol-trisphosphate 3-kinase C 2.14296
GRK4 G protein-coupled receptor kinase 4 2.14204
PLEC plectin 2.13999
PCDHGA11 protocadherin gamma subfamily A, 11 2.13964
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.13923
IMPG2 interphotoreceptor matrix proteoglycan 2 2.13893
IL4 interleukin 4 2.13679
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.13607
PLGLB2 plasminogen-like B2 2.1356
H2BC17 H2B clustered histone 17 2.13503
ZNF79 zinc finger protein 79 2.13483
APOD apolipoprotein D 2.13377
ELL elongation factor RNA polymerase II 2.13225
NPHP1 nephronophthisis 1 (juvenile) 2.13147
TMOD2 tropomodulin 2 (neuronal) 2.13109
PON3 paraoxonase 3 2.13103
DRD3 dopamine receptor D3 2.13099
CAPNS1 calpain, small subunit 1 2.13061
BCL7B B-cell CLL/lymphoma 7B 2.13006
DUSP8 dual specificity phosphatase 8 2.12937
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.12663
CD44 CD44 molecule (Indian blood group) 2.12599
ADGRE2 adhesion G protein-coupled receptor E2 2.12319
SMAD4 SMAD family member 4 2.122
FAM13C family with sequence similarity 13, member C 2.12155
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.12149
AFF4 AF4/FMR2 family, member 4 2.12103
PMM2 phosphomannomutase 2 2.11942
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.11903
MTRF1L mitochondrial translational release factor 1-like 2.11853
RAB9A RAB9A, member RAS oncogene family 2.11813
WDR33 WD repeat domain 33 2.1164
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.11529
UNC93A unc-93 homolog A (C. elegans) 2.1134
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.11217
SPAG9 sperm associated antigen 9 2.11156
SAP30BP SAP30 binding protein 2.11095
FAM193A family with sequence similarity 193, member A 2.11044
VEZT vezatin, adherens junctions transmembrane protein 2.10674
MNT MAX network transcriptional repressor 2.10557
MSH4 mutS homolog 4 2.1032
SPATA17 spermatogenesis associated 17 2.10173
KDM5C lysine (K)-specific demethylase 5C 2.10077
DNAH17 dynein, axonemal, heavy chain 17 2.10058
TEAD3 TEA domain family member 3 2.10036
LGALS4 lectin, galactoside-binding, soluble, 4 2.09997
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.09862
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.09809
VWA1 von Willebrand factor A domain containing 1 2.09554
TM4SF5 transmembrane 4 L six family member 5 2.09503
KIAA0513 KIAA0513 2.09443
NSUN7 NOP2/Sun domain family, member 7 2.09438
KLHL2 kelch-like family member 2 2.09302
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.08982
GABPB1 GA binding protein transcription factor, beta subunit 1 2.0898
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 2.08887
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.08769
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.08724
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 2.08719
GRB14 growth factor receptor-bound protein 14 2.08628
ETV6 ets variant 6 2.08593
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.08506
HABP4 hyaluronan binding protein 4 2.08488
ZNF410 zinc finger protein 410 2.08485
KRT23 keratin 23, type I 2.08481
RAB5A RAB5A, member RAS oncogene family 2.08459
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.08402
AKAP13 A kinase (PRKA) anchor protein 13 2.08316
PRPF3 pre-mRNA processing factor 3 2.0831
ZNF613 zinc finger protein 613 2.08197
RAP1GAP2 RAP1 GTPase activating protein 2 2.07973
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 2.07597
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.07368
TUBGCP3 tubulin, gamma complex associated protein 3 2.07348
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.07108
GPR135 G protein-coupled receptor 135 2.0708
NUCB2 nucleobindin 2 2.07071
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.07067
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.0704
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.07008
KDM6B lysine (K)-specific demethylase 6B 2.06985
SPATA31C1 SPATA31 subfamily C, member 1 2.06892
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.06836
FEV FEV (ETS oncogene family) 2.06777
KDM7A lysine (K)-specific demethylase 7A 2.06775
PAPOLB poly(A) polymerase beta (testis specific) 2.06719
CTPS1 CTP synthase 1 2.06575
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.0656
ITPRID2 ITPR interacting domain containing 2 2.06537
HNF4G hepatocyte nuclear factor 4, gamma 2.06362
HABP2 hyaluronan binding protein 2 2.06237
CRTC3 CREB regulated transcription coactivator 3 2.0623
DCTN1 dynactin 1 2.06038
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.05988
SPACA9 sperm acrosome associated 9 2.05844
MORC1 MORC family CW-type zinc finger 1 2.05701
CRYBA1 crystallin, beta A1 2.05549
HKDC1 hexokinase domain containing 1 2.05431
PRSS3 protease, serine, 3 2.05321
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.05296
USP27X ubiquitin specific peptidase 27, X-linked 2.05268
EPN3 epsin 3 2.05259
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.05098
ARL15 ADP-ribosylation factor-like 15 2.05009
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.04893
CCNJ cyclin J 2.04747
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 2.04713
TOX4 TOX high mobility group box family member 4 2.04506
PF4V1 platelet factor 4 variant 1 2.04473
GMEB1 glucocorticoid modulatory element binding protein 1 2.04461
WDR1 WD repeat domain 1 2.04321
ZNG1A Zn regulated GTPase metalloprotein activator 1A 2.04251
GPKOW G patch domain and KOW motifs 2.04124
MMRN1 multimerin 1 2.04009
EXOC1 exocyst complex component 1 2.03972
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 2.03715
RNF32 ring finger protein 32 2.03681
INHBA inhibin, beta A 2.03633
PTBP2 polypyrimidine tract binding protein 2 2.03615
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.03589
ATXN3 ataxin 3 2.03378
SCFD1 sec1 family domain containing 1 2.03234
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2.03004
PRND prion protein 2 (dublet) 2.02922
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.02828
RNF6 ring finger protein (C3H2C3 type) 6 2.02707
GPR39 G protein-coupled receptor 39 2.02622
PTPN21 protein tyrosine phosphatase, non-receptor type 21 2.02382
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.023
CTAGE8 CTAGE family, member 8 2.02274
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2.02232
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.02054
MTMR7 myotubularin related protein 7 2.02037
TEX12 testis expressed 12 2.02014
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 2.0181
NAPSA napsin A aspartic peptidase 2.01748
ZNF214 zinc finger protein 214 2.01669
ASCC1 activating signal cointegrator 1 complex subunit 1 2.01362
MEF2D myocyte enhancer factor 2D 2.01211
ADAM8 ADAM metallopeptidase domain 8 2.01155
RAB3B RAB3B, member RAS oncogene family 2.01155
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.00936
GARS1 glycyl-tRNA synthetase 1 2.00621
ERC2 ELKS/RAB6-interacting/CAST family member 2 2.00536
SLC35F2 solute carrier family 35, member F2 2.00463
FMO5 flavin containing monooxygenase 5 2.00415
IFRD1 interferon-related developmental regulator 1 2.00332
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2.00213
ATF3 activating transcription factor 3 2.0016
MTF2 metal response element binding transcription factor 2 2.00114
PCDHA9 protocadherin alpha 9 2.00082

decreased expression

Symbol Name Standardized Value
B4GAT1 beta-1,4-glucuronyltransferase 1 -10.0
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -9.55933
ALDOC aldolase C, fructose-bisphosphate -9.05995
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -8.99654
PARP1 poly (ADP-ribose) polymerase 1 -8.89911
CD320 CD320 molecule -8.61788
TCTN1 tectonic family member 1 -8.61346
PSRC1 proline/serine-rich coiled-coil 1 -8.4388
STMN1 stathmin 1 -7.90144
FGFR4 fibroblast growth factor receptor 4 -7.76314
CCNB2 cyclin B2 -7.75903
PGM1 phosphoglucomutase 1 -7.62868
PGAM4 phosphoglycerate mutase family member 4 -7.56421
TMEM109 transmembrane protein 109 -7.51607
COG7 component of oligomeric golgi complex 7 -7.22003
HMGA2 high mobility group AT-hook 2 -7.21871
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -6.83662
CDC20 cell division cycle 20 -6.73052
PCCB propionyl CoA carboxylase, beta polypeptide -6.71991
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.71293
MELK maternal embryonic leucine zipper kinase -6.70164
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.63269
CCNA2 cyclin A2 -6.43028
RPIA ribose 5-phosphate isomerase A -6.23151
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -6.18871
BLCAP bladder cancer associated protein -6.16413
CDK1 cyclin-dependent kinase 1 -6.16142
DERA deoxyribose-phosphate aldolase (putative) -6.14238
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -6.01502
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -5.93955
CCNB1 cyclin B1 -5.6045
AURKB aurora kinase B -5.58267
PROS1 protein S (alpha) -5.44122
HAT1 histone acetyltransferase 1 -5.4077
ECH1 enoyl CoA hydratase 1, peroxisomal -5.22422
NUP85 nucleoporin 85kDa -5.10433
POLR1A polymerase (RNA) I polypeptide A, 194kDa -5.04236
MYCBP MYC binding protein -5.00573
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.87578
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.8101
PLK1 polo-like kinase 1 -4.79896
LDHD lactate dehydrogenase D -4.7179
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -4.67322
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.65012
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -4.64897
TMEM97 transmembrane protein 97 -4.62984
HADH hydroxyacyl-CoA dehydrogenase -4.61595
MRPL12 mitochondrial ribosomal protein L12 -4.53727
ICAM3 intercellular adhesion molecule 3 -4.49463
SOAT2 sterol O-acyltransferase 2 -4.49221
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.47973
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.46613
TOP2A topoisomerase (DNA) II alpha 170kDa -4.4071
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.37897
GTF2A2 general transcription factor IIA, 2, 12kDa -4.36709
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.33325
MLEC malectin -4.27876
BIRC5 baculoviral IAP repeat containing 5 -4.27107
HSPB1 heat shock 27kDa protein 1 -4.26095
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.22876
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -4.21809
TFDP1 transcription factor Dp-1 -4.21434
RPA3 replication protein A3, 14kDa -4.14381
LBR lamin B receptor -4.12284
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.07369
NIPSNAP1 nipsnap homolog 1 (C. elegans) -4.07263
TRAP1 TNF receptor-associated protein 1 -4.04983
ADI1 acireductone dioxygenase 1 -4.03508
MSH2 mutS homolog 2 -4.0041
AKAP8 A kinase (PRKA) anchor protein 8 -3.97992
FBXL12 F-box and leucine-rich repeat protein 12 -3.91333
ISOC1 isochorismatase domain containing 1 -3.90243
NT5DC2 5'-nucleotidase domain containing 2 -3.8988
MRPL19 mitochondrial ribosomal protein L19 -3.8981
HMG20B high mobility group 20B -3.88066
SCAND1 SCAN domain containing 1 -3.84304
UBE2C ubiquitin-conjugating enzyme E2C -3.84229
TK1 thymidine kinase 1, soluble -3.83024
DUT deoxyuridine triphosphatase -3.82817
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.81411
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.80902
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.79523
ASF1B anti-silencing function 1B histone chaperone -3.78348
NLRP2B NLR family pyrin domain containing 2B -3.76546
GAA glucosidase, alpha; acid -3.70829
PCNA proliferating cell nuclear antigen -3.67721
MRPS2 mitochondrial ribosomal protein S2 -3.66965
MRPL11 mitochondrial ribosomal protein L11 -3.6646
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.66281
TMEM14A transmembrane protein 14A -3.64114
DSCC1 DNA replication and sister chromatid cohesion 1 -3.6327
TRIP13 thyroid hormone receptor interactor 13 -3.59514
OIP5 Opa interacting protein 5 -3.56992
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.55258
SCARB1 scavenger receptor class B, member 1 -3.54966
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.54552
MCM10 minichromosome maintenance complex component 10 -3.53171
MYL9 myosin, light chain 9, regulatory -3.50593
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.503
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.4973
THAP11 THAP domain containing 11 -3.47061
UNG uracil-DNA glycosylase -3.4591
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.45822
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -3.45543
PRCP prolylcarboxypeptidase (angiotensinase C) -3.43999
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.42838
CRTAP cartilage associated protein -3.42143
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.40867
CBR1 carbonyl reductase 1 -3.38721
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -3.37562
RFC5 replication factor C (activator 1) 5, 36.5kDa -3.37525
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.33033
CDC45 cell division cycle 45 -3.32062
FEN1 flap structure-specific endonuclease 1 -3.31877
PXMP2 peroxisomal membrane protein 2, 22kDa -3.31117
HEATR1 HEAT repeat containing 1 -3.31011
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.30868
BST2 bone marrow stromal cell antigen 2 -3.29539
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.26014
TEDC2 tubulin epsilon and delta complex 2 -3.24446
TSPAN6 tetraspanin 6 -3.24302
CDK4 cyclin-dependent kinase 4 -3.23202
ABHD14A abhydrolase domain containing 14A -3.22542
FANCG Fanconi anemia, complementation group G -3.22237
ZW10 zw10 kinetochore protein -3.18893
MYH10 myosin, heavy chain 10, non-muscle -3.18626
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -3.18588
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -3.16092
KIF11 kinesin family member 11 -3.15619
TBC1D10C TBC1 domain family, member 10C -3.13098
PTTG1 pituitary tumor-transforming 1 -3.12638
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.12567
CCNE1 cyclin E1 -3.12515
S100A4 S100 calcium binding protein A4 -3.11265
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.09861
NNT nicotinamide nucleotide transhydrogenase -3.09307
CKS1B CDC28 protein kinase regulatory subunit 1B -3.06043
MIS18A MIS18 kinetochore protein A -3.04767
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -3.04037
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -3.03306
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.99903
CENPS-CORT CENPS-CORT readthrough -2.99641
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.98784
SCCPDH saccharopine dehydrogenase (putative) -2.98391
BANF1 barrier to autointegration factor 1 -2.97348
DCTPP1 dCTP pyrophosphatase 1 -2.97279
CHMP6 charged multivesicular body protein 6 -2.96197
TRMT5 tRNA methyltransferase 5 -2.95422
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.93697
C2CD5 C2 calcium-dependent domain containing 5 -2.93562
ISOC2 isochorismatase domain containing 2 -2.93485
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.92675
NUP107 nucleoporin 107kDa -2.92446
LMNB1 lamin B1 -2.91231
KIF18B kinesin family member 18B -2.9037
VRK1 vaccinia related kinase 1 -2.89344
PGRMC1 progesterone receptor membrane component 1 -2.89264
HSPA14 heat shock 70kDa protein 14 -2.89237
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.88633
SNRPF small nuclear ribonucleoprotein polypeptide F -2.84461
GCDH glutaryl-CoA dehydrogenase -2.83756
CENPX centromere protein X -2.83595
SH3D19 SH3 domain containing 19 -2.82086
TOR3A torsin family 3, member A -2.81831
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.81119
MRPS22 mitochondrial ribosomal protein S22 -2.8103
CIRBP cold inducible RNA binding protein -2.76896
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.75673
HSPE1 heat shock 10kDa protein 1 -2.75425
CDCA8 cell division cycle associated 8 -2.74965
SEPHS1 selenophosphate synthetase 1 -2.74832
MRPL16 mitochondrial ribosomal protein L16 -2.73818
NUP37 nucleoporin 37kDa -2.73645
KIF15 kinesin family member 15 -2.73057
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.72827
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.71781
EXTL2 exostosin-like glycosyltransferase 2 -2.71032
SORD sorbitol dehydrogenase -2.70056
KIF4A kinesin family member 4A -2.68411
DPH2 DPH2 homolog (S. cerevisiae) -2.68036
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.67667
AURKA aurora kinase A -2.67327
FANCI Fanconi anemia, complementation group I -2.67147
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.65247
PKNOX2 PBX/knotted 1 homeobox 2 -2.6436
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.64252
PRR5 proline rich 5 (renal) -2.64065
STIL SCL/TAL1 interrupting locus -2.63805
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.63233
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.62529
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.62377
RUVBL1 RuvB-like AAA ATPase 1 -2.61924
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.61914
NCAPD3 non-SMC condensin II complex, subunit D3 -2.61809
SPPL2A signal peptide peptidase like 2A -2.61026
PARN poly(A)-specific ribonuclease -2.60694
CDC25A cell division cycle 25A -2.60194
SPDL1 spindle apparatus coiled-coil protein 1 -2.6017
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.59633
KIFC1 kinesin family member C1 -2.59632
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.5949
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.59174
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.58867
AUNIP aurora kinase A and ninein interacting protein -2.57324
SAMM50 SAMM50 sorting and assembly machinery component -2.57306
PFAS phosphoribosylformylglycinamidine synthase -2.57086
TFB2M transcription factor B2, mitochondrial -2.56806
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.56546
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.56392
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.54901
PYCR3 pyrroline-5-carboxylate reductase 3 -2.54679
MCM5 minichromosome maintenance complex component 5 -2.54587
MRPS7 mitochondrial ribosomal protein S7 -2.54459
GID8 GID complex subunit 8 -2.53289
RPL26L1 ribosomal protein L26-like 1 -2.52051
CD83 CD83 molecule -2.51902
DEK DEK proto-oncogene -2.51264
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.5121
RFC4 replication factor C (activator 1) 4, 37kDa -2.50859
TSPAN3 tetraspanin 3 -2.50852
VIPR1 vasoactive intestinal peptide receptor 1 -2.50832
AMDHD2 amidohydrolase domain containing 2 -2.50289
ELAVL1 ELAV like RNA binding protein 1 -2.4901
TMX1 thioredoxin-related transmembrane protein 1 -2.48972
DEXI Dexi homolog (mouse) -2.48882
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.47839
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.47698
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.4752
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.46774
ANAPC15 anaphase promoting complex subunit 15 -2.45951
NCAPH non-SMC condensin I complex, subunit H -2.45249
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.44872
FZD7 frizzled class receptor 7 -2.44178
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.43992
MRPL35 mitochondrial ribosomal protein L35 -2.43316
PYCARD PYD and CARD domain containing -2.43221
ATP5MF ATP synthase membrane subunit f -2.42777
PDIA6 protein disulfide isomerase family A, member 6 -2.42492
CDK2 cyclin-dependent kinase 2 -2.42224
HMOX1 heme oxygenase 1 -2.41713
LAGE3 L antigen family, member 3 -2.41415
GYS1 glycogen synthase 1 (muscle) -2.40962
LYRM9 LYR motif containing 9 -2.40527
SKIC8 SKI8 subunit of superkiller complex -2.40281
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.39644
PARG poly (ADP-ribose) glycohydrolase -2.39205
DENND2D DENN/MADD domain containing 2D -2.38878
SDF2L1 stromal cell-derived factor 2-like 1 -2.37833
RBM15B RNA binding motif protein 15B -2.37496
MSH6 mutS homolog 6 -2.37395
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.36485
NUP93 nucleoporin 93kDa -2.36468
WASF3 WAS protein family, member 3 -2.35652
XPO1 exportin 1 -2.35628
PCNT pericentrin -2.35338
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.3516
DHFR dihydrofolate reductase -2.3423
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.34152
FZD4 frizzled class receptor 4 -2.34
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.33818
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.33681
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.33191
IGFLR1 IGF-like family receptor 1 -2.32552
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.32512
NENF neudesin neurotrophic factor -2.31969
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.31909
NCAPG2 non-SMC condensin II complex, subunit G2 -2.31675
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.31092
APEH acylaminoacyl-peptide hydrolase -2.30438
LAP3 leucine aminopeptidase 3 -2.30279
POLK polymerase (DNA directed) kappa -2.30208
UCKL1 uridine-cytidine kinase 1-like 1 -2.29813
ZWINT ZW10 interacting kinetochore protein -2.2938
HMGN2 high mobility group nucleosomal binding domain 2 -2.28829
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.28739
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.28037
MX2 MX dynamin-like GTPase 2 -2.27818
CPNE3 copine III -2.27591
ICMT isoprenylcysteine carboxyl methyltransferase -2.27346
THEM6 thioesterase superfamily member 6 -2.27022
HDAC2 histone deacetylase 2 -2.26731
ZNF586 zinc finger protein 586 -2.26509
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.26088
CHAD chondroadherin -2.2604
ERCC6L excision repair cross-complementation group 6-like -2.25939
PCOLCE procollagen C-endopeptidase enhancer -2.25845
FKBP3 FK506 binding protein 3, 25kDa -2.2529
EMC9 ER membrane protein complex subunit 9 -2.25158
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.25141
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.25107
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.25081
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.25026
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.2497
LYRM1 LYR motif containing 1 -2.24644
GAMT guanidinoacetate N-methyltransferase -2.24594
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.24487
TLCD3A TLC domain containing 3A -2.24155
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.24104
COX5B cytochrome c oxidase subunit Vb -2.23927
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.23887
SFXN1 sideroflexin 1 -2.23713
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.23213
MAT2B methionine adenosyltransferase II, beta -2.22986
ZDHHC24 zinc finger, DHHC-type containing 24 -2.22916
QTRT1 queuine tRNA-ribosyltransferase 1 -2.22633
RNASE7 ribonuclease, RNase A family, 7 -2.21808
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21747
GLOD4 glyoxalase domain containing 4 -2.21325
HIRA histone cell cycle regulator -2.21305
WDR18 WD repeat domain 18 -2.21108
MRPL48 mitochondrial ribosomal protein L48 -2.20548
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.20159
UBL5 ubiquitin-like 5 -2.19509
MSMO1 methylsterol monooxygenase 1 -2.19461
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.19243
COA3 cytochrome c oxidase assembly factor 3 -2.19234
RPL29 ribosomal protein L29 -2.18828
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.18179
GFUS GDP-L-fucose synthase -2.17837
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.1756
PDF peptide deformylase (mitochondrial) -2.17174
THOP1 thimet oligopeptidase 1 -2.17012
RACGAP1 Rac GTPase activating protein 1 -2.1671
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.16655
RFC2 replication factor C (activator 1) 2, 40kDa -2.16206
VAV3 vav 3 guanine nucleotide exchange factor -2.15814
FUS FUS RNA binding protein -2.15733
ORC6 origin recognition complex, subunit 6 -2.15035
SIVA1 SIVA1, apoptosis-inducing factor -2.15012
ZNF544 zinc finger protein 544 -2.14404
HOOK2 hook microtubule-tethering protein 2 -2.14326
CETN2 centrin, EF-hand protein, 2 -2.14033
GEMIN6 gem (nuclear organelle) associated protein 6 -2.13786
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.13747
LZTFL1 leucine zipper transcription factor-like 1 -2.13625
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.13385
MDH1 malate dehydrogenase 1, NAD (soluble) -2.1335
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.13339
LOC112694756 uncharaterized LOC112694756 -2.13204
NHP2 NHP2 ribonucleoprotein -2.12779
CBX3 chromobox homolog 3 -2.12361
RNPS1 RNA binding protein S1, serine-rich domain -2.11678
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.11562
METTL9 methyltransferase like 9 -2.11277
HEBP1 heme binding protein 1 -2.11094
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.10912
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.10713
SNRPA small nuclear ribonucleoprotein polypeptide A -2.10049
BNC2 basonuclin 2 -2.10002
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.0977
EXOSC9 exosome component 9 -2.09455
MRPL39 mitochondrial ribosomal protein L39 -2.09301
PIMREG PICALM interacting mitotic regulator -2.09236
CETN3 centrin, EF-hand protein, 3 -2.09187
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.09112
NME5 NME/NM23 family member 5 -2.09099
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.08556
ZNF239 zinc finger protein 239 -2.08382
CYB561D2 cytochrome b561 family, member D2 -2.0831
SLC2A4RG SLC2A4 regulator -2.08117
NEK4 NIMA-related kinase 4 -2.0794
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.07628
NMRK2 nicotinamide riboside kinase 2 -2.07471
NDC1 NDC1 transmembrane nucleoporin -2.07334
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.06894
PARPBP PARP1 binding protein -2.06737
HMGB2 high mobility group box 2 -2.06717
TMCO1 transmembrane and coiled-coil domains 1 -2.06415
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.06043
MCM3 minichromosome maintenance complex component 3 -2.05928
OCEL1 occludin/ELL domain containing 1 -2.05753
MDC1 mediator of DNA-damage checkpoint 1 -2.05442
MYO15A myosin XVA -2.05419
TSNAX translin-associated factor X -2.05035
TIMELESS timeless circadian clock -2.04907
UNC119 unc-119 homolog (C. elegans) -2.0484
HMBS hydroxymethylbilane synthase -2.04667
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.04635
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.04569
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.04211
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.04205
LOC124907782 dual specificity protein phosphatase 22 -2.04166
RAB1B RAB1B, member RAS oncogene family -2.03926
SRSF2 serine/arginine-rich splicing factor 2 -2.03804
TMEM100 transmembrane protein 100 -2.03611
STIMATE STIM activating enhancer -2.03443
BCL7C B-cell CLL/lymphoma 7C -2.0321
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) -2.02978
DHCR7 7-dehydrocholesterol reductase -2.02861
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.02165
TPM3 tropomyosin 3 -2.02068
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02014
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.01895
PDHB pyruvate dehydrogenase (lipoamide) beta -2.01636
SRSF3 serine/arginine-rich splicing factor 3 -2.01551
TMEM9B TMEM9 domain family, member B -2.01534
TTC38 tetratricopeptide repeat domain 38 -2.01188
C1QBP complement component 1, q subcomponent binding protein -2.01055
MRPS16 mitochondrial ribosomal protein S16 -2.00891
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.00692
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.00627