CRCGN012_HEPG2_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl 2-{(3z)-6-(ethylamino)-3-[(z)-ethylimino]-2,7-dimethyl-3h-xanthen-9-yl}benzoate hydrochloride 0.64 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

451 genes differentially expressed following the CRCGN012_HEPG2_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP1 inositol polyphosphate-1-phosphatase 9.26689
TRIB3 tribbles pseudokinase 3 7.47243
TXNRD1 thioredoxin reductase 1 6.98346
LRP10 low density lipoprotein receptor-related protein 10 6.48097
LCN2 lipocalin 2 6.37883
TIMP2 TIMP metallopeptidase inhibitor 2 6.33167
CBR3 carbonyl reductase 3 6.01855
GFOD1 glucose-fructose oxidoreductase domain containing 1 6.00137
SQSTM1 sequestosome 1 5.72654
CDPF1 cysteine-rich, DPF motif domain containing 1 5.69098
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.50391
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.37579
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.18255
FOSL1 FOS-like antigen 1 5.13423
MVP major vault protein 5.0502
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.00858
CNPY3 canopy FGF signaling regulator 3 4.99304
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.80865
C2CD2 C2 calcium-dependent domain containing 2 4.77917
DDIT4 DNA-damage-inducible transcript 4 4.67285
ACOT9 acyl-CoA thioesterase 9 4.65584
BZW2 basic leucine zipper and W2 domains 2 4.59186
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.52198
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.52112
TRIB1 tribbles pseudokinase 1 4.49611
ADGRE5 adhesion G protein-coupled receptor E5 4.49365
GFPT1 glutamine--fructose-6-phosphate transaminase 1 4.43093
SQOR sulfide quinone oxidoreductase 4.3636
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.36163
STX1A syntaxin 1A (brain) 4.34008
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 4.339
EGR1 early growth response 1 4.31416
EPHB2 EPH receptor B2 4.26183
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 4.17677
UBQLN2 ubiquilin 2 4.10907
IL4R interleukin 4 receptor 4.09093
SLC35F2 solute carrier family 35, member F2 4.07878
IER3 immediate early response 3 4.06421
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.8803
CAB39 calcium binding protein 39 3.83201
UGDH UDP-glucose 6-dehydrogenase 3.75718
GRB10 growth factor receptor-bound protein 10 3.74939
KIFBP kinesin family binding protein 3.69167
ZFP36 ZFP36 ring finger protein 3.54913
TOMM34 translocase of outer mitochondrial membrane 34 3.49925
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.48123
LGALS8 lectin, galactoside-binding, soluble, 8 3.4567
PRAF2 PRA1 domain family, member 2 3.43215
DYNLT3 dynein, light chain, Tctex-type 3 3.37385
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.3503
SARS1 seryl-tRNA synthetase 1 3.32778
NPDC1 neural proliferation, differentiation and control, 1 3.31733
DSG2 desmoglein 2 3.31547
RAP1GAP RAP1 GTPase activating protein 3.30928
WARS1 tryptophanyl-tRNA synthetase 1 3.27912
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.24853
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.17585
CSK c-src tyrosine kinase 3.17034
YARS1 tyrosyl-tRNA synthetase 1 3.16169
GLRX glutaredoxin (thioltransferase) 3.15569
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.12333
VGLL4 vestigial-like family member 4 3.06166
MICALL1 MICAL-like 1 3.03308
NANOS3 nanos homolog 3 (Drosophila) 3.02859
PTPN12 protein tyrosine phosphatase, non-receptor type 12 3.01879
RALB v-ral simian leukemia viral oncogene homolog B 2.97836
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.96849
AARS1 alanyl-tRNA synthetase 1 2.95688
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.93376
PPARD peroxisome proliferator-activated receptor delta 2.93109
CASC3 cancer susceptibility candidate 3 2.93068
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.92626
PRKCQ protein kinase C, theta 2.90663
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.89578
NMU neuromedin U 2.89281
CHIC2 cysteine-rich hydrophobic domain 2 2.87602
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.86066
BAMBI BMP and activin membrane-bound inhibitor 2.8393
SNX6 sorting nexin 6 2.81141
GIPC1 GIPC PDZ domain containing family, member 1 2.77019
TRAK2 trafficking protein, kinesin binding 2 2.75109
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.71904
DUSP3 dual specificity phosphatase 3 2.71467
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.70042
PXDC1 PX domain containing 1 2.69986
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.69746
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.6973
MBNL2 muscleblind-like splicing regulator 2 2.67322
SMAD3 SMAD family member 3 2.67186
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.65868
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.63865
VEZT vezatin, adherens junctions transmembrane protein 2.62717
TERF2IP telomeric repeat binding factor 2, interacting protein 2.60843
E2F2 E2F transcription factor 2 2.59706
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.5795
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.52725
TCEAL4 transcription elongation factor A (SII)-like 4 2.51362
CARS1 cysteinyl-tRNA synthetase 1 2.50579
FOXO4 forkhead box O4 2.49844
IGFBP3 insulin-like growth factor binding protein 3 2.49471
WASHC5 WASH complex subunit 5 2.481
GTPBP2 GTP binding protein 2 2.47339
TES testin LIM domain protein 2.47252
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.45348
ZZZ3 zinc finger, ZZ-type containing 3 2.45232
ITGB5 integrin, beta 5 2.44894
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.42591
JOSD1 Josephin domain containing 1 2.41992
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.4154
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.39854
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.39518
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.38639
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.3764
CCNA1 cyclin A1 2.37355
TBP TATA box binding protein 2.36967
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.36921
YIPF3 Yip1 domain family, member 3 2.36664
CLTB clathrin, light chain B 2.35815
ARHGAP22 Rho GTPase activating protein 22 2.33483
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.32632
IFRD1 interferon-related developmental regulator 1 2.32178
SOX4 SRY (sex determining region Y)-box 4 2.31648
HTRA1 HtrA serine peptidase 1 2.30842
ATF6 activating transcription factor 6 2.30301
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.29802
IGF2R insulin-like growth factor 2 receptor 2.2979
BECN1 beclin 1, autophagy related 2.29611
BYSL bystin-like 2.29525
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.28406
CAMTA2 calmodulin binding transcription activator 2 2.27723
SH2B3 SH2B adaptor protein 3 2.26044
SYNGR3 synaptogyrin 3 2.25847
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.24823
UBR4 ubiquitin protein ligase E3 component n-recognin 4 2.24786
SHB Src homology 2 domain containing adaptor protein B 2.22989
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.22197
CCDC92 coiled-coil domain containing 92 2.21701
SFRP5 secreted frizzled-related protein 5 2.21047
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.20895
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.20327
ASCC3 activating signal cointegrator 1 complex subunit 3 2.19904
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.19689
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.19481
GARS1 glycyl-tRNA synthetase 1 2.19016
POLH polymerase (DNA directed), eta 2.18407
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.18241
CDK7 cyclin-dependent kinase 7 2.18233
IDO1 indoleamine 2,3-dioxygenase 1 2.16551
MARS1 methionyl-tRNA synthetase 1 2.15932
EHD4 EH-domain containing 4 2.14896
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.14348
IGFBP1 insulin-like growth factor binding protein 1 2.12546
SNPH syntaphilin 2.11982
TARS1 threonyl-tRNA synthetase 1 2.11669
UFM1 ubiquitin-fold modifier 1 2.10748
TMEM19 transmembrane protein 19 2.1071
ZMIZ1 zinc finger, MIZ-type containing 1 2.10691
NOTCH2NLB notch 2 N-terminal like B 2.10557
MBTD1 mbt domain containing 1 2.10354
LOC128125814 uncharacterized LOC128125814 2.09807
POM121 POM121 transmembrane nucleoporin 2.09417
DENND4A DENN/MADD domain containing 4A 2.09291
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.09082
EXOC1 exocyst complex component 1 2.08963
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.08911
AXL AXL receptor tyrosine kinase 2.08889
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.08623
MYH9 myosin, heavy chain 9, non-muscle 2.08165
RIOK3 RIO kinase 3 2.07485
NUP58 nucleoporin 58 2.0602
GDI1 GDP dissociation inhibitor 1 2.05988
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.0562
ATG2B autophagy related 2B 2.05052
KDM5C lysine (K)-specific demethylase 5C 2.04454
ROM1 retinal outer segment membrane protein 1 2.04107
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.03863
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.03655
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.03219
RTCA RNA 3'-terminal phosphate cyclase 2.03012
CSNK1E casein kinase 1, epsilon 2.01661
ZFAND1 zinc finger, AN1-type domain 1 2.01268
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.00473
MBNL1 muscleblind-like splicing regulator 1 2.00339
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.00193

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -9.66731
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -9.02335
NT5DC2 5'-nucleotidase domain containing 2 -8.04136
B4GAT1 beta-1,4-glucuronyltransferase 1 -8.03783
ISOC1 isochorismatase domain containing 1 -7.85918
MELK maternal embryonic leucine zipper kinase -7.83976
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -7.79138
HAT1 histone acetyltransferase 1 -7.27487
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -7.00981
PSRC1 proline/serine-rich coiled-coil 1 -6.88033
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -6.86855
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.78601
ALDOC aldolase C, fructose-bisphosphate -6.7367
PLK1 polo-like kinase 1 -6.56917
CCNA2 cyclin A2 -6.5429
AURKB aurora kinase B -6.27984
ZNF586 zinc finger protein 586 -6.14986
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -6.13755
ADI1 acireductone dioxygenase 1 -5.83797
CDK1 cyclin-dependent kinase 1 -5.82744
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.70971
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.68904
CD320 CD320 molecule -5.68399
SOAT2 sterol O-acyltransferase 2 -5.62822
PCNA proliferating cell nuclear antigen -5.59065
NFIL3 nuclear factor, interleukin 3 regulated -5.56654
CDC20 cell division cycle 20 -5.29792
NUP85 nucleoporin 85kDa -5.14973
POLR1A polymerase (RNA) I polypeptide A, 194kDa -5.06077
PGM1 phosphoglucomutase 1 -4.98402
BIRC5 baculoviral IAP repeat containing 5 -4.94197
TOP2A topoisomerase (DNA) II alpha 170kDa -4.78919
TMEM97 transmembrane protein 97 -4.76344
ASF1B anti-silencing function 1B histone chaperone -4.69435
HADH hydroxyacyl-CoA dehydrogenase -4.5832
COG7 component of oligomeric golgi complex 7 -4.56988
COG4 component of oligomeric golgi complex 4 -4.46873
PGAM4 phosphoglycerate mutase family member 4 -4.44108
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.4219
CCNB1 cyclin B1 -4.34668
ZDHHC6 zinc finger, DHHC-type containing 6 -4.33146
STMN1 stathmin 1 -4.32303
GINS2 GINS complex subunit 2 (Psf2 homolog) -4.17358
KIFC1 kinesin family member C1 -4.13637
CHEK2 checkpoint kinase 2 -4.07038
ZW10 zw10 kinetochore protein -3.99343
FGFR4 fibroblast growth factor receptor 4 -3.98139
PARP1 poly (ADP-ribose) polymerase 1 -3.97727
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.94179
ECH1 enoyl CoA hydratase 1, peroxisomal -3.89631
TK1 thymidine kinase 1, soluble -3.85847
CCNB2 cyclin B2 -3.78392
DDB2 damage-specific DNA binding protein 2, 48kDa -3.68584
ICAM3 intercellular adhesion molecule 3 -3.66762
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.63468
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.61278
FBXL12 F-box and leucine-rich repeat protein 12 -3.57163
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.56293
MCM10 minichromosome maintenance complex component 10 -3.56089
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -3.52905
FEN1 flap structure-specific endonuclease 1 -3.4872
KIF15 kinesin family member 15 -3.48702
TRIP13 thyroid hormone receptor interactor 13 -3.45644
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.4451
FOXM1 forkhead box M1 -3.42223
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.40304
TFDP1 transcription factor Dp-1 -3.38022
CHAF1A chromatin assembly factor 1, subunit A (p150) -3.3615
MLEC malectin -3.3522
NCAPD2 non-SMC condensin I complex, subunit D2 -3.27383
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.25805
FANCG Fanconi anemia, complementation group G -3.2541
AURKA aurora kinase A -3.20473
CCNF cyclin F -3.20112
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.19152
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -3.19021
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.18596
DERA deoxyribose-phosphate aldolase (putative) -3.18161
MIS18A MIS18 kinetochore protein A -3.14252
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.11674
DSCC1 DNA replication and sister chromatid cohesion 1 -3.11219
RMI1 RecQ mediated genome instability 1 -3.10688
NCAPH non-SMC condensin I complex, subunit H -3.09848
MNS1 meiosis-specific nuclear structural 1 -3.09701
MSMO1 methylsterol monooxygenase 1 -3.06854
TROAP trophinin associated protein -3.03071
LMNB1 lamin B1 -3.02541
HSPB1 heat shock 27kDa protein 1 -3.01055
CTCF CCCTC-binding factor (zinc finger protein) -2.99851
HSPA1A heat shock 70kDa protein 1A -2.99159
TRMT5 tRNA methyltransferase 5 -2.98766
CDC25A cell division cycle 25A -2.97985
NEK11 NIMA-related kinase 11 -2.95585
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.9532
MSH6 mutS homolog 6 -2.92896
CKS1B CDC28 protein kinase regulatory subunit 1B -2.91397
RFC4 replication factor C (activator 1) 4, 37kDa -2.90081
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.87247
RPIA ribose 5-phosphate isomerase A -2.86538
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.82936
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.82643
PGRMC1 progesterone receptor membrane component 1 -2.818
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.81661
VDAC1 voltage-dependent anion channel 1 -2.8052
LBR lamin B receptor -2.79701
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.79354
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.78805
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.77246
MYCBP MYC binding protein -2.7661
ZWINT ZW10 interacting kinetochore protein -2.75105
TBC1D10C TBC1 domain family, member 10C -2.72972
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.7289
ZNF134 zinc finger protein 134 -2.72633
RPA3 replication protein A3, 14kDa -2.72187
KIF4A kinesin family member 4A -2.71967
DHCR7 7-dehydrocholesterol reductase -2.71815
NASP nuclear autoantigenic sperm protein (histone-binding) -2.71005
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.70879
DUT deoxyuridine triphosphatase -2.66334
STIMATE STIM activating enhancer -2.64617
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.64214
CDT1 chromatin licensing and DNA replication factor 1 -2.63498
NCAPG2 non-SMC condensin II complex, subunit G2 -2.63393
PARN poly(A)-specific ribonuclease -2.62635
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.62137
GTF2A2 general transcription factor IIA, 2, 12kDa -2.6213
KIF11 kinesin family member 11 -2.61525
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.59667
CTSL cathepsin L -2.57568
NUP107 nucleoporin 107kDa -2.57565
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.56947
CDCA8 cell division cycle associated 8 -2.56506
CDC6 cell division cycle 6 -2.56221
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.56174
RAD51AP1 RAD51 associated protein 1 -2.56151
PRCP prolylcarboxypeptidase (angiotensinase C) -2.55659
PYCR3 pyrroline-5-carboxylate reductase 3 -2.55373
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.55173
HMOX1 heme oxygenase 1 -2.53827
AMDHD2 amidohydrolase domain containing 2 -2.53665
DHFR dihydrofolate reductase -2.52762
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.52742
FANCI Fanconi anemia, complementation group I -2.51502
GNAS GNAS complex locus -2.50394
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.49444
UBE2C ubiquitin-conjugating enzyme E2C -2.48684
TEDC2 tubulin epsilon and delta complex 2 -2.47779
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.47523
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.46199
IFT81 intraflagellar transport 81 -2.45614
KIF18B kinesin family member 18B -2.45596
ISOC2 isochorismatase domain containing 2 -2.44493
RFC3 replication factor C (activator 1) 3, 38kDa -2.4439
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.44378
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.44171
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.43424
TSNAXIP1 translin-associated factor X interacting protein 1 -2.43039
CDCA3 cell division cycle associated 3 -2.42427
DSN1 DSN1, MIS12 kinetochore complex component -2.4242
ZNF443 zinc finger protein 443 -2.41763
GET1 guided entry of tail-anchored proteins factor 1 -2.40604
GYS1 glycogen synthase 1 (muscle) -2.39258
MXD3 MAX dimerization protein 3 -2.38688
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.38202
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.36586
CDK2 cyclin-dependent kinase 2 -2.36325
TRAIP TRAF interacting protein -2.36051
FAM111A family with sequence similarity 111, member A -2.34823
ELAVL1 ELAV like RNA binding protein 1 -2.33965
DEPDC1 DEP domain containing 1 -2.33874
NEK2 NIMA-related kinase 2 -2.3331
NDC80 NDC80 kinetochore complex component -2.332
POLK polymerase (DNA directed) kappa -2.32931
EDC4 enhancer of mRNA decapping 4 -2.3218
HMGN2 high mobility group nucleosomal binding domain 2 -2.31929
RAD54L RAD54-like (S. cerevisiae) -2.31673
CETN2 centrin, EF-hand protein, 2 -2.29706
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -2.28383
MCM4 minichromosome maintenance complex component 4 -2.28276
MCMBP minichromosome maintenance complex binding protein -2.27906
THOP1 thimet oligopeptidase 1 -2.27562
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.27467
PALB2 partner and localizer of BRCA2 -2.27188
NCK1 NCK adaptor protein 1 -2.27057
ZWILCH zwilch kinetochore protein -2.26432
MTARC1 mitochondrial amidoxime reducing component 1 -2.25953
GDF7 growth differentiation factor 7 -2.25633
ZNF304 zinc finger protein 304 -2.25114
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.24105
RACGAP1 Rac GTPase activating protein 1 -2.24078
MRPL16 mitochondrial ribosomal protein L16 -2.23801
ZNF606 zinc finger protein 606 -2.23776
PIERCE1 piercer of microtubule wall 1 -2.22921
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.21911
AURKC aurora kinase C -2.21597
CCNE1 cyclin E1 -2.21424
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -2.21265
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.20958
ZNF274 zinc finger protein 274 -2.20268
SLC61A1 solute carrier family 61 member 1 -2.19681
MCM6 minichromosome maintenance complex component 6 -2.19275
CDC45 cell division cycle 45 -2.19102
DNAAF11 dynein axonemal assembly factor 11 -2.1841
SPAG5 sperm associated antigen 5 -2.18403
NME5 NME/NM23 family member 5 -2.17615
FBXO5 F-box protein 5 -2.16909
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -2.16851
MSH2 mutS homolog 2 -2.1684
CENPS-CORT CENPS-CORT readthrough -2.16259
COPS7A COP9 signalosome subunit 7A -2.15599
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.15211
DCLRE1A DNA cross-link repair 1A -2.14419
PCOLCE procollagen C-endopeptidase enhancer -2.14377
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.13692
HSDL2 hydroxysteroid dehydrogenase like 2 -2.13608
CTSV cathepsin V -2.13584
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.13405
SPA17 sperm autoantigenic protein 17 -2.128
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.12401
TRAP1 TNF receptor-associated protein 1 -2.12366
MRPL11 mitochondrial ribosomal protein L11 -2.12219
UNC119 unc-119 homolog (C. elegans) -2.12136
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.12052
CENPA centromere protein A -2.11985
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.11086
NLRP2B NLR family pyrin domain containing 2B -2.10715
INCENP inner centromere protein antigens 135/155kDa -2.10477
MKI67 marker of proliferation Ki-67 -2.09967
PRUNE1 prune exopolyphosphatase 1 -2.09891
ABT1 activator of basal transcription 1 -2.0963
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.09568
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.09477
TUBA1B tubulin, alpha 1b -2.09201
ERCC6L excision repair cross-complementation group 6-like -2.09068
TTC26 tetratricopeptide repeat domain 26 -2.08362
COQ3 coenzyme Q3 methyltransferase -2.07926
ZNF544 zinc finger protein 544 -2.07751
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.07562
GYG2 glycogenin 2 -2.0734
SNRPA small nuclear ribonucleoprotein polypeptide A -2.07246
HJURP Holliday junction recognition protein -2.07012
WRAP53 WD repeat containing, antisense to TP53 -2.06823
CENPM centromere protein M -2.06629
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.0649
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.06418
FZD7 frizzled class receptor 7 -2.06347
SEPHS1 selenophosphate synthetase 1 -2.06169
ZBED1 zinc finger, BED-type containing 1 -2.06056
TUBA3E tubulin, alpha 3e -2.05899
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.05616
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.05043
PGAP2 post-GPI attachment to proteins 2 -2.04727
PXMP2 peroxisomal membrane protein 2, 22kDa -2.04432
MCM5 minichromosome maintenance complex component 5 -2.04296
TMED9 transmembrane emp24 protein transport domain containing 9 -2.02767
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.02456
BLM Bloom syndrome, RecQ helicase-like -2.02195
PRMT1 protein arginine methyltransferase 1 -2.01965
THAP11 THAP domain containing 11 -2.01943
HMGA2 high mobility group AT-hook 2 -2.01826
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.01823
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.01803
ZNF83 zinc finger protein 83 -2.01656
COPS7B COP9 signalosome subunit 7B -2.01538
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.01257
ZNF329 zinc finger protein 329 -2.0121
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.00858