CRCGN012_HEPG2_24H:K02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN012_HEPG2_24H:K02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.56196
CBR3 carbonyl reductase 3 7.92724
LCN2 lipocalin 2 7.3117
MOK MOK protein kinase 6.08481
PEX11A peroxisomal biogenesis factor 11 alpha 5.62399
BACE2 beta-site APP-cleaving enzyme 2 5.6148
NOTCH1 notch 1 5.07103
INSIG1 insulin induced gene 1 4.52422
CXCL2 chemokine (C-X-C motif) ligand 2 4.24071
OXCT1 3-oxoacid CoA transferase 1 4.19992
CAPN1 calpain 1, (mu/I) large subunit 3.8668
KDM5A lysine (K)-specific demethylase 5A 3.70725
GRWD1 glutamate-rich WD repeat containing 1 3.51613
DENND2D DENN/MADD domain containing 2D 3.30951
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.29865
PARP1 poly (ADP-ribose) polymerase 1 3.22555
MYLK myosin light chain kinase 3.05504
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.01952
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.92176
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.91754
CHMP6 charged multivesicular body protein 6 2.83654
CARMIL1 capping protein regulator and myosin 1 linker 1 2.7632
EDN1 endothelin 1 2.70423
STX1A syntaxin 1A (brain) 2.66
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.64103
CSK c-src tyrosine kinase 2.6238
SATB1 SATB homeobox 1 2.62011
HOXA10 homeobox A10 2.61041
STXBP1 syntaxin binding protein 1 2.59419
TATDN2 TatD DNase domain containing 2 2.50578
E2F2 E2F transcription factor 2 2.47659
CHEK2 checkpoint kinase 2 2.47075
SHPK sedoheptulokinase 2.46595
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.45365
MAMLD1 mastermind-like domain containing 1 2.45179
PPARG peroxisome proliferator-activated receptor gamma 2.44634
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.38344
CBR1 carbonyl reductase 1 2.38086
GSTZ1 glutathione S-transferase zeta 1 2.33853
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.3285
CCDC85B coiled-coil domain containing 85B 2.29013
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.28506
HLA-DMA major histocompatibility complex, class II, DM alpha 2.26389
LOXL1 lysyl oxidase-like 1 2.25798
RIPK4 receptor-interacting serine-threonine kinase 4 2.21024
CXCR4 chemokine (C-X-C motif) receptor 4 2.1588
DIPK1A divergent protein kinase domain 1A 2.1502
DNTT DNA nucleotidylexotransferase 2.14526
HDGFL3 HDGF like 3 2.09822
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.09334
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.05739
HSPA8 heat shock 70kDa protein 8 2.05734
IL1RAP interleukin 1 receptor accessory protein 2.04289
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.03645

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.10074
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.59633
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.45965
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.12362
NGRN neugrin, neurite outgrowth associated -3.43462
SPAG4 sperm associated antigen 4 -3.25706
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.23517
TCTN1 tectonic family member 1 -3.13624
RPIA ribose 5-phosphate isomerase A -2.88214
FASTKD5 FAST kinase domains 5 -2.87586
RPS5 ribosomal protein S5 -2.79309
NVL nuclear VCP-like -2.7612
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.75624
DYNLT3 dynein, light chain, Tctex-type 3 -2.73193
CST7 cystatin F (leukocystatin) -2.73074
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) -2.66542
REEP5 receptor accessory protein 5 -2.61996
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.53044
ZDHHC6 zinc finger, DHHC-type containing 6 -2.44316
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.40978
CDC25B cell division cycle 25B -2.40658
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.381
WDR7 WD repeat domain 7 -2.36356
TCAP titin-cap -2.3484
NCK1 NCK adaptor protein 1 -2.33639
CCDC86 coiled-coil domain containing 86 -2.27001
IL32 interleukin 32 -2.26814
PPOX protoporphyrinogen oxidase -2.25734
PMCH pro-melanin-concentrating hormone -2.24309
RNF167 ring finger protein 167 -2.14771
TASOR transcription activation suppressor -2.13009
PMF1-BGLAP PMF1-BGLAP readthrough -2.12128
TMEM50A transmembrane protein 50A -2.11946
YME1L1 YME1-like 1 ATPase -2.09763
YIPF1 Yip1 domain family, member 1 -2.09446
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.08976
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.08927
ACOT9 acyl-CoA thioesterase 9 -2.07852
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.07189
ELANE elastase, neutrophil expressed -2.04688
TP53BP1 tumor protein p53 binding protein 1 -2.03956
SESN1 sestrin 1 -2.01094