CRCGN012_HEPG2_24H:K05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloroacetophenone 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN012_HEPG2_24H:K05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 7.97353
PNKP polynucleotide kinase 3'-phosphatase 6.28238
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.52986
AMDHD2 amidohydrolase domain containing 2 5.2661
ATP11B ATPase, class VI, type 11B 4.80955
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.75179
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.68114
PPARG peroxisome proliferator-activated receptor gamma 4.25154
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.20746
VAV3 vav 3 guanine nucleotide exchange factor 4.1307
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.9579
LCN2 lipocalin 2 3.7003
STIMATE STIM activating enhancer 3.67707
MOK MOK protein kinase 3.65635
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.40713
LOC122526780 uncharacterized LOC122526780 3.32317
CEP57 centrosomal protein 57kDa 3.3197
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.21668
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.99158
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.88587
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.85652
KAT5 K(lysine) acetyltransferase 5 2.7611
TIMP2 TIMP metallopeptidase inhibitor 2 2.67514
ANO1 anoctamin 1, calcium activated chloride channel 2.6348
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.5831
CHPF2 chondroitin polymerizing factor 2 2.48276
CCDC85B coiled-coil domain containing 85B 2.45919
TBXA2R thromboxane A2 receptor 2.41415
CYTH2 cytohesin 2 2.40939
DPH2 DPH2 homolog (S. cerevisiae) 2.35753
MCM3 minichromosome maintenance complex component 3 2.31736
JRKL JRK-like 2.28461
C1QA complement component 1, q subcomponent, A chain 2.25612
ADD3 adducin 3 (gamma) 2.24255
SYNE2 spectrin repeat containing, nuclear envelope 2 2.22279
GRWD1 glutamate-rich WD repeat containing 1 2.21909
CCNA1 cyclin A1 2.18799
ALDOC aldolase C, fructose-bisphosphate 2.18738
NXF3 nuclear RNA export factor 3 2.16593
CDK6 cyclin-dependent kinase 6 2.16437
WDR6 WD repeat domain 6 2.13509
BCL7B B-cell CLL/lymphoma 7B 2.1039
UBFD1 ubiquitin family domain containing 1 2.10058
IQGAP2 IQ motif containing GTPase activating protein 2 2.08609
PTOV1 prostate tumor overexpressed 1 2.07094
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.06076
CCL5 chemokine (C-C motif) ligand 5 2.05595

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.59554
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.11909
MRPS2 mitochondrial ribosomal protein S2 -6.26688
TRIB3 tribbles pseudokinase 3 -6.20761
LDHD lactate dehydrogenase D -5.97057
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.84979
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.62332
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.58354
DERA deoxyribose-phosphate aldolase (putative) -5.45149
TLCD3A TLC domain containing 3A -4.53145
FGFR4 fibroblast growth factor receptor 4 -4.41225
ZNF586 zinc finger protein 586 -3.82762
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.81472
CDC20 cell division cycle 20 -3.70103
KDM3A lysine (K)-specific demethylase 3A -3.65499
CRELD2 cysteine-rich with EGF-like domains 2 -3.57985
CGRRF1 cell growth regulator with ring finger domain 1 -3.42022
FAIM Fas apoptotic inhibitory molecule -3.22976
MTA1 metastasis associated 1 -3.17168
CERK ceramide kinase -3.12785
CDC25B cell division cycle 25B -3.06496
GDF15 growth differentiation factor 15 -2.93179
PECR peroxisomal trans-2-enoyl-CoA reductase -2.79917
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.68855
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.68157
ZMIZ1 zinc finger, MIZ-type containing 1 -2.63514
PCNA proliferating cell nuclear antigen -2.57014
TCTN1 tectonic family member 1 -2.54
ISOC1 isochorismatase domain containing 1 -2.53785
ANKRD10 ankyrin repeat domain 10 -2.49698
RPIA ribose 5-phosphate isomerase A -2.48741
CCNB2 cyclin B2 -2.4829
SCAND1 SCAN domain containing 1 -2.47818
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.47701
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.43949
EIF5 eukaryotic translation initiation factor 5 -2.4041
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.40149
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.38686
CDC45 cell division cycle 45 -2.35778
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.32001
USP6NL USP6 N-terminal like -2.28527
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.26901
RAI14 retinoic acid induced 14 -2.26783
FBXL12 F-box and leucine-rich repeat protein 12 -2.25373
IER3 immediate early response 3 -2.24518
WASHC4 WASH complex subunit 4 -2.24199
TIGAR TP53 induced glycolysis regulatory phosphatase -2.21749
TKT transketolase -2.19608
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.17445
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.15826
ZW10 zw10 kinetochore protein -2.14969
FASTKD5 FAST kinase domains 5 -2.14681
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -2.13627
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.12729
FBXL6 F-box and leucine-rich repeat protein 6 -2.11933
PTK2 protein tyrosine kinase 2 -2.11167
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.10792
TXNRD1 thioredoxin reductase 1 -2.10288
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) -2.08256
TRAF5 TNF receptor-associated factor 5 -2.0677
S100A14 S100 calcium binding protein A14 -2.06662
PRDM4 PR domain containing 4 -2.05316
BMAL1 basic helix-loop-helix ARNT like 1 -2.04903
BBS7 Bardet-Biedl syndrome 7 -2.02768
TFB2M transcription factor B2, mitochondrial -2.01769
GGCT gamma-glutamylcyclotransferase -2.00461
SLC75A1 solute carrier family 75 member 1 -2.00312