CRCGN012_HEPG2_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

632 genes differentially expressed following the CRCGN012_HEPG2_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FOXO4 forkhead box O4 10.0
DNM1 dynamin 1 9.64217
UBE2L6 ubiquitin-conjugating enzyme E2L 6 9.52878
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.40525
CBR1 carbonyl reductase 1 8.80408
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 7.94531
ALDOC aldolase C, fructose-bisphosphate 6.82135
MYC v-myc avian myelocytomatosis viral oncogene homolog 6.27096
H2BC12 H2B clustered histone 12 6.13894
TCEA2 transcription elongation factor A (SII), 2 5.98083
ABHD4 abhydrolase domain containing 4 5.85557
STX1A syntaxin 1A (brain) 5.72775
TIMP2 TIMP metallopeptidase inhibitor 2 5.67708
MVP major vault protein 5.65546
CDPF1 cysteine-rich, DPF motif domain containing 1 5.65248
CARMIL1 capping protein regulator and myosin 1 linker 1 5.46368
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.29494
DUSP6 dual specificity phosphatase 6 5.22964
CGRRF1 cell growth regulator with ring finger domain 1 5.22469
PLA2G15 phospholipase A2, group XV 5.04865
HMG20B high mobility group 20B 4.96273
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.92758
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.61828
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 4.31797
NUCB2 nucleobindin 2 4.31085
LGMN legumain 4.2958
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.21448
STXBP1 syntaxin binding protein 1 4.1056
CCDC71 coiled-coil domain containing 71 4.0866
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.0338
USP6NL USP6 N-terminal like 4.01392
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.95462
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.88906
IGFBP3 insulin-like growth factor binding protein 3 3.83527
GLRX glutaredoxin (thioltransferase) 3.82294
SKIC2 SKI2 subunit of superkiller complex 3.78055
KIF5C kinesin family member 5C 3.73426
IER3 immediate early response 3 3.71221
HTRA1 HtrA serine peptidase 1 3.69213
FABP2 fatty acid binding protein 2, intestinal 3.64911
ZNF646 zinc finger protein 646 3.64294
ABHD6 abhydrolase domain containing 6 3.63275
ARFIP2 ADP-ribosylation factor interacting protein 2 3.62554
AMDHD2 amidohydrolase domain containing 2 3.59352
NIT1 nitrilase 1 3.57862
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.55258
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.4679
ZMIZ1 zinc finger, MIZ-type containing 1 3.46227
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.44021
INTS3 integrator complex subunit 3 3.37642
PRKCD protein kinase C, delta 3.36377
KIAA0319 KIAA0319 3.36333
NMU neuromedin U 3.35385
BBC3 BCL2 binding component 3 3.31891
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.30037
CIAO3 cytosolic iron-sulfur assembly component 3 3.26343
TXNRD1 thioredoxin reductase 1 3.25237
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 3.24117
GRWD1 glutamate-rich WD repeat containing 1 3.22086
CLDN6 claudin 6 3.21528
FAT1 FAT atypical cadherin 1 3.20848
CYCS cytochrome c, somatic 3.20129
TLE6 transducin-like enhancer of split 6 3.19509
TM9SF2 transmembrane 9 superfamily member 2 3.16116
PECR peroxisomal trans-2-enoyl-CoA reductase 3.15503
NPR1 natriuretic peptide receptor 1 3.14102
CDA cytidine deaminase 3.13722
TMEM50A transmembrane protein 50A 3.13574
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.13443
CCND3 cyclin D3 3.11491
NEU2 sialidase 2 (cytosolic sialidase) 3.11222
E2F2 E2F transcription factor 2 3.11188
COG7 component of oligomeric golgi complex 7 3.10413
TRAPPC6A trafficking protein particle complex 6A 3.09146
CNPY4 canopy FGF signaling regulator 4 3.08805
HDAC7 histone deacetylase 7 3.07783
CELF3 CUGBP, Elav-like family member 3 3.06539
SPIN2A spindlin family, member 2A 3.04646
ICAM1 intercellular adhesion molecule 1 3.03895
GPR162 G protein-coupled receptor 162 3.03512
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.03031
ZNG1A Zn regulated GTPase metalloprotein activator 1A 3.02949
LRP10 low density lipoprotein receptor-related protein 10 3.02072
ELAVL3 ELAV like neuron-specific RNA binding protein 3 3.00433
ANO10 anoctamin 10 3.00381
DDB2 damage-specific DNA binding protein 2, 48kDa 2.98785
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.98062
FCHO1 FCH domain only 1 2.95419
VAT1 vesicle amine transport 1 2.93993
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.93752
ADGRD2 adhesion G protein-coupled receptor D2 2.93411
EFNA3 ephrin-A3 2.91888
BAMBI BMP and activin membrane-bound inhibitor 2.91231
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.90435
MAP7 microtubule-associated protein 7 2.89341
WDTC1 WD and tetratricopeptide repeats 1 2.88352
LSR lipolysis stimulated lipoprotein receptor 2.87655
ZDHHC6 zinc finger, DHHC-type containing 6 2.87202
SHARPIN SHANK-associated RH domain interactor 2.87123
GPR45 G protein-coupled receptor 45 2.86812
ARID4B AT rich interactive domain 4B (RBP1-like) 2.86563
PKDREJ polycystin (PKD) family receptor for egg jelly 2.84066
KCTD13 potassium channel tetramerization domain containing 13 2.82825
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.82205
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.82012
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.81048
TBPL1 TBP-like 1 2.81019
SEPHS2 selenophosphate synthetase 2 2.79853
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.78757
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 2.77733
VAMP8 vesicle-associated membrane protein 8 2.76394
ARMCX4 armadillo repeat containing, X-linked 4 2.76126
MAPK3 mitogen-activated protein kinase 3 2.75768
TXNL4B thioredoxin-like 4B 2.73238
ZBTB22 zinc finger and BTB domain containing 22 2.71996
DENND2D DENN/MADD domain containing 2D 2.69644
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.69501
PLCH2 phospholipase C, eta 2 2.69189
HESX1 HESX homeobox 1 2.68406
JADE3 jade family PHD finger 3 2.68363
PCDHA9 protocadherin alpha 9 2.65763
ACTL8 actin-like 8 2.64144
GRN granulin 2.64077
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.63508
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.63199
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.62863
CBR3 carbonyl reductase 3 2.62852
SETD1A SET domain containing 1A 2.61495
INPP1 inositol polyphosphate-1-phosphatase 2.61397
RUSC2 RUN and SH3 domain containing 2 2.6063
ACBD4 acyl-CoA binding domain containing 4 2.6046
ZNF821 zinc finger protein 821 2.58875
GSDMB gasdermin B 2.58544
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.57826
MXI1 MAX interactor 1, dimerization protein 2.57681
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.56483
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 2.55587
MACO1 macoilin 1 2.55521
TMCO1 transmembrane and coiled-coil domains 1 2.55345
SDK2 sidekick cell adhesion molecule 2 2.55103
TWF2 twinfilin actin binding protein 2 2.54647
PCDH1 protocadherin 1 2.54071
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.53643
RBM12B RNA binding motif protein 12B 2.5318
INTS5 integrator complex subunit 5 2.53155
NPDC1 neural proliferation, differentiation and control, 1 2.53
SPI1 Spi-1 proto-oncogene 2.53
MEST mesoderm specific transcript 2.52996
IQCC IQ motif containing C 2.52965
TM4SF20 transmembrane 4 L six family member 20 2.52944
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.52348
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.52259
DDR1 discoidin domain receptor tyrosine kinase 1 2.5181
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.51584
AARS1 alanyl-tRNA synthetase 1 2.51576
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.51409
SYTL2 synaptotagmin-like 2 2.51124
MMP2 matrix metallopeptidase 2 2.50906
UBXN1 UBX domain protein 1 2.50176
C5AR2 complement component 5a receptor 2 2.49745
MYF5 myogenic factor 5 2.49349
TTC33 tetratricopeptide repeat domain 33 2.49191
CST4 cystatin S 2.48641
ZCCHC14 zinc finger, CCHC domain containing 14 2.48259
ADRA2C adrenoceptor alpha 2C 2.47835
AKAP4 A kinase (PRKA) anchor protein 4 2.46546
SOCS2 suppressor of cytokine signaling 2 2.4651
RRAS related RAS viral (r-ras) oncogene homolog 2.46083
ASXL3 additional sex combs like transcriptional regulator 3 2.4559
MTNR1B melatonin receptor 1B 2.45373
TUFM Tu translation elongation factor, mitochondrial 2.45154
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.44843
LPAR2 lysophosphatidic acid receptor 2 2.44129
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.43705
NPC1 Niemann-Pick disease, type C1 2.43646
HNF4G hepatocyte nuclear factor 4, gamma 2.43332
SPTBN4 spectrin, beta, non-erythrocytic 4 2.43155
RAB30 RAB30, member RAS oncogene family 2.43135
TFEC transcription factor EC 2.43065
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.42244
TRAFD1 TRAF-type zinc finger domain containing 1 2.41629
DIPK1A divergent protein kinase domain 1A 2.40743
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.40016
SCRN3 secernin 3 2.39309
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.38856
HOXA10 homeobox A10 2.38706
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 2.38046
PPARD peroxisome proliferator-activated receptor delta 2.37976
IFNW1 interferon, omega 1 2.37548
MAGEB2 melanoma antigen family B2 2.36292
TBXA2R thromboxane A2 receptor 2.36239
SCARB1 scavenger receptor class B, member 1 2.36181
CALCOCO1 calcium binding and coiled-coil domain 1 2.36122
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.36057
TTLL3 tubulin tyrosine ligase-like family member 3 2.35935
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.34742
SATB1 SATB homeobox 1 2.34714
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.34684
PTAFR platelet-activating factor receptor 2.3453
STYK1 serine/threonine/tyrosine kinase 1 2.34448
INSM1 insulinoma-associated 1 2.34408
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.33843
SCPEP1 serine carboxypeptidase 1 2.33233
PLXND1 plexin D1 2.32987
BRME1 break repair meiotic recombinase recruitment factor 1 2.32813
EXOSC4 exosome component 4 2.32747
TRIB1 tribbles pseudokinase 1 2.32557
NCOA3 nuclear receptor coactivator 3 2.32507
CCL14 chemokine (C-C motif) ligand 14 2.32128
RAB3A RAB3A, member RAS oncogene family 2.31974
BZW2 basic leucine zipper and W2 domains 2 2.318
DKKL1 dickkopf-like 1 2.3176
CCP110 centriolar coiled coil protein 110kDa 2.31431
MRNIP MRN complex interacting protein 2.31357
GSTP1 glutathione S-transferase pi 1 2.3125
GOLGB1 golgin B1 2.30927
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.30658
RASAL2 RAS protein activator like 2 2.30583
UNC13A unc-13 homolog A (C. elegans) 2.30486
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.30263
ZFP36 ZFP36 ring finger protein 2.30262
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.29359
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.29333
SLC67A1 solute carrier family 67 member 1 2.2884
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.28826
THSD7A thrombospondin, type I, domain containing 7A 2.28506
FAM110D family with sequence similarity 110, member D 2.2816
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.28094
FFAR3 free fatty acid receptor 3 2.27294
CCDC92 coiled-coil domain containing 92 2.27279
FGD6 FYVE, RhoGEF and PH domain containing 6 2.27018
GNS glucosamine (N-acetyl)-6-sulfatase 2.26981
TSHZ2 teashirt zinc finger homeobox 2 2.26558
ITGA1 integrin, alpha 1 2.26051
GDAP2 ganglioside induced differentiation associated protein 2 2.25654
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.25573
TCF15 transcription factor 15 (basic helix-loop-helix) 2.24955
CHN1 chimerin 1 2.24903
CST1 cystatin SN 2.24854
CCDC186 coiled-coil domain containing 186 2.24631
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.24597
FKBP6 FK506 binding protein 6, 36kDa 2.23908
ZBP1 Z-DNA binding protein 1 2.23663
GM2A GM2 ganglioside activator 2.2343
PRDX1 peroxiredoxin 1 2.23155
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 2.22885
RTN2 reticulon 2 2.22624
JUP junction plakoglobin 2.22579
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.22236
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.21815
OSGIN2 oxidative stress induced growth inhibitor family member 2 2.21533
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.21107
BACE2 beta-site APP-cleaving enzyme 2 2.20701
FASLG Fas ligand (TNF superfamily, member 6) 2.20364
SH2D3A SH2 domain containing 3A 2.20038
ZIC4 Zic family member 4 2.19523
CYTH1 cytohesin 1 2.19307
DMTF1 cyclin D binding myb-like transcription factor 1 2.18842
CYB561 cytochrome b561 2.18788
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.18747
CATSPER2 cation channel, sperm associated 2 2.18713
NPHP1 nephronophthisis 1 (juvenile) 2.18572
UNC93B1 unc-93 homolog B1 (C. elegans) 2.1853
RPL8 ribosomal protein L8 2.18454
AKR1C3 aldo-keto reductase family 1, member C3 2.18451
NHLH1 nescient helix loop helix 1 2.18329
ELOB elongin B 2.18195
DPF1 D4, zinc and double PHD fingers family 1 2.181
ACE angiotensin I converting enzyme 2.18042
PCDHGB5 protocadherin gamma subfamily B, 5 2.17753
MILR1 mast cell immunoglobulin-like receptor 1 2.17605
ANKRD40CL ANKRD40 C-terminal like 2.17585
ZNF280B zinc finger protein 280B 2.17548
STXBP2 syntaxin binding protein 2 2.17544
DUX4 double homeobox 4 2.17417
H2BC21 H2B clustered histone 21 2.17374
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.17327
HMX1 H6 family homeobox 1 2.17034
RBKS ribokinase 2.1701
TBX6 T-box 6 2.1697
HLA-DMA major histocompatibility complex, class II, DM alpha 2.16949
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.16699
H1-2 H1.2 linker histone, cluster member 2.16485
CRABP2 cellular retinoic acid binding protein 2 2.16453
TPPP tubulin polymerization promoting protein 2.16356
ATG12 autophagy related 12 2.16266
ZNF580 zinc finger protein 580 2.16259
TMEM121 transmembrane protein 121 2.15836
CLCN1 chloride channel, voltage-sensitive 1 2.15266
MYL10 myosin, light chain 10, regulatory 2.14938
ARHGAP33 Rho GTPase activating protein 33 2.13914
MOK MOK protein kinase 2.13772
ATG10 autophagy related 10 2.13423
KIAA1614 KIAA1614 2.13393
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.13255
PRCP prolylcarboxypeptidase (angiotensinase C) 2.13186
WDR44 WD repeat domain 44 2.13177
MUC13 mucin 13, cell surface associated 2.13138
MMRN2 multimerin 2 2.13106
DYNC2I1 dynein 2 intermediate chain 1 2.13037
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.12885
EPN2 epsin 2 2.12638
PRKCQ protein kinase C, theta 2.12438
TM4SF5 transmembrane 4 L six family member 5 2.12368
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.12347
DPY19L4 dpy-19-like 4 (C. elegans) 2.12072
HAND1 heart and neural crest derivatives expressed 1 2.11574
FKBP8 FK506 binding protein 8, 38kDa 2.11415
EMCN endomucin 2.11334
MUC3B mucin 3B, cell surface associated 2.11217
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.10923
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.10679
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.10483
SYCP1 synaptonemal complex protein 1 2.10299
IFT70A intraflagellar transport 70A 2.0985
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.09679
JPH2 junctophilin 2 2.09629
DDN dendrin 2.09588
MATK megakaryocyte-associated tyrosine kinase 2.09514
GPR153 G protein-coupled receptor 153 2.09468
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.09423
IQSEC2 IQ motif and Sec7 domain 2 2.09187
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 2.0898
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.08692
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 2.08475
FRMD4B FERM domain containing 4B 2.0836
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.08354
AGFG2 ArfGAP with FG repeats 2 2.08293
TYW2 tRNA wybutosine-synthesizing protein 2 2.08067
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.08045
PRR15L proline rich 15-like 2.0801
ZNF34 zinc finger protein 34 2.07822
TCN2 transcobalamin II 2.0776
TMPRSS3 transmembrane protease, serine 3 2.07751
KHDC1L KH homology domain containing 1-like 2.07426
ZNF79 zinc finger protein 79 2.07238
DOK4 docking protein 4 2.07213
MGST3 microsomal glutathione S-transferase 3 2.06808
TRHDE thyrotropin-releasing hormone degrading enzyme 2.0669
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.06555
PRSS8 protease, serine, 8 2.06524
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.05995
ARSF arylsulfatase F 2.05859
ZNF154 zinc finger protein 154 2.05542
TLX1 T-cell leukemia homeobox 1 2.05483
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.05435
TRIM49D2 tripartite motif containing 49D2 2.05369
DACH1 dachshund family transcription factor 1 2.05243
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.05155
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.05149
TAS2R1 taste receptor, type 2, member 1 2.05119
MARK4 MAP/microtubule affinity-regulating kinase 4 2.05109
TAC4 tachykinin 4 (hemokinin) 2.04943
OR7E24 olfactory receptor, family 7, subfamily E, member 24 2.04926
LDHC lactate dehydrogenase C 2.04839
H2AC19 H2A clustered histone 19 2.04802
FBXO2 F-box protein 2 2.04617
H2BC3 H2B clustered histone 3 2.04499
NXPH4 neurexophilin 4 2.04313
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.04258
FAM114A2 family with sequence similarity 114, member A2 2.03736
YPEL5 yippee-like 5 (Drosophila) 2.03698
SCIN scinderin 2.03695
RND1 Rho family GTPase 1 2.03691
UBA1 ubiquitin-like modifier activating enzyme 1 2.0347
TMC5 transmembrane channel-like 5 2.03306
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.03007
PHAF1 phagosome assembly factor 1 2.02989
KIAA0408 KIAA0408 2.02837
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.02568
OSGIN1 oxidative stress induced growth inhibitor 1 2.02502
CD22 CD22 molecule 2.02298
SSTR2 somatostatin receptor 2 2.02056
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.02005
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.01937
H2BC17 H2B clustered histone 17 2.01936
AFAP1 actin filament associated protein 1 2.01831
TJP3 tight junction protein 3 2.0168
ADAM30 ADAM metallopeptidase domain 30 2.01613
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.01572
EID1 EP300 interacting inhibitor of differentiation 1 2.01478
ZNF550 zinc finger protein 550 2.01447
TBX4 T-box 4 2.01383
CA6 carbonic anhydrase VI 2.01362
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.0136
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.01255
ROM1 retinal outer segment membrane protein 1 2.01189
ASCL3 achaete-scute family bHLH transcription factor 3 2.00977
PHF1 PHD finger protein 1 2.00964
PAOX polyamine oxidase (exo-N4-amino) 2.0081
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.00639
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.00596
LOC102723713 TP53-target gene 3 protein 2.00157
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.00144
EFCAB14 EF-hand calcium binding domain 14 2.00108
DPPA4 developmental pluripotency associated 4 2.00087
TRIM62 tripartite motif containing 62 2.00057

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.5971
TCTN1 tectonic family member 1 -8.0073
FAIM Fas apoptotic inhibitory molecule -7.99767
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -7.88997
CRELD2 cysteine-rich with EGF-like domains 2 -7.22986
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.90762
FOSL1 FOS-like antigen 1 -6.87634
LOC124907782 dual specificity protein phosphatase 22 -6.79418
CD320 CD320 molecule -6.65339
LDHD lactate dehydrogenase D -6.31694
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -6.30015
RPIA ribose 5-phosphate isomerase A -6.29243
TATDN2 TatD DNase domain containing 2 -6.14626
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -6.12841
ISOC1 isochorismatase domain containing 1 -6.11557
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.07294
GTPBP8 GTP-binding protein 8 (putative) -6.0531
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -6.02396
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.72751
KEAP1 kelch-like ECH-associated protein 1 -5.71471
PLK1 polo-like kinase 1 -5.6785
PGM1 phosphoglucomutase 1 -5.66996
STAP2 signal transducing adaptor family member 2 -5.4978
MRPS2 mitochondrial ribosomal protein S2 -5.34028
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.27243
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -5.26959
RRAGA Ras-related GTP binding A -5.18196
CDK1 cyclin-dependent kinase 1 -5.06943
CCNA2 cyclin A2 -5.05564
TCERG1 transcription elongation regulator 1 -4.99515
SPAG7 sperm associated antigen 7 -4.92666
MELK maternal embryonic leucine zipper kinase -4.90779
NNT nicotinamide nucleotide transhydrogenase -4.83336
GLOD4 glyoxalase domain containing 4 -4.75071
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.7472
SOAT2 sterol O-acyltransferase 2 -4.73527
TLCD3A TLC domain containing 3A -4.72898
CCNB2 cyclin B2 -4.70706
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.65975
LRRC41 leucine rich repeat containing 41 -4.45885
CCDC86 coiled-coil domain containing 86 -4.40836
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.40425
NUP85 nucleoporin 85kDa -4.38082
PCCB propionyl CoA carboxylase, beta polypeptide -4.37358
TMEM109 transmembrane protein 109 -4.16043
CDC25B cell division cycle 25B -4.07396
MSRA methionine sulfoxide reductase A -4.0688
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.06207
UBE2C ubiquitin-conjugating enzyme E2C -4.0585
ECH1 enoyl CoA hydratase 1, peroxisomal -3.94705
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.82306
RPN1 ribophorin I -3.76185
CDC25A cell division cycle 25A -3.7479
SLC35F2 solute carrier family 35, member F2 -3.70715
CDK4 cyclin-dependent kinase 4 -3.50331
MRPS16 mitochondrial ribosomal protein S16 -3.46037
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.44286
SLC35B1 solute carrier family 35, member B1 -3.41471
AURKA aurora kinase A -3.41221
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.30929
BCL7B B-cell CLL/lymphoma 7B -3.29085
SMC4 structural maintenance of chromosomes 4 -3.28293
NFIL3 nuclear factor, interleukin 3 regulated -3.27453
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.25355
KIF15 kinesin family member 15 -3.2426
FBXO7 F-box protein 7 -3.1591
PSAT1 phosphoserine aminotransferase 1 -3.15635
RCC1L RCC1 like -3.14998
MRPL19 mitochondrial ribosomal protein L19 -3.14233
CTSL cathepsin L -3.08601
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.08062
KLHL21 kelch-like family member 21 -3.07756
CCNB1 cyclin B1 -3.06015
USP1 ubiquitin specific peptidase 1 -3.04813
PHF2 PHD finger protein 2 -3.04338
TMEM97 transmembrane protein 97 -3.03068
FOXM1 forkhead box M1 -2.99541
EXOSC8 exosome component 8 -2.98982
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.94686
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.93171
MPDU1 mannose-P-dolichol utilization defect 1 -2.89562
HAT1 histone acetyltransferase 1 -2.88932
TTK TTK protein kinase -2.8697
STAT1 signal transducer and activator of transcription 1, 91kDa -2.86349
CDT1 chromatin licensing and DNA replication factor 1 -2.86074
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.84512
WASHC4 WASH complex subunit 4 -2.83503
ZBTB35 zinc finger and BTB domain containing 35 -2.81266
KIF11 kinesin family member 11 -2.80213
MYLK myosin light chain kinase -2.79549
RFC2 replication factor C (activator 1) 2, 40kDa -2.78438
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.78124
RBM14-RBM4 RBM14-RBM4 readthrough -2.75948
NCAPH non-SMC condensin I complex, subunit H -2.75621
TUBB6 tubulin, beta 6 class V -2.7511
HRAS Harvey rat sarcoma viral oncogene homolog -2.7464
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.72747
PHF11 PHD finger protein 11 -2.72385
PUF60 poly-U binding splicing factor 60KDa -2.71563
DERA deoxyribose-phosphate aldolase (putative) -2.71238
NUP62 nucleoporin 62kDa -2.67938
BIRC5 baculoviral IAP repeat containing 5 -2.67029
ATF5 activating transcription factor 5 -2.66867
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.6345
CHEK1 checkpoint kinase 1 -2.62771
CRYZ crystallin, zeta (quinone reductase) -2.62366
MAPK13 mitogen-activated protein kinase 13 -2.61605
GTPBP6 GTP binding protein 6 (putative) -2.61152
PARP1 poly (ADP-ribose) polymerase 1 -2.60417
KRCC1 lysine-rich coiled-coil 1 -2.60346
ACOT2 acyl-CoA thioesterase 2 -2.58238
C2CD2 C2 calcium-dependent domain containing 2 -2.57745
ELAC2 elaC ribonuclease Z 2 -2.57683
HADH hydroxyacyl-CoA dehydrogenase -2.56624
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.55652
DBF4 DBF4 zinc finger -2.55462
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.55021
MRM3 mitochondrial rRNA methyltransferase 3 -2.54499
CASC3 cancer susceptibility candidate 3 -2.54416
DEPDC1 DEP domain containing 1 -2.54309
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.53978
GYS1 glycogen synthase 1 (muscle) -2.52748
SOX4 SRY (sex determining region Y)-box 4 -2.51957
ETFB electron-transfer-flavoprotein, beta polypeptide -2.51216
DENND4B DENN/MADD domain containing 4B -2.51112
YME1L1 YME1-like 1 ATPase -2.50956
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.50314
FANCG Fanconi anemia, complementation group G -2.49923
STAMBP STAM binding protein -2.49339
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.47534
HEBP1 heme binding protein 1 -2.46905
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.46062
EMC6 ER membrane protein complex subunit 6 -2.45733
NUBP2 nucleotide binding protein 2 -2.45316
IDE insulin-degrading enzyme -2.44959
TYK2 tyrosine kinase 2 -2.44642
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.44488
SPAG4 sperm associated antigen 4 -2.44207
TFDP1 transcription factor Dp-1 -2.42992
TPM1 tropomyosin 1 (alpha) -2.42373
SUMF2 sulfatase modifying factor 2 -2.4218
RFC3 replication factor C (activator 1) 3, 38kDa -2.41853
TEAD4 TEA domain family member 4 -2.41822
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.41151
TNIP1 TNFAIP3 interacting protein 1 -2.40885
CPNE3 copine III -2.40276
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.3953
ITGB5 integrin, beta 5 -2.39516
HJURP Holliday junction recognition protein -2.39079
VAV3 vav 3 guanine nucleotide exchange factor -2.38994
SQOR sulfide quinone oxidoreductase -2.37351
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.35913
ENDOG endonuclease G -2.35894
GALE UDP-galactose-4-epimerase -2.35778
ZC3H14 zinc finger CCCH-type containing 14 -2.35418
CAPN15 calpain 15 -2.35112
PFAS phosphoribosylformylglycinamidine synthase -2.34829
CCDC59 coiled-coil domain containing 59 -2.34669
POLK polymerase (DNA directed) kappa -2.33423
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.33122
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.32666
EIF5 eukaryotic translation initiation factor 5 -2.32641
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.32556
BLCAP bladder cancer associated protein -2.32385
DCTD dCMP deaminase -2.31798
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.30219
RBM15B RNA binding motif protein 15B -2.3011
MLH1 mutL homolog 1 -2.29897
TERT telomerase reverse transcriptase -2.28755
RANGRF RAN guanine nucleotide release factor -2.28563
AVEN apoptosis, caspase activation inhibitor -2.28414
NSD2 nuclear receptor binding SET domain protein 2 -2.28029
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.25956
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.25516
GTSE1 G-2 and S-phase expressed 1 -2.25345
UGDH UDP-glucose 6-dehydrogenase -2.24117
CENPA centromere protein A -2.22668
PTS 6-pyruvoyltetrahydropterin synthase -2.22547
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.22386
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.22347
NUP88 nucleoporin 88kDa -2.21802
RIOX2 ribosomal oxygenase 2 -2.21433
PLPBP pyridoxal phosphate binding protein -2.21225
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.21181
VRK1 vaccinia related kinase 1 -2.2118
ICE2 interactor of little elongation complex ELL subunit 2 -2.21036
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.21013
TMEM33 transmembrane protein 33 -2.20663
TMED5 transmembrane emp24 protein transport domain containing 5 -2.20088
ANXA7 annexin A7 -2.20029
MYD88 myeloid differentiation primary response 88 -2.19638
PEG3 paternally expressed 3 -2.19508
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -2.18999
RTCA RNA 3'-terminal phosphate cyclase -2.18931
PARP2 poly (ADP-ribose) polymerase 2 -2.18192
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.17777
PARPBP PARP1 binding protein -2.17732
CLUH clustered mitochondria (cluA/CLU1) homolog -2.16803
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.16083
FICD FIC domain containing -2.15641
VCP valosin containing protein -2.15302
AURKB aurora kinase B -2.15196
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.14892
DNM1L dynamin 1-like -2.14848
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.14217
FANCC Fanconi anemia, complementation group C -2.14215
KIF18B kinesin family member 18B -2.14044
CDCA8 cell division cycle associated 8 -2.13928
SCCPDH saccharopine dehydrogenase (putative) -2.12622
MLYCD malonyl-CoA decarboxylase -2.12612
TRIB3 tribbles pseudokinase 3 -2.12482
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.12468
RWDD2B RWD domain containing 2B -2.12115
WTAP Wilms tumor 1 associated protein -2.11634
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.10418
MRPS7 mitochondrial ribosomal protein S7 -2.10315
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.09191
IFRD2 interferon-related developmental regulator 2 -2.08508
FBXO5 F-box protein 5 -2.08424
RPH3AL rabphilin 3A-like (without C2 domains) -2.07697
VBP1 von Hippel-Lindau binding protein 1 -2.07278
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.06962
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.06184
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.06061
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.05653
TMEM260 transmembrane protein 260 -2.0556
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.04945
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.04557
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.04315
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -2.04084
SKA1 spindle and kinetochore associated complex subunit 1 -2.03814
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.03608
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.01492
SDF2L1 stromal cell-derived factor 2-like 1 -2.01393
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.01195