CRCGN012_HEPG2_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

264 genes differentially expressed following the CRCGN012_HEPG2_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBE2L6 ubiquitin-conjugating enzyme E2L 6 8.99352
CBR1 carbonyl reductase 1 8.21989
DNM1 dynamin 1 7.78014
FOXO4 forkhead box O4 7.68276
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 7.27732
STIMATE STIM activating enhancer 6.84184
CIAO3 cytosolic iron-sulfur assembly component 3 6.59969
CSK c-src tyrosine kinase 6.35488
CDPF1 cysteine-rich, DPF motif domain containing 1 6.19024
ALDOC aldolase C, fructose-bisphosphate 5.97195
MVP major vault protein 5.38769
TIMP2 TIMP metallopeptidase inhibitor 2 5.36687
ABHD6 abhydrolase domain containing 6 5.33037
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.91646
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 4.88767
AMDHD2 amidohydrolase domain containing 2 4.80901
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.7674
H2BC12 H2B clustered histone 12 4.57845
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.51976
ADGRE5 adhesion G protein-coupled receptor E5 4.35022
CHN1 chimerin 1 4.17894
NPDC1 neural proliferation, differentiation and control, 1 4.05325
HMG20B high mobility group 20B 3.90049
NOTCH1 notch 1 3.87002
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.78336
PLA2G15 phospholipase A2, group XV 3.7289
CCP110 centriolar coiled coil protein 110kDa 3.72354
FAT1 FAT atypical cadherin 1 3.65942
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.65259
NUCB2 nucleobindin 2 3.58605
CHMP6 charged multivesicular body protein 6 3.57286
ABHD4 abhydrolase domain containing 4 3.56442
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.55
TUBB6 tubulin, beta 6 class V 3.54599
VGLL4 vestigial-like family member 4 3.42422
DUSP6 dual specificity phosphatase 6 3.34596
NOSIP nitric oxide synthase interacting protein 3.33924
NCOA3 nuclear receptor coactivator 3 3.20542
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.17662
FCHO1 FCH domain only 1 3.1416
ANO10 anoctamin 10 3.11474
TCEA2 transcription elongation factor A (SII), 2 2.98265
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.88258
SKIC2 SKI2 subunit of superkiller complex 2.85819
STXBP1 syntaxin binding protein 1 2.84094
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.83673
ARFIP2 ADP-ribosylation factor interacting protein 2 2.81062
UBQLN2 ubiquilin 2 2.8052
ADGRG1 adhesion G protein-coupled receptor G1 2.76108
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.74166
DENND2D DENN/MADD domain containing 2D 2.68927
TMEM50A transmembrane protein 50A 2.68624
TXNRD1 thioredoxin reductase 1 2.68032
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.65866
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.62391
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.58517
TBPL1 TBP-like 1 2.55126
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.52346
IER3 immediate early response 3 2.51932
ANO1 anoctamin 1, calcium activated chloride channel 2.51532
NMU neuromedin U 2.478
TWF2 twinfilin actin binding protein 2 2.46571
VAT1 vesicle amine transport 1 2.44533
HSPB1 heat shock 27kDa protein 1 2.44492
AARS1 alanyl-tRNA synthetase 1 2.44461
TRAPPC6A trafficking protein particle complex 6A 2.40424
CDR2L cerebellar degeneration-related protein 2-like 2.39608
EFNA3 ephrin-A3 2.39454
IQCC IQ motif containing C 2.39198
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.35993
INTS3 integrator complex subunit 3 2.35272
MMP2 matrix metallopeptidase 2 2.35226
PRCP prolylcarboxypeptidase (angiotensinase C) 2.34935
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.34869
STX1A syntaxin 1A (brain) 2.34727
DOK7 docking protein 7 2.32299
EHD4 EH-domain containing 4 2.32225
FXYD7 FXYD domain containing ion transport regulator 7 2.31057
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.30647
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.28998
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.27797
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.27154
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.23005
PLS1 plastin 1 2.22972
ADRA2C adrenoceptor alpha 2C 2.22926
PECR peroxisomal trans-2-enoyl-CoA reductase 2.22904
OSGIN1 oxidative stress induced growth inhibitor 1 2.22351
SPRED2 sprouty-related, EVH1 domain containing 2 2.21871
EGR1 early growth response 1 2.21748
MOK MOK protein kinase 2.21253
CCND3 cyclin D3 2.20073
BBC3 BCL2 binding component 3 2.20026
TM9SF2 transmembrane 9 superfamily member 2 2.19055
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.18344
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.17967
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.17302
SYP synaptophysin 2.16992
TARBP1 TAR (HIV-1) RNA binding protein 1 2.16581
LOC122526780 uncharacterized LOC122526780 2.16511
SNAP29 synaptosomal-associated protein, 29kDa 2.15611
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.15112
FPGS folylpolyglutamate synthase 2.13355
BMP4 bone morphogenetic protein 4 2.13322
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.13122
CNPY4 canopy FGF signaling regulator 4 2.12767
BORCS6 BLOC-1 related complex subunit 6 2.12751
EMX2 empty spiracles homeobox 2 2.12432
MORN1 MORN repeat containing 1 2.11917
TUFM Tu translation elongation factor, mitochondrial 2.08013
RIPK4 receptor-interacting serine-threonine kinase 4 2.07608
NIT1 nitrilase 1 2.06956
HDAC7 histone deacetylase 7 2.05909
ZNF205 zinc finger protein 205 2.05898
FKBPL FK506 binding protein like 2.05605
GPR162 G protein-coupled receptor 162 2.04967
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.04001
BAMBI BMP and activin membrane-bound inhibitor 2.02739
MAST3 microtubule associated serine/threonine kinase 3 2.02498
CCDC71 coiled-coil domain containing 71 2.02338
DOHH deoxyhypusine hydroxylase/monooxygenase 2.02171
IFT57 intraflagellar transport 57 2.0186
RUSC2 RUN and SH3 domain containing 2 2.01027
RSU1 Ras suppressor protein 1 2.0087
NKRF NFKB repressing factor 2.00021

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.74047
ADI1 acireductone dioxygenase 1 -6.57679
ISOC1 isochorismatase domain containing 1 -6.20765
TCERG1 transcription elongation regulator 1 -6.197
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -6.19583
TCTN1 tectonic family member 1 -5.83497
TATDN2 TatD DNase domain containing 2 -5.34734
CDK1 cyclin-dependent kinase 1 -5.19629
ZMIZ1 zinc finger, MIZ-type containing 1 -5.17925
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.16895
NGRN neugrin, neurite outgrowth associated -5.02331
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -5.02215
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.9344
CCNA2 cyclin A2 -4.8581
ATF5 activating transcription factor 5 -4.77019
CCNB2 cyclin B2 -4.75222
LOC124907782 dual specificity protein phosphatase 22 -4.62811
NUP85 nucleoporin 85kDa -4.55393
GLOD4 glyoxalase domain containing 4 -4.50593
FAIM Fas apoptotic inhibitory molecule -4.48329
PGM1 phosphoglucomutase 1 -4.45162
LRRC41 leucine rich repeat containing 41 -4.28494
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -4.26247
RPIA ribose 5-phosphate isomerase A -4.24234
KDM3A lysine (K)-specific demethylase 3A -4.04073
TLCD3A TLC domain containing 3A -4.00404
KEAP1 kelch-like ECH-associated protein 1 -3.8889
SOAT2 sterol O-acyltransferase 2 -3.79791
ZNF586 zinc finger protein 586 -3.72829
RRAGA Ras-related GTP binding A -3.58496
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.54593
CPNE3 copine III -3.53567
PLK1 polo-like kinase 1 -3.4769
PCNA proliferating cell nuclear antigen -3.47233
ECH1 enoyl CoA hydratase 1, peroxisomal -3.42602
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.31416
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.31004
ICAM3 intercellular adhesion molecule 3 -3.30989
BCL7B B-cell CLL/lymphoma 7B -3.2837
PARP1 poly (ADP-ribose) polymerase 1 -3.25898
LDHD lactate dehydrogenase D -3.25828
HADH hydroxyacyl-CoA dehydrogenase -3.23531
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.23395
NNT nicotinamide nucleotide transhydrogenase -3.22172
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.20992
GTPBP8 GTP-binding protein 8 (putative) -3.15837
TM9SF3 transmembrane 9 superfamily member 3 -3.13487
TOR1A torsin family 1, member A (torsin A) -3.1338
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.10876
NFIL3 nuclear factor, interleukin 3 regulated -3.10705
PCCB propionyl CoA carboxylase, beta polypeptide -3.05883
CDC25A cell division cycle 25A -3.03679
PUF60 poly-U binding splicing factor 60KDa -3.00097
CDC25B cell division cycle 25B -2.97476
USP1 ubiquitin specific peptidase 1 -2.95116
CHEK1 checkpoint kinase 1 -2.94733
SPAG4 sperm associated antigen 4 -2.88715
MAPK13 mitogen-activated protein kinase 13 -2.80249
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.79965
ZBTB35 zinc finger and BTB domain containing 35 -2.77656
MRPS30 mitochondrial ribosomal protein S30 -2.75782
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.75204
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.73454
CDK7 cyclin-dependent kinase 7 -2.73003
RGS2 regulator of G-protein signaling 2 -2.72551
DERA deoxyribose-phosphate aldolase (putative) -2.71822
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.71311
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.7119
CASC3 cancer susceptibility candidate 3 -2.68328
STAMBP STAM binding protein -2.68282
LAGE3 L antigen family, member 3 -2.6648
PHF2 PHD finger protein 2 -2.62892
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.60297
ZW10 zw10 kinetochore protein -2.58579
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.5172
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.5093
CRYZ crystallin, zeta (quinone reductase) -2.48595
RCC1L RCC1 like -2.47123
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.46196
RBM15B RNA binding motif protein 15B -2.44301
ANXA7 annexin A7 -2.43445
ZC3H14 zinc finger CCCH-type containing 14 -2.43328
AURKA aurora kinase A -2.4194
BARD1 BRCA1 associated RING domain 1 -2.40753
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.39974
NUP62 nucleoporin 62kDa -2.38968
FXN frataxin -2.36988
CEP55 centrosomal protein 55kDa -2.36015
KIF15 kinesin family member 15 -2.35408
SPAG7 sperm associated antigen 7 -2.35121
SLC35B1 solute carrier family 35, member B1 -2.34823
IDE insulin-degrading enzyme -2.34793
FOXM1 forkhead box M1 -2.34054
TMEM97 transmembrane protein 97 -2.33143
EAPP E2F-associated phosphoprotein -2.32819
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.31202
FOSL1 FOS-like antigen 1 -2.30856
TIMELESS timeless circadian clock -2.30174
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.27847
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.26004
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.24302
CDK4 cyclin-dependent kinase 4 -2.24276
MRPS16 mitochondrial ribosomal protein S16 -2.24241
ELAC2 elaC ribonuclease Z 2 -2.23449
UBE2C ubiquitin-conjugating enzyme E2C -2.23116
ACOT2 acyl-CoA thioesterase 2 -2.22544
EXO1 exonuclease 1 -2.22436
KIF11 kinesin family member 11 -2.20274
PSRC1 proline/serine-rich coiled-coil 1 -2.17941
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.17344
PYGM phosphorylase, glycogen, muscle -2.16397
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.162
ZNF426 zinc finger protein 426 -2.15204
DNM1L dynamin 1-like -2.15117
NIPSNAP2 nipsnap homolog 2 -2.14205
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.13948
CELF2 CUGBP, Elav-like family member 2 -2.13572
TPM1 tropomyosin 1 (alpha) -2.11964
PTHLH parathyroid hormone-like hormone -2.11869
BIRC5 baculoviral IAP repeat containing 5 -2.11464
ZNF134 zinc finger protein 134 -2.10697
CAB39 calcium binding protein 39 -2.09415
KDM5D lysine (K)-specific demethylase 5D -2.09189
RPH3AL rabphilin 3A-like (without C2 domains) -2.09132
FBXO7 F-box protein 7 -2.08694
KRCC1 lysine-rich coiled-coil 1 -2.08555
ATMIN ATM interactor -2.07102
HJURP Holliday junction recognition protein -2.07096
PBX3 pre-B-cell leukemia homeobox 3 -2.06977
PDPN podoplanin -2.05439
THBS4 thrombospondin 4 -2.04132
SPATA20 spermatogenesis associated 20 -2.0388
ZNF211 zinc finger protein 211 -2.03217
LYRM1 LYR motif containing 1 -2.01232
CDCA8 cell division cycle associated 8 -2.01022
VAV3 vav 3 guanine nucleotide exchange factor -2.00806
TTK TTK protein kinase -2.00529
SMC4 structural maintenance of chromosomes 4 -2.00477
PARPBP PARP1 binding protein -2.00333
EVI2B ecotropic viral integration site 2B -2.00253