CRCGN012_HEPG2_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description a-1,2,3,4,5,6-hexachlorocyclohexane 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
RPL39L ribosomal protein L39-like 6.74242
CSK c-src tyrosine kinase 6.32543
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.28729
CHMP6 charged multivesicular body protein 6 4.78677
E2F2 E2F transcription factor 2 4.5117
LCN2 lipocalin 2 4.38496
FCHO1 FCH domain only 1 4.24869
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.11723
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.08275
CXCR4 chemokine (C-X-C motif) receptor 4 3.92906
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.85819
ADRB2 adrenoceptor beta 2, surface 3.83547
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.8078
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.55777
MSRA methionine sulfoxide reductase A 3.51201
EPHB2 EPH receptor B2 3.50579
PLSCR1 phospholipid scramblase 1 3.48792
RPP38 ribonuclease P/MRP 38kDa subunit 3.4618
NOTCH1 notch 1 3.35794
CBR3 carbonyl reductase 3 3.15898
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.10351
CYCS cytochrome c, somatic 2.96456
HSPA1A heat shock 70kDa protein 1A 2.79872
STK10 serine/threonine kinase 10 2.70683
MOK MOK protein kinase 2.68397
EPHA3 EPH receptor A3 2.38741
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.33984
CHN1 chimerin 1 2.1897
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.17487
PCNA proliferating cell nuclear antigen 2.12275
DAGLA diacylglycerol lipase, alpha 2.10712
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.09798
NMU neuromedin U 2.04328
EHD4 EH-domain containing 4 2.01132
TMEM40 transmembrane protein 40 2.00632
KLK8 kallikrein-related peptidase 8 2.00445

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.77381
NGRN neugrin, neurite outgrowth associated -6.52325
CDC25B cell division cycle 25B -5.0841
ZNF586 zinc finger protein 586 -4.33657
CCNB2 cyclin B2 -4.30005
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.23583
ERBB2 erb-b2 receptor tyrosine kinase 2 -4.21471
CCDC86 coiled-coil domain containing 86 -3.84686
OXA1L oxidase (cytochrome c) assembly 1-like -3.46165
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.36823
GNAS GNAS complex locus -3.29302
PRPF19 pre-mRNA processing factor 19 -2.70856
CD99 CD99 molecule -2.303
NOP53 NOP53 ribosome biogenesis factor -2.2828
TESK2 testis-specific kinase 2 -2.26893
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 -2.22535
SESN1 sestrin 1 -2.16717
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.02236
SPAG4 sperm associated antigen 4 -2.01589
RPS5 ribosomal protein S5 -2.0055
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -2.00272