| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | a-1,2,3,4,5,6-hexachlorocyclohexane 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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83 genes differentially expressed following the CRCGN012_HEPG2_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 8.76188 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 6.36503 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.32025 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.26894 |
| MSRA | methionine sulfoxide reductase A | 4.11226 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.02353 |
| ADRB2 | adrenoceptor beta 2, surface | 3.92547 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.78597 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 3.77401 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.76701 |
| CHMP6 | charged multivesicular body protein 6 | 3.76181 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.68989 |
| UBQLN2 | ubiquilin 2 | 3.64563 |
| SQOR | sulfide quinone oxidoreductase | 3.4714 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.46324 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.41251 |
| E2F2 | E2F transcription factor 2 | 3.41059 |
| CYCS | cytochrome c, somatic | 3.36183 |
| TAC4 | tachykinin 4 (hemokinin) | 3.32081 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.21648 |
| NOTCH1 | notch 1 | 3.12695 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.90799 |
| PLSCR1 | phospholipid scramblase 1 | 2.83119 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.74209 |
| EPHB2 | EPH receptor B2 | 2.6323 |
| PLSCR3 | phospholipid scramblase 3 | 2.53925 |
| PRKCH | protein kinase C, eta | 2.39899 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.38403 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.34662 |
| AKTIP | AKT interacting protein | 2.31023 |
| PRKCQ | protein kinase C, theta | 2.31007 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2.3016 |
| ANAPC15 | anaphase promoting complex subunit 15 | 2.26113 |
| LOC122526780 | uncharacterized LOC122526780 | 2.24332 |
| HOOK2 | hook microtubule-tethering protein 2 | 2.23454 |
| ISG15 | ISG15 ubiquitin-like modifier | 2.22204 |
| CEP57 | centrosomal protein 57kDa | 2.21691 |
| MLF1 | myeloid leukemia factor 1 | 2.20127 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.19974 |
| MX1 | MX dynamin-like GTPase 1 | 2.1979 |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 2.1838 |
| SMIM40 | small integral membrane protein 40 | 2.15938 |
| STK10 | serine/threonine kinase 10 | 2.14036 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 2.03463 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -6.68085 |
| LDHD | lactate dehydrogenase D | -6.50211 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -5.87633 |
| PEG10 | paternally expressed 10 | -4.905 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.83678 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.77637 |
| BLCAP | bladder cancer associated protein | -3.69113 |
| MEST | mesoderm specific transcript | -3.62842 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.58712 |
| TMEM109 | transmembrane protein 109 | -3.57601 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.56908 |
| AURKB | aurora kinase B | -3.44697 |
| CDC25B | cell division cycle 25B | -3.34022 |
| GDF15 | growth differentiation factor 15 | -3.30359 |
| ADI1 | acireductone dioxygenase 1 | -3.08959 |
| CCNB2 | cyclin B2 | -3.0502 |
| CHMP4B | charged multivesicular body protein 4B | -2.98594 |
| TP53BP2 | tumor protein p53 binding protein 2 | -2.90573 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.84275 |
| STMN1 | stathmin 1 | -2.81478 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.80289 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.76304 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.61625 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.61026 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.43605 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.35945 |
| CDC20 | cell division cycle 20 | -2.3471 |
| CCNB1 | cyclin B1 | -2.32455 |
| HMG20B | high mobility group 20B | -2.24642 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.21125 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -2.19579 |
| ZNF586 | zinc finger protein 586 | -2.17539 |
| PLK1 | polo-like kinase 1 | -2.11816 |
| BBS10 | Bardet-Biedl syndrome 10 | -2.09542 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.05973 |
| TXNRD1 | thioredoxin reductase 1 | -2.04133 |
| BICC1 | BicC family RNA binding protein 1 | -2.02688 |
| LYPLA1 | lysophospholipase I | -2.02367 |
| RAP2A | RAP2A, member of RAS oncogene family | -2.00945 |
