CRCGN012_HEPG2_24H:K18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description a-1,2,3,4,5,6-hexachlorocyclohexane 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN012_HEPG2_24H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 5.17813
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.21382
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.95485
GSTZ1 glutathione S-transferase zeta 1 3.89482
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.83974
CARMIL1 capping protein regulator and myosin 1 linker 1 3.7822
GPER1 G protein-coupled estrogen receptor 1 3.28808
NOSIP nitric oxide synthase interacting protein 2.82743
KIF14 kinesin family member 14 2.55541
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.45006
CYB561 cytochrome b561 2.20985
GPATCH8 G patch domain containing 8 2.16595
LSR lipolysis stimulated lipoprotein receptor 2.14875
CCNH cyclin H 2.0669

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.53891
GDF15 growth differentiation factor 15 -5.30339
CCDC86 coiled-coil domain containing 86 -4.21512
OXA1L oxidase (cytochrome c) assembly 1-like -4.20669
EGF epidermal growth factor -4.13294
PLK1 polo-like kinase 1 -3.91154
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.8623
PCNA proliferating cell nuclear antigen -2.88633
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.87336
MVP major vault protein -2.75061
TM9SF3 transmembrane 9 superfamily member 3 -2.53418
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.42384
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.202
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.05237