CRCGN012_HEPG2_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,8-dimethyl-3h-imidazo[4,5-f]quinoxalin-2-ylamine 2.46 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN012_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 3.92333
ADRB2 adrenoceptor beta 2, surface 3.82753
E2F2 E2F transcription factor 2 3.70394
ADGRE5 adhesion G protein-coupled receptor E5 3.67373
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.65784
VGLL4 vestigial-like family member 4 3.64624
LYN LYN proto-oncogene, Src family tyrosine kinase 3.54253
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.30322
HOXA10 homeobox A10 3.20624
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.14843
GPER1 G protein-coupled estrogen receptor 1 3.12494
MYLK myosin light chain kinase 3.09959
RPL39L ribosomal protein L39-like 3.09407
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.06685
CHMP6 charged multivesicular body protein 6 2.94518
CIAO3 cytosolic iron-sulfur assembly component 3 2.78166
UBQLN2 ubiquilin 2 2.74138
PRR15L proline rich 15-like 2.73091
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.65553
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.52262
PLSCR1 phospholipid scramblase 1 2.51263
PRKCH protein kinase C, eta 2.39773
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.39675
TFB2M transcription factor B2, mitochondrial 2.34034
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.28674
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.2864
HAPLN1 hyaluronan and proteoglycan link protein 1 2.17853
LOC122526780 uncharacterized LOC122526780 2.09401
CNPY3 canopy FGF signaling regulator 3 2.07905
DEK DEK proto-oncogene 2.01157

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
TRIB3 tribbles pseudokinase 3 -6.79813
DNM1L dynamin 1-like -5.70712
MAP7 microtubule-associated protein 7 -4.0837
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.57637
OXA1L oxidase (cytochrome c) assembly 1-like -3.23169
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.21356
FHL2 four and a half LIM domains 2 -3.13711
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.10473
CCDC86 coiled-coil domain containing 86 -3.05613
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.04001
EGF epidermal growth factor -2.97541
FGFR4 fibroblast growth factor receptor 4 -2.96834
MAPK13 mitogen-activated protein kinase 13 -2.8796
CCNB2 cyclin B2 -2.71272
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.41076
PRPF4 pre-mRNA processing factor 4 -2.33945
NVL nuclear VCP-like -2.32867
REEP5 receptor accessory protein 5 -2.11623
MED23 mediator complex subunit 23 -2.02803
DERA deoxyribose-phosphate aldolase (putative) -2.00005