| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3,8-dimethyl-3h-imidazo[4,5-f]quinoxalin-2-ylamine 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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54 genes differentially expressed following the CRCGN012_HEPG2_24H:K23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSK | c-src tyrosine kinase | 7.70139 |
| CHMP6 | charged multivesicular body protein 6 | 7.42105 |
| MYLK | myosin light chain kinase | 5.30158 |
| ADRB2 | adrenoceptor beta 2, surface | 5.06994 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 4.8217 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.81755 |
| E2F2 | E2F transcription factor 2 | 4.78429 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 4.50779 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.44447 |
| GPATCH8 | G patch domain containing 8 | 4.36408 |
| LOC122526780 | uncharacterized LOC122526780 | 4.25271 |
| NOSIP | nitric oxide synthase interacting protein | 3.71872 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 3.24545 |
| FZD7 | frizzled class receptor 7 | 3.19683 |
| CRTAP | cartilage associated protein | 3.12639 |
| JADE2 | jade family PHD finger 2 | 3.09068 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.80012 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.78448 |
| CYBC1 | cytochrome b-245 chaperone 1 | 2.6972 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.67612 |
| CHN1 | chimerin 1 | 2.59405 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.58414 |
| CBR3 | carbonyl reductase 3 | 2.55379 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.52213 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.42507 |
| PLSCR3 | phospholipid scramblase 3 | 2.35809 |
| HOOK2 | hook microtubule-tethering protein 2 | 2.35701 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.35356 |
| NMU | neuromedin U | 2.19524 |
| WASF3 | WAS protein family, member 3 | 2.16216 |
| ZNF589 | zinc finger protein 589 | 2.11773 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAPK13 | mitogen-activated protein kinase 13 | -5.53502 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.19449 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -5.10895 |
| DSG2 | desmoglein 2 | -5.10854 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.62832 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.07576 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.45303 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.25184 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.1687 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.02088 |
| PRPF4 | pre-mRNA processing factor 4 | -2.94611 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.88853 |
| PCNA | proliferating cell nuclear antigen | -2.86805 |
| DNM1L | dynamin 1-like | -2.84714 |
| SLC35F2 | solute carrier family 35, member F2 | -2.66399 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.4332 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.38486 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.3233 |
| ADI1 | acireductone dioxygenase 1 | -2.15751 |
| PRRC2B | proline-rich coiled-coil 2B | -2.12668 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -2.06442 |
| TMEM41B | transmembrane protein 41B | -2.05939 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.02417 |
