CRCGN012_HEPG2_24H:L01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

71 genes differentially expressed following the CRCGN012_HEPG2_24H:L01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.98202
UBQLN2 ubiquilin 2 5.9253
CSK c-src tyrosine kinase 5.71767
AMDHD2 amidohydrolase domain containing 2 4.16815
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.83892
CIAO3 cytosolic iron-sulfur assembly component 3 3.51145
HEBP1 heme binding protein 1 3.49158
MCOLN1 mucolipin 1 3.48811
SNAP25 synaptosomal-associated protein, 25kDa 3.30197
RPL39L ribosomal protein L39-like 3.23343
STIMATE STIM activating enhancer 3.12638
E2F2 E2F transcription factor 2 3.10343
ADRB2 adrenoceptor beta 2, surface 3.05774
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.88587
STK10 serine/threonine kinase 10 2.8842
CDK6 cyclin-dependent kinase 6 2.76171
CHN1 chimerin 1 2.70384
BLMH bleomycin hydrolase 2.57437
FOXJ3 forkhead box J3 2.56828
HOXA10 homeobox A10 2.26859
MEST mesoderm specific transcript 2.23954
FAM110B family with sequence similarity 110, member B 2.14402
ZDHHC6 zinc finger, DHHC-type containing 6 2.11783
STK26 serine/threonine protein kinase 26 2.06386
DIPK1A divergent protein kinase domain 1A 2.05699
CTSF cathepsin F 2.0551
NLGN4Y neuroligin 4, Y-linked 2.01156

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ZNF586 zinc finger protein 586 -7.40978
CCNB2 cyclin B2 -5.23564
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.20275
GTPBP8 GTP-binding protein 8 (putative) -3.89952
COG7 component of oligomeric golgi complex 7 -3.86737
MRPS2 mitochondrial ribosomal protein S2 -3.76752
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.59064
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.54353
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.54175
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.51379
GDF15 growth differentiation factor 15 -3.51379
DDIT4 DNA-damage-inducible transcript 4 -3.48803
SLC35F2 solute carrier family 35, member F2 -3.35529
PEG10 paternally expressed 10 -3.1674
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.07423
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.0189
ZMIZ1 zinc finger, MIZ-type containing 1 -3.00073
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.97505
OXA1L oxidase (cytochrome c) assembly 1-like -2.85387
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.85148
PLK1 polo-like kinase 1 -2.76532
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.75983
ALDOC aldolase C, fructose-bisphosphate -2.71795
KDM3A lysine (K)-specific demethylase 3A -2.71259
PRPF4 pre-mRNA processing factor 4 -2.62496
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.61542
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.42072
ZIM3 zinc finger, imprinted 3 -2.41943
ZNF134 zinc finger protein 134 -2.40847
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.28079
TUBB6 tubulin, beta 6 class V -2.23145
VPS35L VPS35 endosomal protein sorting factor like -2.20757
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.195
COQ9 coenzyme Q9 -2.18462
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.17524
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.17147
ZNF764 zinc finger protein 764 -2.15059
NIPSNAP2 nipsnap homolog 2 -2.10129
ZNF652 zinc finger protein 652 -2.09499
ZNF551 zinc finger protein 551 -2.05926
RAI14 retinoic acid induced 14 -2.05622
NOTCH2NLB notch 2 N-terminal like B -2.01376
ZNF211 zinc finger protein 211 -2.01238