CRCGN012_HEPG2_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN012_HEPG2_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 4.65841
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.18406
EPHA3 EPH receptor A3 4.02609
LCN2 lipocalin 2 3.76744
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.57604
E2F2 E2F transcription factor 2 3.54726
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.544
MOK MOK protein kinase 3.34993
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.29266
CXCL2 chemokine (C-X-C motif) ligand 2 2.94702
ADRB2 adrenoceptor beta 2, surface 2.82954
ATP11B ATPase, class VI, type 11B 2.72139
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.65337
FZD7 frizzled class receptor 7 2.60918
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.55971
CIAO3 cytosolic iron-sulfur assembly component 3 2.52664
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.47661
NOSIP nitric oxide synthase interacting protein 2.34132
SNAP25 synaptosomal-associated protein, 25kDa 2.31345
GPER1 G protein-coupled estrogen receptor 1 2.24665
ANO1 anoctamin 1, calcium activated chloride channel 2.22463
PIH1D1 PIH1 domain containing 1 2.18051
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.13526
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.11048
ELOVL6 ELOVL fatty acid elongase 6 2.1045
TBP TATA box binding protein 2.07937
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.07909
ZDHHC6 zinc finger, DHHC-type containing 6 2.05792
PLSCR1 phospholipid scramblase 1 2.02639
VGLL4 vestigial-like family member 4 2.02582
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.02271
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.01711

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -7.36659
ITFG1 integrin alpha FG-GAP repeat containing 1 -7.14465
PCNA proliferating cell nuclear antigen -5.65027
CCNB1 cyclin B1 -5.56004
ZMIZ1 zinc finger, MIZ-type containing 1 -5.21065
EGF epidermal growth factor -3.87696
VAT1 vesicle amine transport 1 -3.85
ADI1 acireductone dioxygenase 1 -3.5756
FBXL12 F-box and leucine-rich repeat protein 12 -3.53938
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.47717
CHMP4B charged multivesicular body protein 4B -3.41099
LOC124907782 dual specificity protein phosphatase 22 -3.13267
NGRN neugrin, neurite outgrowth associated -3.13082
MAP7 microtubule-associated protein 7 -3.03413
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.96794
CLTB clathrin, light chain B -2.85922
TUBB6 tubulin, beta 6 class V -2.63801
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.55036
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.3028
SLC35F2 solute carrier family 35, member F2 -2.24633
TES testin LIM domain protein -2.16352
CCDC86 coiled-coil domain containing 86 -2.14908
SNX11 sorting nexin 11 -2.09955
DDIT4 DNA-damage-inducible transcript 4 -2.05761
FOS FBJ murine osteosarcoma viral oncogene homolog -2.04424