CRCGN012_HEPG2_24H:L04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN012_HEPG2_24H:L04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.20676
GPATCH8 G patch domain containing 8 5.14976
CCDC85B coiled-coil domain containing 85B 4.99154
CYCS cytochrome c, somatic 4.90227
CIAO3 cytosolic iron-sulfur assembly component 3 4.85819
STIMATE STIM activating enhancer 4.80118
INTS3 integrator complex subunit 3 4.51232
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.42002
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.33288
NFIL3 nuclear factor, interleukin 3 regulated 4.00906
EPHB2 EPH receptor B2 3.72954
GPER1 G protein-coupled estrogen receptor 1 3.49146
RPP38 ribonuclease P/MRP 38kDa subunit 3.47819
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.38977
PPARG peroxisome proliferator-activated receptor gamma 3.17443
KLHL9 kelch-like family member 9 3.12786
CHN1 chimerin 1 3.04226
DIPK1A divergent protein kinase domain 1A 3.03593
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.02619
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.7742
MAP7 microtubule-associated protein 7 2.62109
LRRC61 leucine rich repeat containing 61 2.58978
JADE2 jade family PHD finger 2 2.5536
CCL2 chemokine (C-C motif) ligand 2 2.52722
NPDC1 neural proliferation, differentiation and control, 1 2.38144
COQ3 coenzyme Q3 methyltransferase 2.30413
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.30222
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.26491
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.22762
MYBBP1A MYB binding protein (P160) 1a 2.20818
KLHDC2 kelch domain containing 2 2.19322
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 2.13528
CLCA1 chloride channel accessory 1 2.12676
BORA bora, aurora kinase A activator 2.11236
DSCC1 DNA replication and sister chromatid cohesion 1 2.09927
FASTK Fas-activated serine/threonine kinase 2.07195
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.02755
CES3 carboxylesterase 3 2.01798
ABRAXAS2 abraxas 2, BRISC complex subunit 2.00419

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.0586
TES testin LIM domain protein -5.62039
VAT1 vesicle amine transport 1 -5.12466
LDHD lactate dehydrogenase D -4.78356
KDM3A lysine (K)-specific demethylase 3A -4.47747
PCNA proliferating cell nuclear antigen -4.45834
FGFR4 fibroblast growth factor receptor 4 -4.42903
CAB39 calcium binding protein 39 -4.38529
ANKRD10 ankyrin repeat domain 10 -3.92803
CCNB2 cyclin B2 -3.6911
HAT1 histone acetyltransferase 1 -3.5197
RFC2 replication factor C (activator 1) 2, 40kDa -3.41705
GNAS GNAS complex locus -3.06
CD58 CD58 molecule -3.03445
ICAM3 intercellular adhesion molecule 3 -2.89007
TLCD3A TLC domain containing 3A -2.7459
USP6NL USP6 N-terminal like -2.56365
CXCL2 chemokine (C-X-C motif) ligand 2 -2.54227
TEX30 testis expressed 30 -2.40681
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.37789
CD320 CD320 molecule -2.33413
HMG20B high mobility group 20B -2.30522
TRAPPC8 trafficking protein particle complex 8 -2.25245
GORASP1 golgi reassembly stacking protein 1, 65kDa -2.22502
SSBP2 single-stranded DNA binding protein 2 -2.19419
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.18942
WASHC4 WASH complex subunit 4 -2.16801
CLTB clathrin, light chain B -2.12585
HLA-DMA major histocompatibility complex, class II, DM alpha -2.11784
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.04979
VPREB1 pre-B lymphocyte 1 -2.03545
SACS sacsin molecular chaperone -2.00947